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Qaagi - Book of Why

Causes

Effects

Anti thyroid drugs in high dosescan leadto hypothyroidism in fetus

transplacental passage of antithyroid drugs ( ATD ) , which influence fetal thyroid much more than the maternal glandcan causefetal hypothyroidism

intravascular administration of non - ionic iodinated contrast agents(passive) caused byfetal hypothyroidism

Treatment with antithyroid drugsmay causefetal hypothyroidism

Aim of treatment ... mild limitto preventfetal hypothyroidism

an attemptto preventfetal hypothyroidism

CNS development Contrast ◦ Excessive iodide uptake by the fetal thyroidcan causefetal hypothyroidism

Overtreatmentmay causeiatrogenic fetal hypothyroidism

Both iodine deficiency and congenital hypothyroidism , due to absence , malpositioning , underdevelopment , or failure to make thyroid hormonescan causefetal hypothyroidism

Iodine deficiency while you are pregnantcan causefetal hypothyroidism

that the lowest possible dose in the mother should be usedto preventfetal hypothyroidism

that , on rare occasions , can block these receptorsthereby causingfetal hypothyroidism

the potentialto causefetal hypothyroidism

Nsaidscausefetal hypothyroidism in %

The use of levothyroxine in combination with tireostatikami contraindicatedcan causefetal hypothyroidism

propylthiouracil administration to the mother(passive) caused byfetal hypothyroidism

preferential placental transfer of antithyroid drugwill causefetal hypothyroidism

the FT4 levelsto preventfetal hypothyroidism

Ifpossible , drugs that primarily inhibit ion flux through potassium channelsmay causefetal hypothyroidism

maternal graves ’ disease(passive) caused byfetal goitrous hypothyroidism

outcome evaluation newly diagnosed , asymptomatic patientsmay causefetal hypothyroidism

the TSH receptor antibodies ... the fetuspreventsfetal hypothyroidism

Daily iodine intake of more than 500 - 1100 µg gcan triggerfetal hypothyroidism

diuretics Radioiodine : absolute CIcausesfetal hypothyroidism

Potassium iodide is contraindicated during pregnancymay causefetal hypothyroidism

Blocking antibodiescan causefetal hypothyroidism

the disproportionate transfer of antithyroid drugmay causefetal hypothyroidism

Contraindications : Lactationmay causehypothyroidism in infant

Amiodarone should be avoided given Amiodarone 's proclivityto causefetal hypothyroidism

Excess maternal intake of iodinecan causefetal hypothyroidism

Close monitoring is recommended with PTU administration as overcorrectioncan potentially causefetal hypothyroidism

low thyroid during fetal development(passive) caused bythe fetus -congenital hypothyroidism

Propylthiouracil is given in lowest dose , less than 150 mgdailyto preventfetal hypothyroidism

inflammation of a suprapubic cathetermay causefetal hypothyroidism

bradycardia , prolongation of QT interval Overall summary of amiodarone Dangerous in the setting of prolonged QT , pregnancy ( Class D àmay causefetal hypothyroidism

treatment with ATDs in the mothercan ... causehypothyroidism in the fetus

Since ra- dioactive iodine is contraindicated in pregnancy , propthiouracil may be used carefully since blocking dosesmay causefetal hypothyroidism

As discussed under Antenatal diagnosis , antenatal hypothyroidism is relatively rareto discoverhypothyroidism in utero

adverse effects maintenance dose schedule for pediatric patientsmay causefetal hypothyroidism

quantitycan causegoitrous hypothyroidism in the fetus

in elevated plasma insulin and leptin concentrations and overgrowth of PAT in the fetusresultedin elevated plasma insulin and leptin concentrations and overgrowth of PAT in the fetus

from transplacental passage of antithyroid medication used to treat the mothercan also resultfrom transplacental passage of antithyroid medication used to treat the mother

to hydramniosleadingto hydramnios

to chylothorax and hydrops fetaliscan leadto chylothorax and hydrops fetalis

the normal fall in fetal glucose oxidation observed in response to short - term fasting of pregnant ewespreventsthe normal fall in fetal glucose oxidation observed in response to short - term fasting of pregnant ewes

in severe mental retardationresultingin severe mental retardation

alsomay ... resultalso

to reduced cognitive performance in offspring as well as other effects on neural development in both humans and experimental animalsleadsto reduced cognitive performance in offspring as well as other effects on neural development in both humans and experimental animals

to IUGR , goiter , and impaired psychomotor developmentmay leadto IUGR , goiter , and impaired psychomotor development

to reduced cognitive performance in offspring as well as other effects on neural development in both … ( More ) Áine M. Duffy , Jose Morales - Corraliza , +4 authors Helen E Scharfmanleadsto reduced cognitive performance in offspring as well as other effects on neural development in both … ( More ) Áine M. Duffy , Jose Morales - Corraliza , +4 authors Helen E Scharfman

in irreversible brain damagecan resultin irreversible brain damage

from administration of antithyroid drugs to the motherhas resultedfrom administration of antithyroid drugs to the mother

fetal goitercausingfetal goiter

the development of thicker and more closely spaced trabeculaecausedthe development of thicker and more closely spaced trabeculae

from placental passageresultingfrom placental passage

the increases in heart rate , cardiac output , blood pressure , and systemic blood flow normally observed in newborn lambs in the hours after deliveryalso preventsthe increases in heart rate , cardiac output , blood pressure , and systemic blood flow normally observed in newborn lambs in the hours after delivery

to brain damage Seaweed and other ocean plantsleadsto brain damage Seaweed and other ocean plants

neurological problems(passive) caused byneurological problems

significant changes to the structure and strength of bone in the fetuscausessignificant changes to the structure and strength of bone in the fetus

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