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Qaagi - Book of Why

Causes

Effects

Negative iron balanceinitially leadsto depletion of iron stores in the bone marrow and an associated decrease in serum ferritin

In the first stage , body iron requirement exceeds iron intakecausingprogressive depletion of bone marrow iron stores

In the first stage , iron requirement exceeds intakecausingprogressive depletion of bone marrow iron stores

Hepcidin 25 induces the internalization and degradation of ferroportin ,resultingin increased intracellular iron stores

Inflamed dripcausingincreased bone marrow myeloid elements

Iron supplements in the elderlymay causean increase in iron stores

combinationmay causeincreased bone marrow depressionTaxol

the red blood cells and insignificant intake of ironcan causeanemia that depletes the bone marrow

a hormonecausesbone marrow to make red blood cells

enough amount of erythropoietin ( a hormonecausesbone marrow to make red blood cells

by the treatment(passive) caused byincreased bone marrow erythropoiesis

ONX 0914ledto an increased mobilization of monocytes from the bone marrow

several causes , such as recent administration of chemotherapy or granulocyte - colony stimulating factor ( G - CSF ) and anemiacan leadto the diffusely increased bone marrow

Anemia of inflammatory ( or chronic ) diseasemay also resultin increased bone marrow hemosiderin

red cellsResultingin anaemia Bone marrow

eventcausesthe bone marrow to increase

Exercisecausesan increase in bone marrow

The disease ... a rare blood cancercausesthe overproduction of blood cells in bone marrow

Diabetesleadsto enhanced bone marrow adipogenesis

the blood ... the kind of cellscausebone marrow to grow

hyperplasiaresultingin expansion of bone marrow

erythroid hyperplasiaresultingin expansion of bone marrow

Thalassemiamay causebone marrow to expand

Alpha thalassemiacan causebone marrow to expand

Beta thalassemiacan causebone marrow to expand

Thalassaemiamay causebone marrow to expand

MCsoriginatefrom a multipotent hematopoietic progenitors in bone marrow

cancer from other organscan causemetastases in bone marrow

to multiply in an abnormally rapidthereby causingoverproduction in the bone marrow

to multiply in an abnormally rapidcausingoverproduction in the bone marrow

These cellsoriginatefrom monocytes in the bone marrow

Monocytesoriginatefrom progenitors in bone marrow

MCsoriginatefrom a bone marrow progenitor

of mostly ironbecoming composedof mostly iron

in a reduced use of intravenous iron therapy and an increased efficacy of oral iron therapycould resultin a reduced use of intravenous iron therapy and an increased efficacy of oral iron therapy

in thrombocytopeniaresultingin thrombocytopenia

Little iron(passive) is discoveredLittle iron

to the increased production of red blood cellscan also leadto the increased production of red blood cells

to decreased osteoblast differentiationleadsto decreased osteoblast differentiation

in pancytopeniaresultsin pancytopenia

immature neutrophils(passive) caused byimmature neutrophils

in the deficiency of all types of blood cellsresultsin the deficiency of all types of blood cells

to lower resistance to infectionleadsto lower resistance to infection

in thrombocytopeniaresultingin thrombocytopenia

to an increase in LT - HSC release from the bone marrow niche and differentiation to ST - HSCs and hematopoietic progenitor cells ( 37 , 46leadsto an increase in LT - HSC release from the bone marrow niche and differentiation to ST - HSCs and hematopoietic progenitor cells ( 37 , 46

a chronic hematological disorder(passive) caused bya chronic hematological disorder

An increased neutrophil count(passive) is usually caused byAn increased neutrophil count

An increase in circulating neutrophil number(passive) could be caused byAn increase in circulating neutrophil number

the unpleasant side effects are fewercausingthe unpleasant side effects are fewer

medications * effectcausingmedications * effect

the unpleasant side effectscausingthe unpleasant side effects

A group of disorders(passive) caused byA group of disorders

in pain and functional improvementresultedin pain and functional improvement

bones to widencausesbones to widen

blood(passive) caused byblood

skeletal damagecausingskeletal damage

to oxidative stress and DNA damage in hematopoietic stem / progenitors carrying a Csf3r truncation mutationcontributeto oxidative stress and DNA damage in hematopoietic stem / progenitors carrying a Csf3r truncation mutation

in reduced hemoglobin synthesis and consequently to anemia and iron storage in peripheral tissuesresultsin reduced hemoglobin synthesis and consequently to anemia and iron storage in peripheral tissues

in reduced hemoglobin synthesis and consequently to anemia and iron storage in peripheral tissuesresultsin reduced hemoglobin synthesis and consequently to anemia and iron storage in peripheral tissues

to deathleadsto death

in painmay resultin pain

it to failcausingit to fail

to polycythemialeadingto polycythemia

from hepatocellular carcinomaoriginatingfrom hepatocellular carcinoma

anemia ( uh - nee - me - uh , a low red blood cell countcausinganemia ( uh - nee - me - uh , a low red blood cell count

from the endothelial cellswere originatingfrom the endothelial cells

in decreased blood cell counts , which can then lead to serious infections , fatigue , bleeding , andcan resultin decreased blood cell counts , which can then lead to serious infections , fatigue , bleeding , and

lymphoma or leukemia and sending vast numbers of diseased cells into the lymph or circulatory systemscausinglymphoma or leukemia and sending vast numbers of diseased cells into the lymph or circulatory systems

in decreased blood cell counts , which can then lead to serious infections , fatigue , bleeding , and death.6,10,13can resultin decreased blood cell counts , which can then lead to serious infections , fatigue , bleeding , and death.6,10,13

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Smart Reasoning:

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