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Qaagi - Book of Why

Causes

Effects

Administration of exogenous corticosteroidsleadsto suppression of the HPA axis

axis suppression - long - term steroid usecan causesuppression of the HPA axis

Use of exogenous glucocorticoids is knownto causesuppression of the HPA axis

ELOCON Cream 0.1 %causedHPA axis suppression

The duration of treatment with corticosteroidsresultsin HPA axis suppression

axis suppression , use of clobetasol propionate shampoo , 0.05 %resultedin demonstrable HPA axis suppression

axis suppression , use of CLOBEX ( clobetasol propionate ) Shampoo , 0.05 %resultedin demonstrable HPA axis suppression

chronic stress that erodes the body ’s resilience and metabolic reserve(passive) is triggered byHPA axis dysregulation

Prednisone , methylprednisolone , dexamethasone , equivalent dose.75 , mineralocorticoid potency.5 0 , biological half - life , daily dosecausingHPA axis suppression

many different aspects of the modern lifestyle , including poor diet , sleep deprivation , chronic stress , lack of ( or too much ) exercise , and inflammation(passive) is caused byHPA axis dysregulation

While our literature review indicated the possibility of a multifactorial origin of the child 's growth retardation , the use of topical corticosteroids was shownto have contributedto suppression of the HPA axis

http://www.e-ijd.org/text.asp?2015/60/2/194/152529 Long term application of topical corticosteroids in cases of psoriasishas resultedin HPA axis suppression

hypo perfusion / ischemiacould causehpa axis dysregulation

Given that reduced perfusioncan causehpa - axis dysregulation

High potency eczema treatments ... the suppression of your body ’s stress response systemcould leadto HPA Axis Suppression

Significant absorption into the bodycan causeHPA axis suppression

Prolonged usemay causeHPA axis suppression

systemic absorptioncan causeHPA axis suppression

Inflammation ... in turnmay influenceHPA axis uncoupling

less likelyto causeHPA axis suppression

GlucocCorticosteroidsmay causesuppression of the HPA axis

SPScausingHPA axis dysregulation

high‐dose glucocorticoidscan causeHPA axis suppression

their potential for adverse systemic events ... to whichcauseHPA - axis suppression

the steroids ( and licoriceare causingsuppression of the HPA axis

an acute stress , a series of traumas , illness , and/or(passive) can be triggered byHPA - axis dysregulation

Exogenous steroids ( glucocorticoidsresultin HPA axis suppression

long time glucocorticoid usecausessuppression of the HPA axis

as therapy and supraphysiology dose of prednisone are expectedto causesuppression in HPA - axis

little , if any , tendencyto causeHPA - axis suppression

14 g a week ... the ‘ minimumto causeHPA axis suppression

a threshold dose for all ICSwill causeHPA axis suppression

physical and emotional stress(passive) is caused byHPA axis suppression

steroid treatment for another condition(passive) caused byHPA axis suppression

management or monitoring precautionmay leadto HPA - Axis suppression

Yeah , and to go back a little bit what we were talking about before which was alcohol , and smoking , those kinds of things , that ’s actually been shownto causeHPA axis dysregulation

avid absorption in a disrupted skin barriermay leadto suppression of HPA axis

increased GR sensitivitycausinghyper - suppression of HPA axis

hypersecretion of corticotropin - releasing hormone(passive) probably caused byHPA axis hyperreactivity

the many factorsinfluenceHPA - axis suppression

to adrenal crisis.• Contact dermatitis : Allergic contact dermatitis can occurmay leadto adrenal crisis.• Contact dermatitis : Allergic contact dermatitis can occur

to adrenal crisis.• Immunosuppressionmay leadto adrenal crisis.• Immunosuppression

to adrenal crisis.• Hypersensitivitymay leadto adrenal crisis.• Hypersensitivity

hyper andcauseshyper and

from chronic HPA axis activationcan resultfrom chronic HPA axis activation

hydration dysregulationmay ... causehydration dysregulation

to negative effects on memory processesleadsto negative effects on memory processes

in hypoglycemia , low bloodtherefore resultingin hypoglycemia , low blood

to cortisol deficiencyleadsto cortisol deficiency

to broad endocrine dysruption / failure and secondary organ failureleadsto broad endocrine dysruption / failure and secondary organ failure

high cytokines which shutdown t3 receptorscauseshigh cytokines which shutdown t3 receptors

to low levels of serum cortisolleadingto low levels of serum cortisol

to increased frequency and/or severity of infections and systemic inflammationmay contributeto increased frequency and/or severity of infections and systemic inflammation

in reduced cortisol responseresultingin reduced cortisol response

Cushing 's syndrome or adrenocortical insufficiency(passive) caused byCushing 's syndrome or adrenocortical insufficiency

Iatrogenic AI(passive) is caused byIatrogenic AI

high or low cortisol levels(passive) caused byhigh or low cortisol levels

a moment about the hitch pivot axis HPA that can transfer weight from the rear end of the implement frame 9 to the front end of the implement frame 9 , thereby reducing the frame weight carried by each rear frame wheel 11R and increasing the frame weight carried by each front frame wheel 11F. [ 0036createa moment about the hitch pivot axis HPA that can transfer weight from the rear end of the implement frame 9 to the front end of the implement frame 9 , thereby reducing the frame weight carried by each rear frame wheel 11R and increasing the frame weight carried by each front frame wheel 11F. [ 0036

in the upregulation of corticosteroneresultsin the upregulation of corticosterone

dysglycemiacausesdysglycemia

in what is called adrenal fatigueresultingin what is called adrenal fatigue

to immune challengecontributingto immune challenge

to significant morbidity and mortalitycan leadto significant morbidity and mortality

to both of the above ... as well ascan leadto both of the above ... as well as

The circadian rhythm problems(passive) are caused byThe circadian rhythm problems

impaired cortisol productioncausesimpaired cortisol production

in symptoms of depressionresultingin symptoms of depression

CRFmay causeCRF

to illness , which then leads to further suppression of the HPA axisleadingto illness , which then leads to further suppression of the HPA axis

excess cortisol leading to breaking down proteins ( muscle tissue ) to increase my glucose levels ( protein converted to glucose in the liver called Gluconeogenesisresultingexcess cortisol leading to breaking down proteins ( muscle tissue ) to increase my glucose levels ( protein converted to glucose in the liver called Gluconeogenesis

depression or whether the emotional disturbances present in the disorder result in stress dysregulationcausesdepression or whether the emotional disturbances present in the disorder result in stress dysregulation

the etiology and therapy of geriatric depressionto influencethe etiology and therapy of geriatric depression

lack of energy and other adrenal fatigue symptomscauseslack of energy and other adrenal fatigue symptoms

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Smart Reasoning:

C&E

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