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Qaagi - Book of Why

Causes

Effects

to inhibit PDK1causingindirect inhibition of mTORC1

DZNep ... a known S - adenosylhomocysteine ( AdoHcy ) hydrolase inhibitor ,leadsto the indirect inhibition of S - adenosyl - methionine

phospholipase A2 ( PLA2(passive) caused byInhibition of indirect hemolysis

excites parvalbumin - expressing interneurons ( PVINs ) through 5-HT2A receptorsleadingto indirect perisomatic inhibition of PNs

Similarly , AMPK phosphorylates the tuberin proteinleadingto indirect inhibition of the mTOR pathway

An increase in Ta might result in increased VPDleadingto the indirect inhibition of GEP

Most of these drugs act by interfering signaling between growth factors and receptors known for assisting tumor growththereby leadingto indirect inhibition of angiogenesis

over - expression of follistatinleadsto the indirect inhibition of myostatin

osteoblastsresultingin an indirect inhibition of osteoclastogenesis

the potentiation of the A2A receptor and inhibition of D2 receptor signaling ( Nishi et al . , 2008 , 2011causesthe potentiation of the A2A receptor and inhibition of D2 receptor signaling ( Nishi et al . , 2008 , 2011

to overinhibition of GPe , disinhibition of STN , and increased excitation of GPi / SNrleads sequentiallyto overinhibition of GPe , disinhibition of STN , and increased excitation of GPi / SNr

to the trademark excessive momentsleadto the trademark excessive moments

substrate from getting to it , or binding to the enzyme and changing its shape or conformation enough to distort the active sitepreventssubstrate from getting to it , or binding to the enzyme and changing its shape or conformation enough to distort the active site

from an extrinsic sourceoriginatingfrom an extrinsic source

the inhibition of HNP1-stimulated IL-6 and IL-8 secretion by high concentrations of wortmannin(passive) was caused bythe inhibition of HNP1-stimulated IL-6 and IL-8 secretion by high concentrations of wortmannin

with GABAergic cellsoriginatingwith GABAergic cells

a change in membrane conductance without a major change in current flow [ 63causea change in membrane conductance without a major change in current flow [ 63

to S9 phosphorylationleadingto S9 phosphorylation

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