These mutationsresultin different hemoglobin structural variants ( structural hemoglobinopathies ) or in a decreased globin chain synthesis ( thalassemia

by mutations in the hemoglobin genes(passive) caused byabnormal structural hemoglobin variants ... , and the thalassemias , which are caused by an underproduction of otherwise normal hemoglobin molecules

Cytoskeletal perturbationleadsto platelet dysfunction and thrombocytopenia in variant forms of Glanzmann thrombasthenia

Cytoskeletal perturbationleadsto platelet dysfunction and thrombocytopenia in variant forms of Glanzmann thrombasthenia

Deoxygenation of SS erythrocytesleadsto intracellular hemoglobin polymerization , loss of deformability and changes in cell morphology

treatmentsdesignedto increase more effective hemoglobin variants and decrease abnormal variants

Diverse signal transduction pathways impinging on the N - terminal tails of histonesleadto a number of post - translational modifications including acetylation , phosphorylation , poly(ADP - ribosylation ) , ubiquitination and methylation

Gresele P. Cytoskeletal perturbationleadsto platelet dysfunction and thrombocytopenia in variant forms of Glanzmann thrombasthenia

It can also be usedto discovergenomic mutations including short indels and structural variants

Experimentsdesignedto study splice variants , epigenetic modifications ( methylation ) and

Such phenotypic variationmay resultfrom polymorphic differences or epigenetic modifications in genes associated with cyanogenesis

monitoring treatmentsdesignedto extend more effective hemoglobin variants and decrease abnormal variants

Activated caspase-8 and caspase-9 further initiate activation of the caspase cascadeleadingto biochemical and morphological changes associated with apoptosis

structural genescausethe formation of hemoglobin variants , and - or regulatory genes

This substitutionleadsto various structural and functional changes in the hemoglobin molecule

treatmentsdesignedto extend simpler hemoglobin variants and reduce abnormal variants

oily substancescomposedof carotenoid isomers ( chemical derivatives ) of xanthophyll called lutein and zeaxanthin

More severe protein oxidationcausesa formation of chemically modified derivatives

the most known diseaseresultingfrom a structural hemoglobin variant

by mutations in the globin genes(passive) caused byhemoglobin variants

the globin genesleadingto hemoglobin variants

amino acid substitutions in either globin chain(passive) are caused byThe hemoglobin variants

genomic sequence changesleadingto hemoglobin variants

by globin gene mutations(passive) caused byhemoglobin variants