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Qaagi - Book of Why

Causes

Effects

Research demonstratedresultedfrom one insertion mutation

Analysis revealedresultedfrom one insertion mutation

Deletion or insertion of three or a multiple of three base pairs inside coding sequencesdoes ... causeframeshift mutation

a novel deleterious homozygous four - nucleotide deletioncausingframeshift mutation

by insertion or deletion(passive) caused byframeshift mutation

Genetic analysis demonstratedresultedfrom a single insertion mutation

Genetic analysis revealedresultedfrom a single insertion mutation

exon 6causesframeshift mutation

Research demonstratedresultedfrom a single insertion mutation

that may insert between bases in DNAcausingframeshift mutation

INT-407 cellsresultingfrom an insertion mutation of cj1461

a variety of agents known as mutagens which may be chemical compounds(passive) may be caused byPoint mutation

a mutagencausesframeshift mutation

The breakcausesframeshift mutation

This mechanismcould causeframeshift mutation

likely(passive) would ... be causedI368N mutation

DNA mismatch repair deficiency is observed in about 15 % of human colorectal , gastric , and endometrial tumors and in lower frequencies in a minority of other tumorscausinginsertion / deletion mutations

the potentialto causeinsertion mutations in oncogenes

Abou Jamra R.leadsMAN1B1 mutation

DNAcan causeinsertion mutations

the probability of this sequence occurring ... DNAcan causeinsertion mutations

mobile genetic elementscauseinsertion mutations

A build - up of DNA adductscausesinsertion mutations

a potentialto causeinsertion mutations

All the above splice defect andresultedinsertion mutations

All deletions ( except the deletion in intron 5 ) andcausedinsertion mutations

Virusescan causeinsertion mutations

A T - DNA and adjacent flanking sequences containing the gene of interest could be inserted into a second locuscausingan insertion mutation

transposition(passive) caused byinsertion mutations

Mechanisms by which SCN5Acausesmutation N1325S

by inserting DNA that should not be there(passive) caused byInsertion - mutation

inserting into a segment of genomic DNAthereby causingan insertion mutation

the first diseasecausinggermline mutation

Another benefit that they have ... the host cellcould leadto insertion mutation

reverse slippagewill resultin an insertion mutation

a novel Leigh syndromecausingNDUFS3 mutation

insertion of new genetic material into a normal gene , particularly of retroviruses into chromosomal DNA(passive) caused bymutation

A mousewill causeMecp2-null mutation

A mousecausesMecp2-null mutation

A. A mousecausesMecp2-null mutation

the Dna to get longerwill causethe Dna to get longer

a frame shift and a premature termination of protein synthesiscausea frame shift and a premature termination of protein synthesis

to a frame shift in the coding sequenceleadsto a frame shift in the coding sequence

severe defectscausedsevere defects

defects in gliding motilitycauseddefects in gliding motility

Which disease(passive) can be caused byWhich disease

a shift of the open reading frame and formed a termination codon early at Amino Acid Positioncauseda shift of the open reading frame and formed a termination codon early at Amino Acid Position

in reduced activity of the protein encoded by the genemay resultin reduced activity of the protein encoded by the gene

in a frame shift that caused a stop codon to appear 18 amino acid residues downstream from the insertionresultedin a frame shift that caused a stop codon to appear 18 amino acid residues downstream from the insertion

premature truncation of the proteincausingpremature truncation of the protein

to the development of a number of inherited diseaseshave ledto the development of a number of inherited diseases

in potential polar effects on downstream genesresultingin potential polar effects on downstream genes

a shift in the reading framecausea shift in the reading frame

the gene to code for protein so long that it can not fold properlymay causethe gene to code for protein so long that it can not fold properly

in the production of the wrong amino acidsresultin the production of the wrong amino acids

to cancerleadto cancer

in a null phenotyperesultin a null phenotype

a frameshiftCausesa frameshift

a complete change of the first transmembrane domaincauseda complete change of the first transmembrane domain

in the addition of extra DNAresultin the addition of extra DNA

in the addition of extra DNAresultin the addition of extra DNA

a frameshift mutationWill ... causea frameshift mutation

with a premature stop codonresultingwith a premature stop codon

in a premature stop codonresultsin a premature stop codon

1 or more amino acids to be added to a proteincauses1 or more amino acids to be added to a protein

in shorter proteins being formedresultin shorter proteins being formed

complete loss or severe reduction in the level of full lengthcausescomplete loss or severe reduction in the level of full length

more defects ... than a point mutationdoes ... causemore defects ... than a point mutation

a frame shiftcausesa frame shift

a complete change of the first transmembrane domain ... and deletion of the remaining six transmembrane domains ( Figure 3causeda complete change of the first transmembrane domain ... and deletion of the remaining six transmembrane domains ( Figure 3

from a duplication mutationhad resultedfrom a duplication mutation

neural differentiation or cause cancerinfluenceneural differentiation or cause cancer

in some nucleotides being gainedresultin some nucleotides being gained

usually ... than point mutationcausesusually ... than point mutation

the amino acid change from ser ( Serine ) to glu ( Glutamatecausesthe amino acid change from ser ( Serine ) to glu ( Glutamate

to a frameshiftleadingto a frameshift

usuallycausesusually

the 6 bp larger band(passive) caused bythe 6 bp larger band

to Li - Fraumeni syndromeleadsto Li - Fraumeni syndrome

conformational disturbance(passive) caused byconformational disturbance

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