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Qaagi - Book of Why

Causes

Effects

Quick relax times are the bestcausea lot of lactate

Short break periods are the topcausea lot of lactate

by novel mutations in the EARS2 gene(passive) caused byhigh lactate

inhibition of respiration with antimycin(passive) caused bylactate production

gut dysbiosis(passive) is caused byhigh lactate

the fluoroquinolones(passive) caused bylactate production

many more things than velocity ... so(passive) is influenced bylactate production

conditionscausinglactate accumulation

the pathwayleadingto L - lactate

any process which causes tissue to use anaerobic respiration(passive) can be caused byA raised lactate

lots of conditionscauseelevated lactate

to monitor tumor size in patients with Glioblastoma Multiforme , an aggressive form of brain tumor(passive) was designedA lactate biosensor

of two subunits ( LDHA and LDHB(passive) is composedLactate dehydrogenase

structurally(passive) is ... composedLactate dehydrogenase

of four subunits ( tetramer(passive) is composedLactate dehydrogenase

expressing a gene from an anaerobic bacterium Clostridiumresultingin secreted lactate

by oxygen deficiency to cells(passive) can be caused bylactate

by oxygen deficiency to cells(passive) can be causedlactate

a build up of pyruvate from glycolysisresultsin lactate

Anaerobic workout ... intensive enoughto resultin lactate

by oxygen deficiency(passive) can be causedlactate

a metabolic pathwayleadingto lactate

diminished pyruvate flux through the citric acid cycle(passive) caused bylactate

hypoperfusion of any tissue(passive) may be caused byLactate

by tumor metabolism(passive) caused bylactate

a build ... glycolysisresultsin lactate

by metformin(passive) caused bylactate

by gluconeogenesis(passive) caused bylactate

protein clearanceleadingto lactate

the major pyruvate consuming pathwayleadingto lactate

enoughto resultin lactate

Respiratory chain defectsusually resultin Lactate

Respiratory chain defectsresultin Lactate

The increase incauseslactate

This increase ofcauseslactate

by hypoxia(passive) caused byLactate

by intense exercise(passive) caused bythe lactate

The decrease appearsto have resultedfrom lactate

the high acidity levelsresultingfrom the lactate

Any increase in effort or speed above this levelwill causelactate

other side effects not listed belowmay causeother side effects not listed below

only from pyruvateoriginatesonly from pyruvate

vasodilation in vitrocausesvasodilation in vitro

a small but significant increase in Hc - O2 affinitycauseda small but significant increase in Hc - O2 affinity

from glycolysisresultsfrom glycolysis

to decreased tumor cell proliferationleadingto decreased tumor cell proliferation

in an accumulation of lactate and lactic acidosisresultingin an accumulation of lactate and lactic acidosis

to higher cellular lactate levelsleadingto higher cellular lactate levels

fatigue ... and there is NO lactate thresholddoes ... causefatigue ... and there is NO lactate threshold

in elevated lactate production and reduced gluconeogenic substrate pyruvate levelsresultingin elevated lactate production and reduced gluconeogenic substrate pyruvate levels

to an elevated lactate / pyruvate ratioleadingto an elevated lactate / pyruvate ratio

the hydrogen ions in the muscle to increasecausesthe hydrogen ions in the muscle to increase

to rapid fatigue if the lactate is not removedleadsto rapid fatigue if the lactate is not removed

to rapid fatigue if the lactate is not removed it should beleadsto rapid fatigue if the lactate is not removed it should be

muscle fatigue and acidosiscan causemuscle fatigue and acidosis

to lactic acidosis ( serum pHmay leadto lactic acidosis ( serum pH

in intracellular acidosis with low pH.resultingin intracellular acidosis with low pH.

in issues in Individuals who have poor D - lactate metabolismcan resultin issues in Individuals who have poor D - lactate metabolism

to intracellular acidosisleadsto intracellular acidosis

pH to decreasecausespH to decrease

pain when it accumulates in musclescan causepain when it accumulates in muscles

muscle fatigue and paincan causemuscle fatigue and pain

extra energy for these muscle instead of causing muscle fatiguecan causeextra energy for these muscle instead of causing muscle fatigue

a elevated anion gap metabolic acidosiscausesa elevated anion gap metabolic acidosis

to fatigue during high intensity anaerobic workleadsto fatigue during high intensity anaerobic work

fatiguedoes ... causefatigue

fatiguecan causefatigue

fatiguecausesfatigue

fatiguecausesfatigue

the fatigueis ... causingthe fatigue

fatiguedoes ... causefatigue

fatigue icausesfatigue i

to fatigueleadsto fatigue

fatiguecausesfatigue

to muscle exhaustionleadingto muscle exhaustion

in an accumulation of lresultingin an accumulation of l

from muscle anaerobic glycolysis and conversionresultedfrom muscle anaerobic glycolysis and conversion

an accumulation of H+. The increase incausesan accumulation of H+. The increase in

acidosisdoes ... causeacidosis

an acidosiscausesan acidosis

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