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Qaagi - Book of Why

Causes

Effects

factorscontributingtowards immune tolerance

by the tumor(passive) caused byimmune tolerance and immunosuppression

by HIV(passive) is causeda low immunity tolerance

metabolic reprogramming in a tumorcan contributetowards immune tolerance

to work by targeting only those T cells that are already causing disease(passive) are designedImmune tolerance therapies

the dysregulation of individual miRNAs in T cellscan contributeto impaired immune tolerance

Move Free is supposedto contributeto normal immune tolerance

Liver ... immune tolerancecan leadto systemic immune tolerance

that will further inhibit the responseleadingto infectious immune tolerance

Increased checkpoint signalingmay leadto HCC immune tolerance

by multiple systems(passive) caused byimmune system tolerance

one or more genetic variantscauseaneuploidy tolerance

to reprogram the immune system to stop the disease - causing immune attack on self - tissue while maintaining the immune system 's ability to fight infection(passive) are designedImmune tolerance therapies

to stop , or even prevent , the autoimmune disease while leaving the body 's disease - fighting abilities intact(passive) are designedImmune tolerance therapies

Once activated , these regulatory T cells could be a factor that limited the activity of effector T cells and triggered high - level functional IDO expression in immune tissues , thenresultingin immune tolerance

responses to tumor associated antigens , such as interruption of T - cell down regulatory pathwayscontributeto immune tolerance

responses to tumor associated antigens , such as interruption of T - cell ... regulatory pathwayscontributeto immune tolerance

the maturation of DCs and a tumor - specific T cell responseleadsto immune tolerance

a tumor - specific T cell responseleadsto immune tolerance

presentation of antigen to T cells in the livercan leadto immune tolerance

a suppressive immune response , which yields tolerance and oral feedingcausesantigenic immune tolerance

associated antigens , such as interruption of T - cell down regulatory pathwayscontributeto immune tolerance

T - cell response in patientsleadsto immune tolerance

regulatory T ( Treg ) cellssetimmune tolerance

by regulatory T cells ( Tregs(passive) caused byimmune tolerance

cells and processescontributingto immune tolerance

triggered high - level functional IDO expression in immune tissues , thenresultingin immune tolerance

this signalling ... regulatory T cellsleadsto immune tolerance

early oral exposuremay leadto immune tolerance

This lack of exposurecould resultin immune tolerance

The allergen - specific memory T and B cell responses are alteredleadingto immune tolerance

antigens ... which are knownto causeimmune tolerance

T cellswill causeimmune tolerance

These cellscontributeto immune tolerance

T cellsleadingto immune tolerance

factorscontributeto immune tolerance

Excessive antigencould leadto immune tolerance

induce T - cells apoptosisleadingto immune tolerance

induces the apoptosis of T cellsleadingto immune tolerance

The mechanisms by whichcontributeto immune tolerance

to the development of multiple pro - tolerogenic immunotherapies including : CTLA4Ig ( the first FDA - approved drug targeting T - cell co - stimulation to treat autoimmune disease and organ transplantation ) , a nhas ledto the development of multiple pro - tolerogenic immunotherapies including : CTLA4Ig ( the first FDA - approved drug targeting T - cell co - stimulation to treat autoimmune disease and organ transplantation ) , a n

to autoimmune diseasesleadsto autoimmune diseases

autoimmune reactioncausesautoimmune reaction

IDRscan causeIDRs

antigenswhere ... originateantigens

in a very high rate of transient errors and a potential for processor failureresultingin a very high rate of transient errors and a potential for processor failure

with Dr. Jay Skylerleadswith Dr. Jay Skyler

to prevent disease - causing immune responsesdesignedto prevent disease - causing immune responses

to inflammationcontributingto inflammation

to demyelination and substantial neurodegenerationleadingto demyelination and substantial neurodegeneration

to the development of autoimmune diseases such as rheumatoid arthritis ( RAcan leadto the development of autoimmune diseases such as rheumatoid arthritis ( RA

to autoimmune manifestationsleadingto autoimmune manifestations

to the development of anti - rejection drugsleadto the development of anti - rejection drugs

to tumoral immune resistancecontributingto tumoral immune resistance

to an effective therapeutic vaccineleadingto an effective therapeutic vaccine

a chronic inflammatory response in the mucosa of the small intestine with symptoms such as diarrhea , steatorrhea and weight losscausesa chronic inflammatory response in the mucosa of the small intestine with symptoms such as diarrhea , steatorrhea and weight loss

to the development of autoimmune conditionsmay leadto the development of autoimmune conditions

to impaired immune developmentcould leadto impaired immune development

Human allergic reactions(passive) are often caused byHuman allergic reactions

to the development of autoimmune diseasesleadto the development of autoimmune diseases

to new techniques that overcome transplant rejection and prevent GVHDwill leadto new techniques that overcome transplant rejection and prevent GVHD

to new techniques that overcome transplant rejection and prevent GVHDwill leadto new techniques that overcome transplant rejection and prevent GVHD

to the development of pathogenic autoimmunitycan ... leadto the development of pathogenic autoimmunity

to development of Multiple Sclerosis ( MSleadingto development of Multiple Sclerosis ( MS

in damage to normal tissueresultsin damage to normal tissue

to tissue dysfunction and damageleadingto tissue dysfunction and damage

in autoimmune responsescould ... resultin autoimmune responses

to increased platelet destructionleadingto increased platelet destruction

to an autoimmune reaction against thyroid auto - antigens and the development of ATleadingto an autoimmune reaction against thyroid auto - antigens and the development of AT

no systemic immune response to the antigencausesno systemic immune response to the antigen

to systemic autoimmunityleadingto systemic autoimmunity

to poor antibody responsesledto poor antibody responses

to autoimmunityleadsto autoimmunity

to autoimmunityleadingto autoimmunity

with the immune systemcausingwith the immune system

the immune system(passive) is causedthe immune system

to autoantibody productionleadingto autoantibody production

from a number of causes includingcan resultfrom a number of causes including

to the inappropriate survival of autoreactive B cells producing pathogenic antibodies and sustained inflammationleadingto the inappropriate survival of autoreactive B cells producing pathogenic antibodies and sustained inflammation

from two processesresultsfrom two processes

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