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Qaagi - Book of Why

Causes

Effects

decreased clearance , or a combination of both(passive) may be causedlactate elevation

other conditions such as a variety of medications , hepatic insufficiency , or hyperlactatemia due to primarily cardiac causes of hypoperfusion(passive) may be influenced byLactate elevations

Many problemscauseelevated lactate

other metabolic factorscould causeelevated lactate

Most of the toxins under SIG acidoseswill also causeelevated lactate

i.e. other mechanisms related to metabolic derangementscan causelactate elevation

the muscle death which in turn throws myoglobin cells which destroys the kidneys(passive) is caused byLactate elevation

Despite the fact that lactate is nonspecific for anaerobic metabolismcan causelactate elevation

motor activationcan causelactate elevation

venous stasismay causelactate elevation

from many other causes including recent exercise , and generalized shockcan resultfrom many other causes including recent exercise , and generalized shock

to the elevated anion gap and the osmolar gapmay contributeto the elevated anion gap and the osmolar gap

two distinct compartmentscausestwo distinct compartments

a false elevation of EtOH levelsMay causea false elevation of EtOH levels

from global hypoperfusion or from cellular metabolic alterations that may or may not represent tissue hypoxia ( 5may resultfrom global hypoperfusion or from cellular metabolic alterations that may or may not represent tissue hypoxia ( 5

from glycolysis and excess carnitineresultingfrom glycolysis and excess carnitine

the detrimental neurological effect of hypoglycemia ... also substantially diminished catecholamines , growth hormone , cortisol , and symptomatic responses to hypoglycemia.[14 ] Experimental data on rat hippocampi with ischemia - reperfusion injurycan preventthe detrimental neurological effect of hypoglycemia ... also substantially diminished catecholamines , growth hormone , cortisol , and symptomatic responses to hypoglycemia.[14 ] Experimental data on rat hippocampi with ischemia - reperfusion injury

from circulatory insufficiency ( tissue hypoxiaresultingfrom circulatory insufficiency ( tissue hypoxia

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