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Qaagi - Book of Why

Causes

Effects

raised anaerobic metabolism under ischemic conditions(passive) caused bylactate accumulation

impaired pyruvate metabolismleadingto lactate accumulation

Every bout of sprinting and attackingmay resultin lactate accumulation

a reduction in oxygen - independent ATP re - synthesisresultsin lactate accumulation

an important mechanismto preventlactate build - up

Some athletes take themto preventlactate build - up

03/01/2007 - " Continuous washout of newborn heartspreventedlactate accumulation

In addition , glycolysis was uncoupled from glucose oxidationresultingin accumulation of lactate

Mutations of subunits of the PDC system that impair the activity of the enzyme complex ... likelyto leadto lactate accumulation

healthy adult of excess glucosecausesan accumulation of lactate

Lactate — Salicylates uncouple oxidative phosphorylation , which results in abnormal cellular energy production and utilization ; the cell becomes dependent upon anaerobic metabolismresultingin accumulation of lactate

although compensating for energy deficitprovokedexcessive lactate accumulation

Metformin ... patients with renal or hepatic impairment , cardiovascular disease or hypoxic conditionscauselactate accumulation

Cyanide poisoning produces rapid blockade of cellular respiration due to binding to cytochromeaa3resultingin accumulation of lactate

Although it is believed to have prognostic significance in heart failure ( HF ) , data on the pathomechanismsleadto lactate accumulation

Under anaerobic conditions , glycolysis continues to function unabated ,resultingin lactate accumulation

metabolism ( energy production without oxygenresultsin lactate accumulation

In traumatic brain injury conditions , aerobic metabolism is diminished due to reductions in cellular oxygen , or due to mitochondrial dysfunctioncausingincreased lactate accumulation

When that fuel ignites to produce energy , the by products created ( carbon dioxide , lactate , etc ) need to be cleared as quickly , and as efficiently , as possibleto preventlactate build up

Consumption of alcoholmay causebuildup of lactate

Drinking alcoholmay causebuildup of lactate

This efficient use of lactic acidpreventslactate build - up

A Study has shown MCTscan preventlactate build - up

acidsleadingto lactate accumulation

Limit carbohydrate administration to 3 - 4 mg / kg / minto preventlactate buildup

heart issuescan ... causelactate buildup

During labor , myometrial smooth muscle cells generate ATP mainly via anaerobic glycolysisresultingin accumulation of lactate

Lactate Clearance ... an intensitycauseslactate buildup

to increaseto preventlactate accumulation

lactobacilli replace S. bovisresultsin excessive lactate accumulation

orderto preventlactate build up

lactate utilisation was strongly inhibitedresultingin lactate accumulation

to ensurecauselactate build - up

This , in turn , demonstrates the overall demanding nature of the game and the frequent use of glucose metabolism during a soccer matchuntimely resultingin lactate accumulation

while climbing also helpsto preventlactate building up

A high extracellular lactate concentration in the TME could prevent its export from glycolytic DCleadingto lactate accumulation

hypoxic mitochondrial dysfunctioncauseslactate accumulation

that the production of lactic acid often exceeds clearanceresultingin lactate accumulation

fatigue ... heavy compound lifts ,causeslactate build - up

MCTs have been knownto preventlactate buildup

muscle fatigue and paincausesmuscle fatigue and pain

acidosis which then will cause fatiguewill causeacidosis which then will cause fatigue

in lactate acidosisresultingin lactate acidosis

an increased concentration of hydrogen ions and corresponding acidosis , a primary factor in muscle fatiguecausesan increased concentration of hydrogen ions and corresponding acidosis , a primary factor in muscle fatigue

brain tissue acidosis(passive) caused bybrain tissue acidosis

symptoms of lactic acidosis during exercisecausessymptoms of lactic acidosis during exercise

fatigue more quicklycausesfatigue more quickly

lactic acidosis ( Metabolic acidosiscauseslactic acidosis ( Metabolic acidosis

lactic acidosis ( usually mildcan causelactic acidosis ( usually mild

A condition of low blood pH ( metabolic acidosis(passive) is caused byA condition of low blood pH ( metabolic acidosis

to tissue acidosis inhibiting both vascular autoregulation and phosphofructokinaseleadingto tissue acidosis inhibiting both vascular autoregulation and phosphofructokinase

oxygen debt ... acidosis →lactate reconverted to pyruvate in livercan createoxygen debt ... acidosis →lactate reconverted to pyruvate in liver

to intracellular acidosis ... by virtue of the fact that it is a strong acid anion that fundamentally alters the behavior of watercontributesto intracellular acidosis ... by virtue of the fact that it is a strong acid anion that fundamentally alters the behavior of water

fatigue during said intense activity ... hindering our performancecausesfatigue during said intense activity ... hindering our performance

tissue acidosis ... damaging the tissue and disrupting normal metabolism even when oxygen is returnedcreatestissue acidosis ... damaging the tissue and disrupting normal metabolism even when oxygen is returned

weakness and muscle pain(passive) caused byweakness and muscle pain

to a blockade of the glycolytic pathwayleadsto a blockade of the glycolytic pathway

to fatigue as it is associated with fatigue development and respiratory rates ( Marconnet , 1992promptsto fatigue as it is associated with fatigue development and respiratory rates ( Marconnet , 1992

to the better swimming performance of Brycon amazonicusto ... contributeto the better swimming performance of Brycon amazonicus

to muscle pain and lowers performanceleadsto muscle pain and lowers performance

local tissue acidosis that potentially modulates the activity of proteases that decompose extracellular matrix , thereby liberating amino acids that are consumable for energy generation ( 28can causelocal tissue acidosis that potentially modulates the activity of proteases that decompose extracellular matrix , thereby liberating amino acids that are consumable for energy generation ( 28

to increased perfusion pressure and effects on accumulation leading to increased perfusion pressure and effects on contractility of coronary arteriesleadingto increased perfusion pressure and effects on accumulation leading to increased perfusion pressure and effects on contractility of coronary arteries

from a combination of excess formation and decreased utilization of lactateresultsfrom a combination of excess formation and decreased utilization of lactate

muscular paincausesmuscular pain

to acidification of the mediacan leadto acidification of the media

a pH fall in platelet concentrates ( PC ) during storage ... and this phenomenon causes platelet morphological lesions and loss of platelet in vivo viabilitymay causea pH fall in platelet concentrates ( PC ) during storage ... and this phenomenon causes platelet morphological lesions and loss of platelet in vivo viability

your muscles to burncausesyour muscles to burn

pain during exercise ( the feared quad burncausespain during exercise ( the feared quad burn

in a fall in intracellular pH. Depletion of glycogen storesresultingin a fall in intracellular pH. Depletion of glycogen stores

back pain and a burning sensation during intense exercisecausesback pain and a burning sensation during intense exercise

during exercise and in the patients in the studycreatedduring exercise and in the patients in the study

muscles to stop workingcausesmuscles to stop working

the muscles to tire and sorecausesthe muscles to tire and sore

in a decrease of pH which is responsible for the excess damage in brains [ 12resultedin a decrease of pH which is responsible for the excess damage in brains [ 12

to local fluid accumulation and increases in the light - scattering effects commonly observed during epithelial hypoxia ( 88leadsto local fluid accumulation and increases in the light - scattering effects commonly observed during epithelial hypoxia ( 88

the intra - cellular acidification of muscle(passive) caused bythe intra - cellular acidification of muscle

a burning sensation in muscles during physical exertiondoes causea burning sensation in muscles during physical exertion

from BG , an energy source for metabolically active neurons ( 43originatingfrom BG , an energy source for metabolically active neurons ( 43

microenvironmental acidification , destroys the intercellular matrix , and enhances metastatic spreadcausesmicroenvironmental acidification , destroys the intercellular matrix , and enhances metastatic spread

if acetyl - CoA concentrations continues to rise during high intensity exercisecan resultif acetyl - CoA concentrations continues to rise during high intensity exercise

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