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Smart Reasoning:

C&E

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Qaagi - Book of Why

Causes

Effects

that one consequence of these changes is a reduced phosphorylation of nuclear matrix - associated DNA topoisomerase IIresultingin an inhibition of the activity of this enzyme

the binding of the effectorcausesinhibition of the enzyme action

high levels of nanoparticlesmay ... leadto inhibition of enzyme activities

Treatment with bafilomycin A1causedinhibition of lysosomal activity

product accumulationcould causeinhibition of enzyme exercise

product accumulationmay causeinhibition of enzyme exercise

the enzyme - bound - ligand ... a high molecular weight receptorresultsin inhibition of enzymatic activity

Bronidoxcausesinhibition of enzyme activity in bacteria

The 50 % presence of the R309Q PHKG2 mutant subunitcausedcomplete inhibition of PhK enzyme activity

that binds with high affinity and specificity to the catalytic site of telomeraseresultingin competitive inhibition of enzyme activity

to bind to a specific epitope on the enzymedoes ... causeenzyme inhibition

Activation of enzymes Inhibition of enzymes In therapeutic drugscausinginhibition on enzymes

some other site on the proteinleadingto allosteric inhibition of enzyme activity

The presence of millimolar concentrations of this ionresultedin marked inhibition of the enzyme activity

flavonoidsleadingto the inhibition of enzyme activity [ 26,52

soluble lignin - derived compoundsmay ... causeenzyme inhibition

the proteinleadingto allosteric inhibition of enzyme activity

by rna interference(passive) caused byenzyme inhibition

1can causeenzyme inhibition

a substance resembling substrate molecule through blocking its active site(passive) caused byEnzyme inhibition

It has been knownto causeinhibition of the [ [ enzyme

the substratecausinginhibition of the enzyme

These data ... multiple polyphenols in GEcould be contributingto the inhibition of DGAT1 enzyme activity

Carbamate pesticidescan causeinhibition of the acetylcholinesterase enzyme

strong oxidationcausesinhibition of the enzyme

by a substance resembling substrate molecule(passive) caused byEnzyme inhibition

or not ASPIRINcausesENZYME INHIBITION

Organophosphorus agents ( OPs ) , such as pesticides and chemical warfare agentscan causeenzyme inhibition of acetylcholinesterase

adenylate cyclase in membranes of GH3 cells ... rather appearedto causeinhibition of the enzyme

feed ingredientscausingenzyme inhibition

by grapefruit juice ingestion(passive) caused byenzyme inhibition

Saponinscan causeenzyme inhibition

or not METHOTREXATEcausesENZYME INHIBITION

or not LISINOPRILcausesENZYME INHIBITION

by a substance resembling(passive) caused byEnzyme inhibition

Sildenafil citratecausesinhibition of this enzyme

the conditions for enzyme modification ... thoseresultin the inhibition of the enzyme activity

administration of sitagliptinledto inhibition of DPP-4 enzyme activity

the minimal effect of L - serine bindingleadingto inhibition of enzyme activity

a reaction ... the enzymeresultsin inhibition of enzyme activity

to arrest of DNAleadsto arrest of DNA

to arrest of DNA synthesis and cell deathleadsto arrest of DNA synthesis and cell death

in death of the parasiteresultsin death of the parasite

to arrest of DNA synthesis and cell deathleadsto arrest of DNA synthesis and cell death

to an increase in the content of noradrenaline and serotonin in the brain , which in turn eliminates the biochemical cause of depressionleadsto an increase in the content of noradrenaline and serotonin in the brain , which in turn eliminates the biochemical cause of depression

thereforemay ... influencetherefore

to arleadsto ar

generallyleadsgenerally

to inactivation ( Tao et al . , 2010may leadto inactivation ( Tao et al . , 2010

in reduced cytoprotectionresultedin reduced cytoprotection

to drug interactionsleadsto drug interactions

acetaldehyde build up , which leads to unpleasant effectscausesacetaldehyde build up , which leads to unpleasant effects

to acetylation of histone and non - histone proteinsleadsto acetylation of histone and non - histone proteins

relaxation of smooth muscles of corpus cavernosum of thecausesrelaxation of smooth muscles of corpus cavernosum of the

levelsresultedlevels

in an increase in the concentration of cAMPresultingin an increase in the concentration of cAMP

to increases in D - serine levels and a reduction in the formation of toxic D - serine oxidation productscan leadto increases in D - serine levels and a reduction in the formation of toxic D - serine oxidation products

reduced metabolism of drugs and their subsequent accumulation within the bodycan causereduced metabolism of drugs and their subsequent accumulation within the body

a decrease in the accumulation of sorbitol in the cellscausesa decrease in the accumulation of sorbitol in the cells

a rise in intracellular levels of cAMP which is believed to result in cell deathcausesa rise in intracellular levels of cAMP which is believed to result in cell death

to an increase in the intracellular concentration of sodium and thus ( by stimulation of sodium - calcium exchangeleadsto an increase in the intracellular concentration of sodium and thus ( by stimulation of sodium - calcium exchange

to an increase in the intracellular concentration of sodium and thus ( by stimulation of sodium - calcium exchange ) an increase in the intracellular concentration of calciumleadsto an increase in the intracellular concentration of sodium and thus ( by stimulation of sodium - calcium exchange ) an increase in the intracellular concentration of calcium

to an increase in the intracellular concentration of sodiumleadsto an increase in the intracellular concentration of sodium

to inhibition of protein biosynthesisleadsto inhibition of protein biosynthesis

to reduced cholesterol synthesisleadsto reduced cholesterol synthesis

in abrogation ofresultedin abrogation of

to loss of drug efficacyleadingto loss of drug efficacy

increase in concentration , not justcan ... causeincrease in concentration , not just

to accumulation of squalene inside the fungal cells , depletion of ergosterolleadsto accumulation of squalene inside the fungal cells , depletion of ergosterol

increased accumulation of SAHcausesincreased accumulation of SAH

in increased transcriptionresultedin increased transcription

increase in concentration , not just lengthcan ... causeincrease in concentration , not just length

to inhibition of lithium effectsleadsto inhibition of lithium effects

to lower levels of blood cholesterol , fatty acids and lipids , improved insulin sensitivity and reduced formation of glucose in the liverleadsto lower levels of blood cholesterol , fatty acids and lipids , improved insulin sensitivity and reduced formation of glucose in the liver

in increasedresultedin increased

to an increaseleadsto an increase

to toxic levels of reactive oxygen species ( ROS ) which can damage DNA , proteins and lipids inside of the cellleadsto toxic levels of reactive oxygen species ( ROS ) which can damage DNA , proteins and lipids inside of the cell

increases in the intracellular concentrations ofcan causeincreases in the intracellular concentrations of

to decreasedleadsto decreased

to an enhancement in systemic drug exposuremay leadto an enhancement in systemic drug exposure

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Smart Reasoning:

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