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Smart Reasoning:

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Qaagi - Book of Why

Causes

Effects

CNsupresultedin less ( p<0.05 ) lactate accumulation

enough oxygencausingblood lactate accumulation

a factorinfluencesthe rate of lactate accumulation

end - organ hypoperfusion(passive) may be caused byLactate accumulation in sepsis

anaerobic energy sourcesresultingin blood lactate accumulation

The impairment of mitochondrial function can lead to reduced ATP production and lactate production concurrent with a decrease in lactate metabolismresultingin lactate accumulation

by ischemia [ Strauss , Puffenberger , Morton , unpublished observation(passive) caused bycerebral lactate accumulation

by ischemia [ Strauss , Puffenberger , Morton , unpublished observation].(passive) caused bycerebral lactate accumulation

ischemia [ Strauss , Puffenberger , Morton , unpublished observation(passive) caused bycerebral lactate accumulation

While not specific for sepsiswill causelactate release

how many of themshould leadto a lactate build up

an even pacecausesa build - up of lactate

impaired pyruvate metabolismleadingto lactate accumulation

Otherwise known as " Onset of Blood Lactate Accumulation " or " anaerobic threshold " , this is the level at which more lactate is produced in your body than what can be utilizedcausinga build - up of lactate

ATP ... anaerobic glycolysisleadsto accumulation of lactate

anaerobic metabolismleadsto lactate accumulation

by anaerobic metabolism(passive) caused bylactate accumulation

the depletion of oxygen and glucosecausesthe accumulation of lactate

pyruvate metabolismleadingto lactate accumulation

Enhanced anaerobic glycolysiscausesthe accumulation of lactate

aerobic metabolismcausinglactate accumulation

Acid inhibition on lactate - consuming speciesledto lactate accumulation

In addition , glycolysis was uncoupled from glucose oxidationresultingin accumulation of lactate

that the production of lactic acid often exceeds clearanceresultingin lactate accumulation

oxygen - independent ATP re - synthesisresultsin lactate accumulation

excess glucosecausingan accumulation of lactate

metabolismleadingto lactate accumulation

enhance peripheral lactate productionleadingto lactate accumulation

aerobic glycolysisleadingto lactate accumulation

conditionscausinglactate accumulation

This processresultsin accumulation of lactate

The ensuing uncoupling between glucose oxidation and glycolysisleadsto accumulation of lactate

the TCA cyclecontributesto lactate accumulation

to pyruvateresultingin lactate accumulation

This metabolic changeleadsto accumulation of lactate

in turnleadsto lactate accumulation

a conditionresultingfrom the accumulation of lactate

aerobic respirationleadingto lactate accumulation

The Krebs cycleresultsin lactate accumulation

by damage to mitochondria(passive) caused byan accumulation of lactate

an increased concentration of hydrogen ions and a decrease in pH.causesan increased concentration of hydrogen ions and a decrease in pH.

sincecan causesince

failure ... and reduce productivitywill causefailure ... and reduce productivity

to myocardial protectioncontributesto myocardial protection

muscles to stop workingcausesmuscles to stop working

to [ A]. increase in pHleadsto [ A]. increase in pH

an increase in acidity in the tumor microenvironmentcausesan increase in acidity in the tumor microenvironment

a burning sensation in the musclescausesa burning sensation in the muscles

a decline in blood phcausinga decline in blood ph

a reduction in performancewas causinga reduction in performance

from a combination of excess formation and decreased utilization of lactateresultsfrom a combination of excess formation and decreased utilization of lactate

a metabolic acidosis ( Russell and Hino 1985 ; Nocek 1997provokesa metabolic acidosis ( Russell and Hino 1985 ; Nocek 1997

the decrease in pH(passive) caused bythe decrease in pH

fatiguecausesfatigue

to physical fatigueleadsto physical fatigue

additional neuronal dysfunctioncan causeadditional neuronal dysfunction

muscular fatiguedoes ... causemuscular fatigue

muscular fatiguemay causemuscular fatigue

acidosiscan causeacidosis

to acidosiscontributesto acidosis

to muscle fatigue and sorenessleadsto muscle fatigue and soreness

in pyruvate accumulation in cancer cellsalso resultsin pyruvate accumulation in cancer cells

tiredness and sorenesscausestiredness and soreness

muscular paincausesmuscular pain

to cellular acidificationwould leadto cellular acidification

from the activity of lactate - producing bacteriaresultedfrom the activity of lactate - producing bacteria

from a combination of excess formationresultsfrom a combination of excess formation

the acidity(passive) caused bythe acidity

during exercisecausesduring exercise

in a fall in intracellularresultingin a fall in intracellular

to the dreaded muscle burnwould ... leadto the dreaded muscle burn

the acidity in your muscle cells to risecausesthe acidity in your muscle cells to rise

The illness(passive) is caused byThe illness

from glycolysisresultingfrom glycolysis

to a blockade of the glycolytic pathwayleadsto a blockade of the glycolytic pathway

to a blockade of the glycolytic pathwayleadsto a blockade of the glycolytic pathway

cramps , nausea , weakness , and exhaustioncausescramps , nausea , weakness , and exhaustion

The muscle pain(passive) caused byThe muscle pain

to acidification of the mediacan leadto acidification of the media

The low pH(passive) was caused byThe low pH

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Smart Reasoning:

C&E

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