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other situationsinfluencehepatic clearance ( Table
Immature hepatic enzyme functionleadsto reduced hepatic clearance
Immature hepatic enzyme functionleadsto reduced hepatic clearance
reportcausesreduced hepatic clearance
perfusioncausinghepatic ischaemia.[7],[8],[9
many factorsmay influencehepatic and renal clearance
In the livercontributingto extensive hepatic clearance
deposition of amyloid in various organs(passive) is caused byHepatic amyloidosis Amyloidosis
Normal aging ... many factorsmay influencehepatic and renal clearance
Amyloidosis(passive) is causedHepatic amyloidosis
Acute parvovirus infectioncan causehepatic necrosis
the hepatocyte proteinscausinghepatic necrosis
Fulminant viral hepatitis ( A , B , C , Dmay causehepatic thrombosis
Approximately 4 % of acetaminophen ... a toxic metabolitecauseshepatic necrosis
a disease of broiler chickens ... several toxic factorscausehepatic necrosis
when taken in large amounts or overdosecausinghepatic necrosis
the insultcausinghepatic necrosis
extensive EBV proliferation in the RES of the liver(passive) caused byHepatic necrosis
how ... convergeto causehepatic necrosis
Fasciola hepatica(passive) caused byhepatic trematodoses
Vector designinfluenceshepatic genotoxicity
systemic clearanceresultsfrom hepatic clearance
Even worse , it only takes 0.5 grams per 2 pounds of body weightto causehepatic necrosis
the fraction of systemic clearanceresultsfrom hepatic clearance
two factors : the rate of hepatic blood flow ( which reflects the delivery of a drug to the liver ) and how efficiently a drug is removed from the blood(passive) is influenced byHepatic clearance
1 mgcausehepatic clearance
a systemsare designedthe hepatic clearance
factorsinfluencinghepatic metastases
by dexamethasone(passive) caused byhepatic clearance
Unbound fraction and enzyme activitymay influencethe hepatic clearance
Many liver diseasescausehepatic siderosis
other drugscauseHEPATIC ISCHAEMIA
neuroendocrine tumors(passive) caused byhepatic metastases
any drugcausingHEPATIC SEQUESTRATION
ASPIRIN ... other drugscauseHEPATIC ISCHAEMIA
FOLIC ACIDcausesHEPATIC SEQUESTRATION
The HBx gene of hepatitis B viruscan influencehepatic microenvironment
FOLIC ACID ... other drugscauseHEPATIC SEQUESTRATION
cirrhosiscausinghepatic hydrothorax
by properties(passive) caused byhepatic insufficiency
in decreased busulfan AUCresultingin decreased busulfan AUC
to this processcontributesto this process
a decrease in free fatty acids but no change in insulin responsemay causea decrease in free fatty acids but no change in insulin response
a decrease in free fatty acidsmay causea decrease in free fatty acids
in the morbidity from infectionresultedin the morbidity from infection
to hepatosplenomegaly and/or portal hypertensioncan leadto hepatosplenomegaly and/or portal hypertension
prurituscan causepruritus
to a lack of correlation between membrane permeability , absorption and bioavailabilityleadsto a lack of correlation between membrane permeability , absorption and bioavailability
an increase in blood levelscausingan increase in blood levels
liver dysfunction and sometimes failurecausesliver dysfunction and sometimes failure
his livercausedhis liver
to the development of hepatic encephalopathy and hepatic comacan leadto the development of hepatic encephalopathy and hepatic coma
rarelycausesrarely
drug accumulationcan causedrug accumulation
deathhave may causedeath
from various infectious and non - infectious diseasescan resultfrom various infectious and non - infectious diseases
to serumleadingto serum
from other causes ( e.g. metastatic liverresultingfrom other causes ( e.g. metastatic liver
to liver failureoften leadsto liver failure
to the discovery of novel therapeutic targets to treat metabolic disorders and aid in weight loss maintenancecould leadto the discovery of novel therapeutic targets to treat metabolic disorders and aid in weight loss maintenance
to QT prolongationmay leadto QT prolongation
to an increase in portal pressureleadsto an increase in portal pressure
in a decrease in the half - liferesultingin a decrease in the half - life
rarelycausesrarely
to hypophosphatemiacontributesto hypophosphatemia
pulmonary inflammationcausingpulmonary inflammation
from your GI tract , breast , and lung(34most generally originatefrom your GI tract , breast , and lung(34
to thrombosisleadingto thrombosis
acne - like lesions(passive) caused byacne - like lesions
from a wide range of primary tumours ( e.g. colorectal- , breast- and neuroendocrine tumourscan originatefrom a wide range of primary tumours ( e.g. colorectal- , breast- and neuroendocrine tumours
from Enterobius vermicularisresultingfrom Enterobius vermicularis
alsomay ... contributealso
to painful hepatomegaly , liver failure , heart failure or portal hypertensionleadingto painful hepatomegaly , liver failure , heart failure or portal hypertension
from cancer of the large bowel , the lungs , the kidneys , the breast , the pancreas , the stomach or the ovaries or from melanomas , sarcomas , neuroendocrine tumours , soft tissue tumours , etcmay originatefrom cancer of the large bowel , the lungs , the kidneys , the breast , the pancreas , the stomach or the ovaries or from melanomas , sarcomas , neuroendocrine tumours , soft tissue tumours , etc
shortness of breathcausingshortness of breath