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Qaagi - Book of Why

Causes

Effects

T lymphocytes ... the same cellscausegraft versus host disease ( GVHD

The cells are irradiatedto preventgraft - versus - host disease

the t - cells ... only the onescausegraft versus host disease

the toxic cellstriggergraft - versus - host disease

Those cells are engineeredto preventgraft versus host disease ( GVHD

the activated T - cellscausinggraft - versus host disease ( GVHD

munoregulatory T cellspreventgraft - versus - host - disease

engineered T - cellsto causegraft versus host disease

transfer of allogeneic T cellscan causegraft versus host disease ( GvHD

some light ... the immune cellscausegraft - versus - host disease ( GVHD

the immune cells ... when they startcausinggraft versus host disease

the donor T cells ... to helppreventgraft versus host disease

the elimination of pre - T - cellscausegraft versus host disease ( GvHD

Engineered regulatory T cellspreventgraft - versus - host disease

Figure 7 from Ex vivo - expanded CD4+CD25 + immunoregulatory T cellspreventgraft - versus - host - disease

Figure 3 from Ex vivo - expanded CD4+CD25 + immunoregulatory T cellspreventgraft - versus - host - disease

Figure 6 from Ex vivo - expanded CD4+CD25 + immunoregulatory T cellspreventgraft - versus - host - disease

Figure 4 from Ex vivo - expanded CD4+CD25 + immunoregulatory T cellspreventgraft - versus - host - disease

blood cells ... measuresto preventgraft - versus - host disease

donor T cells reacting against(passive) caused bygraft - versus - host disease ( GVHD

the ability to eliminate the T cellsshould ... causeGraft - versus - host disease

Certain types of T cellscausegraft - versus - host disease

transplanted unmatching cellscausing“ graft vs host ” disease

CAR - T cells ... to avoidtriggeringgraft - versus - host - disease ( GVHD

metabolic pathways ... the T cellscausegraft - versus - host disease ( GVHD

using iNK T cellsto preventgraft versus host disease

T - cells ... a kind of lymphocytecausesGraft Versus Host Disease

Allogeneic stem cellsespecially ... may causegraft versus host disease

A disadvantage of these white blood cells iscan ... provokegraft versus host disease

inactivating white blood cellsto preventgraft - versus - host disease

Strober S. Host NKT cellscan preventgraft - versus - host disease

T regulatory cells ( Tregs ... to helppreventgraft - versus - host disease ( GVHD

Haploidentical stem cells ... to helppreventgraft versus host disease ( GVHD

the white blood cells will attack the patientcausinggraft - versus - host disease ( GVHD

The NK cells have decreased potentialto causegraft - versus - host disease

M. Weyand Mature donor T cellscausegraft - versus - host disease ( GVHD

regulatory T cells ( Tregs ) have been shownto effectively preventgraft - versus - host disease ( GVHD

the infusion of MHC - mismatched allogeneic T cellsmay causegraft - versus - host disease ( GVHD

Early infusion of T regulatory Cellsto preventGraft Versus Host Disease

freshly purified T - regulatory cellsto preventgraft - versus - host disease

significant morbidity and mortality in allogeneic hematopoietic stem cell transplantation ( aHSCTcausessignificant morbidity and mortality in allogeneic hematopoietic stem cell transplantation ( aHSCT

significant morbidity and mortality in patients receiving transplants containing allogeneic hematopoietic cellscausessignificant morbidity and mortality in patients receiving transplants containing allogeneic hematopoietic cells

morbidity and mortality after HSCTcausesmorbidity and mortality after HSCT

multiple organ failure(passive) caused bymultiple organ failure

in substantial morbidity and mortalityresultsin substantial morbidity and mortality

severe morbidity and mortality(passive) caused bysevere morbidity and mortality

significant morbidity and mortality among the transplanted patientscausessignificant morbidity and mortality among the transplanted patients

to transplant - related morbidity and mortalitycontributes substantiallyto transplant - related morbidity and mortality

the reduction of Transplant Related Mortality(passive) caused bythe reduction of Transplant Related Mortality

the really poor quality of life or kill youcan causethe really poor quality of life or kill you

the date of death(passive) caused bythe date of death

to significant morbidity and mortality following allogeneic hematopoietic cell transplantation ( HCTcontributingto significant morbidity and mortality following allogeneic hematopoietic cell transplantation ( HCT

to life - threatening inflammation and organ failurecan leadto life - threatening inflammation and organ failure

skin , liver , or intestinal problemscan causeskin , liver , or intestinal problems

when using these stem cells , similar to umbilical cord stem cells [ 26can be preventedwhen using these stem cells , similar to umbilical cord stem cells [ 26

morbidity and mortality in transplant recipients ( 47 , 48 , 49can causemorbidity and mortality in transplant recipients ( 47 , 48 , 49

to serious complications and in worst case deathmay leadto serious complications and in worst case death

to death in 15 % of children and at least 30 % of adults post transplantleadingto death in 15 % of children and at least 30 % of adults post transplant

to tissue damages and deathleadsto tissue damages and death

serious mortality and morbiditycausingserious mortality and morbidity

failure of donor hematopoiesis and lymphopoiesis in interferon - gamma receptor - deficient hosts Jean Sébastien Delisle Institute for Research in Immunology and Cancer , Montreal , QCcausesfailure of donor hematopoiesis and lymphopoiesis in interferon - gamma receptor - deficient hosts Jean Sébastien Delisle Institute for Research in Immunology and Cancer , Montreal , QC

skin problems such as a rash , blisters , or thickening of the skinmay causeskin problems such as a rash , blisters , or thickening of the skin

from a bone marrow transplant ( which she had as I was in my first months of cancer treatmentresultingfrom a bone marrow transplant ( which she had as I was in my first months of cancer treatment

from transplants from unrelated and human leukocyte antigen ( HLA)-mismatched related donorsresultingfrom transplants from unrelated and human leukocyte antigen ( HLA)-mismatched related donors

when the immune cells in the donor ’s stem cells attack the recipient ’s tissuesresultswhen the immune cells in the donor ’s stem cells attack the recipient ’s tissues

all sort of problemsis causingall sort of problems

problems with the eyesmay causeproblems with the eyes

broad suppression of hematopoietic primitive cells and blocks megakaryocyte differentiation in a murine modelcausesbroad suppression of hematopoietic primitive cells and blocks megakaryocyte differentiation in a murine model

broad suppression of hematopoietic primitive cells and block in megakaryocyte differentiation in a murine modelcausesbroad suppression of hematopoietic primitive cells and block in megakaryocyte differentiation in a murine model

a variety of symptoms including nausea , vomiting , diarrhea and a skin rashcan causea variety of symptoms including nausea , vomiting , diarrhea and a skin rash

the tempo of immunologic recovery after allogeneic human marrow transplantationinfluencethe tempo of immunologic recovery after allogeneic human marrow transplantation

in the rejection of tissue transplants in mismatched donorsresultedin the rejection of tissue transplants in mismatched donors

major adverse effects and ... in many cases ... deathcan causemajor adverse effects and ... in many cases ... death

from minor complications to serious events like deathresultingfrom minor complications to serious events like death

rejection of the donated bone marrow and leaves the patient vulnerable to infectioncausesrejection of the donated bone marrow and leaves the patient vulnerable to infection

an immunosuppressive state in which immune protection against infection is inadequatecreatesan immunosuppressive state in which immune protection against infection is inadequate

in the rejection of tissue transplants in HLA - mismatched donorsresultedin the rejection of tissue transplants in HLA - mismatched donors

to longer survival for stem cell transplant recipients and remove the need for potentially harmful prophylactic immune - suppressionmay leadto longer survival for stem cell transplant recipients and remove the need for potentially harmful prophylactic immune - suppression

to the adverse prognoses of treated patientscould leadto the adverse prognoses of treated patients

most non - relapse mortality ( NRMcausesmost non - relapse mortality ( NRM

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