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Qaagi - Book of Why

Causes

Effects

anaerobic metabolismcausingelevated lactate levels

conditionscan causeelevated lactate levels

conditionscausinglactate growth

instead(passive) are ... causedElevated lactate levels

hepatic gluconeogenesiscausingelevated lactate levels

A number of conditionscan causeelevated lactate levels

number of conditionscan causeelevated lactate levels

what number of conditionscan causeelevated lactate levels

C. A number of conditionscan causeelevated lactate levels

online number of conditionscan causeelevated lactate levels

S. A number of conditionscan causeelevated lactate levels

by EARS2 mutations(passive) caused byhigh lactate ' LTBL

surgery and the factorscausehigh lactate

by novel mutations in the EARS2 gene(passive) caused byhigh lactate

the bloodcausingelevated serum lactate

many disorders and diseasescausehigh lactate

Thiamin deficiencycauseshigh lactate

gut dysbiosis(passive) is caused byhigh lactate

hypoxemia ( e.g. hypoperfusion(passive) is causedhigh lactate

by a day(passive) caused bylactate levels

by anaerobic metabolism(passive) caused bylactate accumulation

hyperglycemiacausedlactate levels

aerobic metabolismcausinglactate accumulation

conditionscausinglactate accumulation

when lactate production exceeds lactate clearance during exercise or increasing intensity(passive) is causedLactate threshold

Metformincauseslactate accumulation

Mesenteric ischemia ... the distal coloncould ... have contributedto the observed lactate elevation

hypoxic mitochondrial dysfunctioncauseslactate accumulation

7 Factorsmay influenceLactate Threshold

6 Factorsmay influenceLactate Threshold

the mechanismsinfluencelactate threshold

Any process that causes tissue hypoperfusion and subsequent anaerobic metabolismcan leadto an elevated lactate

Diet ... another factormay influencelactate threshold

reduced oxygenleadingto elevated lactate

lots of conditionscauseelevated lactate

What drugscan causean elevated lactate

Mitochondrial functionmay ... be causinglactate elevation

the acidic shiftis causedby elevated lactate

both methanol and ethylene glycolmay causean elevated lactate

delirium and end organ perfusion deficitcausingthe elevated lactate

from decreased clearance by the livercan also resultfrom decreased clearance by the liver

to increased vigilance amongst cliniciansmay have leadto increased vigilance amongst clinicians

fatiguecausesfatigue

muscle cramping fatigue and brain fogcan causemuscle cramping fatigue and brain fog

on survivaladversely influencedon survival

a search for the underlying causeshould prompta search for the underlying cause

from a combination of excess formation and decreased utilization of lactateresultsfrom a combination of excess formation and decreased utilization of lactate

to physical fatigueleadsto physical fatigue

additional neuronal dysfunctioncan causeadditional neuronal dysfunction

muscular fatiguedoes ... causemuscular fatigue

in pyruvate accumulation in cancer cellsalso resultsin pyruvate accumulation in cancer cells

muscular paincausesmuscular pain

from a combination of excess formationresultsfrom a combination of excess formation

during exercisecausesduring exercise

to the dreaded muscle burnwould ... leadto the dreaded muscle burn

The illness(passive) is caused byThe illness

to acidification of the mediacan leadto acidification of the media

depletion of bicarbonate , elevated anion gap , and metabolic acidosis in a processcausesdepletion of bicarbonate , elevated anion gap , and metabolic acidosis in a process

microenvironmental acidificationcausesmicroenvironmental acidification

depletion of bicarbonate , elevated anion gap , and metabolic acidosiscausesdepletion of bicarbonate , elevated anion gap , and metabolic acidosis

to panic attacks and anxietycould leadto panic attacks and anxiety

acidification of culture medium and lead to high osmolality and low viabilitycan causeacidification of culture medium and lead to high osmolality and low viability

depletion of bicarbonate , elevated anion gapcausesdepletion of bicarbonate , elevated anion gap

depletion of bicarbonatecausesdepletion of bicarbonate

in an improvement in VTresultingin an improvement in VT

to the anion gapwill also contributeto the anion gap

to the elevated anion gap and the osmolar gapmay contributeto the elevated anion gap and the osmolar gap

to superiorleadsto superior

to loss of menstrual periods in woman and low testosterone levels in mencan leadto loss of menstrual periods in woman and low testosterone levels in men

from glycolysisresultsfrom glycolysis

to gynecomastiacan leadto gynecomastia

to the NAD(P)H biphasic responsecontributesto the NAD(P)H biphasic response

to higher cellular lactate levelsleadingto higher cellular lactate levels

fatigue ... and there is NO lactate thresholddoes ... causefatigue ... and there is NO lactate threshold

to an elevated lactate / pyruvate ratioleadingto an elevated lactate / pyruvate ratio

from many other causes including recent exercise , and generalized shockcan resultfrom many other causes including recent exercise , and generalized shock

the hydrogen ions in the muscle to increasecausesthe hydrogen ions in the muscle to increase

to rapid fatigue if the lactate is not removedleadsto rapid fatigue if the lactate is not removed

to rapid fatigue if the lactate is not removed it should beleadsto rapid fatigue if the lactate is not removed it should be

to lactic acidosis ( serum pHmay leadto lactic acidosis ( serum pH

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