Loading ...
Professor Martyn Cobourneis leadingresearch into the sonic hedgehog signaling gene
an oral drugdesignedto block abnormal Hedgehog pathway signaling
Other consistent mutationsleadto constitutive activation of the hedgehog pathway
Jervine ... a naturally occuring steroidal alkaloidcausescyclopia by blocking sonic hedgehog signaling
steroidal alkaloidcausescyclopia by blocking sonic hedgehog signaling
by PTCH1 inactivation(passive) caused byConstitutive activation of hedgehog signaling
mutations of a membrane receptor known as Smoothened , an essential link permitting the activation of the Hedgehog pathway(passive) can be caused byMalfunctions affecting the Hedgehog pathway
that DL is a hypomorphic allele of Ptch1leadingto increased Hedgehog signaling
protein levelscausingactivation of hedgehog signaling
a large increase in shha transcription(passive) was caused bythe elevated Hedgehog signaling in Sox11-deficient zebrafish
a German research teamdiscoveredanother hedgehog signaling pathway
Mutationsleadto the activation of hedgehog signalling
Conditional Kif3a ablationcausesabnormal hedgehog signaling topography
basaloid hamartomasresultingfrom Hedgehog pathway hyperactivity
by inactivation of the mouse complex(passive) caused bythe sonic hedgehog pathway
who is carrying her pysanky egghas designedto show a hedgehog
first(passive) was ... discoveredHedgehog ( Hh ) pathway
Our data are consistent with this , with loss of WDR60 resulting in aberrant accumulation of Smo in cilia ,leadingto perturbed hedgehog signaling
new mutationsinfluenceHedgehog signaling
new mutantsinfluencehedgehog signaling
an oral small moleculedesignedto inhibit the Hedgehog signaling pathway
four mutationsinfluenceHedgehog signaling
Loss of Bmpr1a in MSCsleadsto downregulation of hedgehog
neural patterningresultingfrom Hedgehog signaling
defects in neural patterningresultingfrom Hedgehog signaling
human caudal dysgenesis disordersmay resultfrom dysregulation of hedgehog signaling pathways
the cilia ... a distinctive calcium area within cellssetup Hedgehog pathways
a mannerinfluencedby the canonical Hedgehog signaling pathway
first(passive) was ... discoveredThe Hedgehog signaling pathway
to the growth and survival of human osteosarcoma cellsto contributeto the growth and survival of human osteosarcoma cells
to cancer cell growth and survivalleadsto cancer cell growth and survival
what craniofacial effectcauseswhat craniofacial effect
the cancer(passive) caused bythe cancer
to cancer cell growth and survival ... as well as to define its association with treatment failureleadsto cancer cell growth and survival ... as well as to define its association with treatment failure
tumorigenesis(passive) caused bytumorigenesis
to an increase in Snail protein expression and a decrease in [ [ E - cadherinleadsto an increase in Snail protein expression and a decrease in [ [ E - cadherin
the body developmentinfluencesthe body development
to an increase in Snail protein expression and a decrease in E - cadherin and tightleadsto an increase in Snail protein expression and a decrease in E - cadherin and tight
to an increase in Snail protein expression and a decrease in E - cadherin and Tight Junctionsleadsto an increase in Snail protein expression and a decrease in E - cadherin and Tight Junctions
to an increase in Angiogenic Factors ( angiopoietin-1 and angiopoietin-2leadsto an increase in Angiogenic Factors ( angiopoietin-1 and angiopoietin-2
to the pathogenesis of human gastrointestinal stromal tumors via GLI - mediated activation of KIT expressioncontributesto the pathogenesis of human gastrointestinal stromal tumors via GLI - mediated activation of KIT expression
to the pathogenesis of human gastrointestinal stromal tumors via GLI - mediated activation of KIT expressioncontributesto the pathogenesis of human gastrointestinal stromal tumors via GLI - mediated activation of KIT expression
to an increase in Angiogenic Factors ( angiopoietin-1 and angiopoietin-2),[52leadsto an increase in Angiogenic Factors ( angiopoietin-1 and angiopoietin-2),[52
the differentiation of various tissuesinfluencesthe differentiation of various tissues
increased expression of PDGF - A in zebrafish larvae ... providing a previously unrecognized link between PDGF and the Hedgehog pathwaycausedincreased expression of PDGF - A in zebrafish larvae ... providing a previously unrecognized link between PDGF and the Hedgehog pathway
to the pathogenesis of human gastrointestinal stromal tumorscontributesto the pathogenesis of human gastrointestinal stromal tumors
Mutations in this gene pathwaymay contributeMutations in this gene pathway
several cancerscan causeseveral cancers
to GLI - dependent transcriptional activation of target genes , such as GLI1 , PTCH1 , CCND2 , FOXL1 , JAG2 and SFRP1leadsto GLI - dependent transcriptional activation of target genes , such as GLI1 , PTCH1 , CCND2 , FOXL1 , JAG2 and SFRP1
basal cell carcinoma , the most common skin cancer and one of the most common cancerscausesbasal cell carcinoma , the most common skin cancer and one of the most common cancers
alsomay ... contributealso
to alterations in ADAMTS5 expression and cartilage degradationleadingto alterations in ADAMTS5 expression and cartilage degradation
to cell survival , maintenance , and metastasisleadingto cell survival , maintenance , and metastasis
to tumor growthcontributesto tumor growth
developmentalcausesdevelopmental
to the survival and maintenance of T - ALL cellscan contributeto the survival and maintenance of T - ALL cells
human tumors and because there is a large set of human inherited syndromes ( the ciliopathiescauseshuman tumors and because there is a large set of human inherited syndromes ( the ciliopathies
cancercausingcancer
to basal cell carcinomaleadto basal cell carcinoma
in Drosophiladiscoveredin Drosophila
in a 50 to 60 percent reduction in tumor sizeresultedin a 50 to 60 percent reduction in tumor size
redeployment of the dorsal - ventral axis of the injured neural tube ... allowing generation of new neural crest - like cellscausedredeployment of the dorsal - ventral axis of the injured neural tube ... allowing generation of new neural crest - like cells
to breast cancer developmentmay contributeto breast cancer development
in severe acrania - holoprosencephaly - agnathia craniofacial defectsresultingin severe acrania - holoprosencephaly - agnathia craniofacial defects
other disease types(passive) influenced byother disease types
to the initiation of some cancerscontributesto the initiation of some cancers
a breakdown of the normal regenerative properties of the lung airways , leading to degenerative disease statescausesa breakdown of the normal regenerative properties of the lung airways , leading to degenerative disease states
in severe acraniaholoprosencephaly - agnathia craniofacial defectsresultingin severe acraniaholoprosencephaly - agnathia craniofacial defects
to excessive NPC proliferationleadingto excessive NPC proliferation