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Qaagi - Book of Why

Causes

Effects

The disease ... was foundto causeiron accumulation in the brain and neurodegeneration

by genetic defects in the ceruloplasmin gene(passive) is caused byneurodegeneration with brain iron accumulation

that malformed blood vesselscauseincreased deposition of iron in the brain

blockages in the veins leading from the headmay causeiron deposits to develop in the brain

diseasecausingabnormal iron deposits in the brain

ferritin mutationsleadto excessive iron deposition in the brain

is actually caused by narrowing veins in the Central Nervous Systemcausingiron deposits to be left in the brain

PANTOTHENATE KINASE DEFICIENCY ( PANK2causesNEURODEGENERATION WITH BRAIN IRON

a genetic disordercausesiron to build up in the brain

a release of hemecontributesto the build - up of brain iron

Pank 2causesiron to build up in the brain

UB study findscan influenceiron levels in brain

Pank 2 ... a rare genetic disordercausesiron to build up in the brain

that iron overload in the body does not appearto resultin brain iron accumulation

by abnormal processing , stability , and catalytic activity of mutant pantothenate kinase 2(passive) caused bybrain iron accumulation

abnormal processing , stability , and catalytic activity of mutant pantothenate kinase 2(passive) caused bybrain iron accumulation

by abnormal processing , stability , and catalytic activity of mutant pantothenate kinase(passive) caused bybrain iron accumulation

Abstract [ en ] Age and sexcan influencebrain iron levels

A synthesis in neurodegeneration withcausedbrain iron accumulation

Over the last decades , studies from our laboratory and other groups using animal models have shown that iron overload ,resultingin iron accumulation in the brain

that these patients have always stenosis in the jugular veinscausingiron accumulation in the brain

by PANK2 gene mutation(passive) caused bybrain iron accumulation

High level of ferritin serum or hemosiderosisleadsto iron deposition in body

Excess consumptioncan leadto iron deposits in the brain

The destruction of haemoglobincausesiron to be released into the brain

inflammationresultingfrom the iron deposition into the brain

I do know thatcausesiron deposits on brain

the mechanismcausingbrain iron deposition

a backup of bloodleadsto iron deposits in the brain

an increased ferritin synthesiscould ... contributeto iron deposition in the brain

loss of CP(passive) caused byiron - mediated neurodegeneration

The activation of IRP1 ... an increased ferritin synthesiscould ... contributeto iron deposition in the brain

This leakagemay leadto deposition of iron in the brain

a rare nerve diseasecausesiron to accumulate in the brain

The diseasecausesiron to accumulate on the brain

money ... the disordercausesiron to accumulate in the brain

Heart diseasecan leadExcess iron deposition in the myocardium

to the breakdown of heme from neuronal Hb(passive) can be contributedAccumulation of iron within the brain

by surface corrosion(passive) caused byiron deposition in the HRSG

iron overloadcan resultin pancreatic iron deposition

to heart failureleadto heart failure

in neurodegenerationcan resultin neurodegeneration

MSmight causeMS

multiple sclerosismay causemultiple sclerosis

multiple sclerosis ... as this article saysmay causemultiple sclerosis ... as this article says

a cascade events of oxidative stress and neuroinflammation that destroy neuronal phospholipid membranes , proteins and nucleic acids , leading to the degeneration and death of neuronsmay causea cascade events of oxidative stress and neuroinflammation that destroy neuronal phospholipid membranes , proteins and nucleic acids , leading to the degeneration and death of neurons

to damage of neuronal dopaminergic functionleadsto damage of neuronal dopaminergic function

in increased oxidative stresscan resultin increased oxidative stress

to an earlier onset of the diseaseleadsto an earlier onset of the disease

to neurodegenerationleadsto neurodegeneration

neurodegeneration(passive) caused byneurodegeneration

for examplecausedfor example

to Alzheimer 's diseasemay contributeto Alzheimer 's disease

a central nervous system disorder(passive) caused bya central nervous system disorder

lesionscausedlesions

to cytokine release leading to inflammation or fibrosismay contributeto cytokine release leading to inflammation or fibrosis

a vast range of disorders of the central nervous systemcan causea vast range of disorders of the central nervous system

cellular dysregulation , including neuronal damagecan causecellular dysregulation , including neuronal damage

neurodegenerative problemscausingneurodegenerative problems

hyperpigmentation and skin bronzingcauseshyperpigmentation and skin bronzing

in symptoms of fatiguecan resultin symptoms of fatigue

oxidative stress(passive) caused byoxidative stress

to cardiac dysfunctionmay leadto cardiac dysfunction

to heart failureleadingto heart failure

heart failuremay causeheart failure

heart failuredoes ... causeheart failure

to cardiac dysfunction in patients with iron overloadmay leadto cardiac dysfunction in patients with iron overload

to arrhythmias and ventricular failuremay leadto arrhythmias and ventricular failure

a very uncommon type of deafness(passive) is causeda very uncommon type of deafness

to oxidative stress response in the SNcould contributeto oxidative stress response in the SN

in cardiomyopathyresultingin cardiomyopathy

by modifying environmental factors , such as how much red meat and iron dietary supplements we consume and ... in women ... having hysterectomies beforemay be influencedby modifying environmental factors , such as how much red meat and iron dietary supplements we consume and ... in women ... having hysterectomies before

by modifying environmental factors , such as how much red meat and iron dietary supplements we consume and ... in women ... having hysterectomies before menopausemay be influencedby modifying environmental factors , such as how much red meat and iron dietary supplements we consume and ... in women ... having hysterectomies before menopause

to enlargement and elevation in liver enzymes threeleadsto enlargement and elevation in liver enzymes three

to enlargement and elevation in liver enzymes ( Figure threeleadsto enlargement and elevation in liver enzymes ( Figure three

organ damagecausesorgan damage

to damage by free radicals ... and the accumulation of glutamate leads to damage by excitotoxicityleadsto damage by free radicals ... and the accumulation of glutamate leads to damage by excitotoxicity

seizurescausesseizures

symptoms of multiple sclerosiscan causesymptoms of multiple sclerosis

pituitary hypogonadismcan causepituitary hypogonadism

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