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Smart Reasoning:

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Qaagi - Book of Why

Causes

Effects

vWF multimersleadingto increased platelet aggregation / thrombosis

plateletscausingan increase in platelet aggregation

ASPIRIN ... other drugscausePLATELET AGGREGATION INCREASED

any drugcausingPLATELET AGGREGATION INCREASED

nitric oxide production and prostacyclin synthesisresultingin increased platelet aggregation

by high levels of thromboxane a2(passive) caused byIncreased platelet aggregation

high levels of thromboxane a2(passive) caused byIncreased platelet aggregation

other drugscausePLATELET AGGREGATION INCREASED

These changeswould leadto an increase in platelet aggregation

Inhibit cyclooxygenaseleadingto increased platelet aggregation

Drugsmay causeincreased platelet counts

IBUPROFEN ... other drugscausePLATELET AGGREGATION INCREASED

It is postulatedmay resultin increased platelet aggregation

catecholamines released in response to pain(passive) caused byIncreased platelet aggregation

Cocainealso leadsto increased platelet aggregation

This situation , called hyperlipidemia and hypertriglyceridemiacausesan increase in platelet aggregation

which suggestcausesgreater platelet aggregation

the synthesis of thromboxane A2 ... arachidonic acid in plateletsleadsto decreased platelet aggregation

Reduction of thromboxanescausingreduced platelet aggregation

by in vivo activation(passive) caused byDecreased platelet aggregation

NANSAIDs(passive) caused byreduced platelet aggregation

ASPIRIN ... other drugscausePLATELET AGGREGATION DECREASED

other drugscausePLATELET AGGREGATION DECREASED

ASPIRINcausingPLATELET AGGREGATION DECREASED

IBUPROFEN ... other drugscausePLATELET AGGREGATION DECREASED

t lymphocytesmay ... causedecreased platelet aggregation

the associated formation of thromboxaneleadsto enhanced platelet aggregation

a serotonin increase ... in turnmight provokeenhanced platelet aggregation

increased synthesis of TXA2may contributeto the enhanced platelet aggregation

NO production ... bothcontributesto enhanced platelet aggregation

It is now knownto causeenhanced platelet aggregation

NO destruction , or bothcontributesto enhanced platelet aggregation

TXA2may contributeto the enhanced platelet aggregation

pro - inflammatory markerscontributeto increasing platelet aggregation

Hypoglycaemia is knownto resultin enhanced platelet aggregation

In a study in pigs , benefits of normothermic ex vivo liver perfusion over static cold storage in reducing ischaemia / reperfusion injury in transplanted livers were shownto resultfrom reduced platelet aggregation

Adenosine diphosphate ( ADP ) and thrombin are then released from the activated platelets and thromboxane A2 is generatedcausingplatelet aggregation

by platelet activation factors , collagen , ADP and so on(passive) caused byplatelet aggregation

flow provoked increased endothelial vWF secretion in the stenotic outlet regioncontributingto exacerbated platelet aggregation

by ADP , arachidonic acid and collagen(passive) caused byplatelet aggregation

to vascular complicationsleadingto vascular complications

when it 's not needed in the bodycauseswhen it 's not needed in the body

to an increased risk of clottingmay leadto an increased risk of clotting

thrombosiscausingthrombosis

to clotscan leadto clots

to pathogenesisleadingto pathogenesis

clots and plaque formationcausesclots and plaque formation

to strokes and heart attackscan leadto strokes and heart attacks

wound healing problemscan also causewound healing problems

in blood vessel changesresultingin blood vessel changes

an increased likelihood of blood clottingcausesan increased likelihood of blood clotting

to thrombus formationleadingto thrombus formation

to the hyperthrombic state in smokerscontributesto the hyperthrombic state in smokers

thrombosiscausingthrombosis

blood clotscan causeblood clots

in platelet plug formingis resultingin platelet plug forming

to thrombosis and clot formationcan leadto thrombosis and clot formation

to thrombosisleadingto thrombosis

to blood clotsleadto blood clots

in clot formation in blood vessels ( atherosclerosisresultsin clot formation in blood vessels ( atherosclerosis

to inflammationmay leadto inflammation

in intravascular thrombosisresultingin intravascular thrombosis

to blood clotsleadsto blood clots

heart attacks and strokescauseheart attacks and strokes

to formation of atherosclerosis and acute platelet thrombus formationcontributesto formation of atherosclerosis and acute platelet thrombus formation

vessel occlusion that blocks blood flowcan causevessel occlusion that blocks blood flow

to increased thrombus formationleadingto increased thrombus formation

formation of blood clotscan causeformation of blood clots

in the formation of blood clotscan resultin the formation of blood clots

to the formation of blood clotscontributesto the formation of blood clots

thrombosis and myocardial infarctioncan causethrombosis and myocardial infarction

in increased risk of bleeding eventsresultingin increased risk of bleeding events

an increased risk of bleeding eventscausingan increased risk of bleeding events

increased risk of bleeding eventscausingincreased risk of bleeding events

blood clots to formcan causeblood clots to form

heart attack , stroke and venous thrombosiscausesheart attack , stroke and venous thrombosis

an increased risk of bleedingwould causean increased risk of bleeding

to bleeding complicationsmay leadto bleeding complications

to thrombus formationleadingto thrombus formation

in thrombus formationresultingin thrombus formation

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Smart Reasoning:

C&E

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