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Smart Reasoning:

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Qaagi - Book of Why

Causes

Effects

moleculecan causeskin graft rejection

xenoreactive antibodiescauseearly graft rejection

by MHC incompatibility(passive) caused bytissue graft rejection

MHC incompatibility(passive) caused bytissue graft rejection

by MHC incompatibility.[40(passive) caused bytissue graft rejection

by MHC incompatibility [ 31(passive) caused bytissue graft rejection

the first direct demonstration ... other studiescauseaccelerated graft rejection

an immune response against the transplanted tissues ( the graft ) , which are recognized as " foreign " by T cells of the recipient ( host(passive) is caused byGraft rejection

the immune response in the transplant recipient ( host ) against the transplanted organ / tissue(passive) is caused byThe graft rejection

Otherwise , the recipient 's T cells will likely attack the transplantleadingto graft rejection

Graft - associated antigens ... antibodies or immune system cellsmay contributeto graft rejection

Differences at this region alonewould causeprompt graft rejection

the response of the host immune system against the donor cellscan leadto graft rejection

Otherwise the recipient s T cells will likely attack the transplanted organleadingto graft rejection

donor - specific anti - HLA antibodiescould causegraft rejection

Otherwise the recipients T cells will likely attack the transplanted organleadingto graft rejection

the anti - donor T cell responseleadsto graft rejection

The anti - donor activity in transplant recipients is knownto causetransplant rejection

reaction between donor and patients cellsmay causerejection of graft

14]. Graft rejection without immunosuppressionmay leadto graft rejection

by donor specific anti - HLA antibodies(passive) caused bytransplant rejection

the immune response ... self and non - self antigenscan leadto graft rejection

Sensitization to human leukocyte antigens ( HLA ) in organ transplant patientscausesgraft rejection

graft rejection ... the cellular immunitycausesgraft rejection

The development of donor specific antibodies ( DSAcan leadto graft rejection

the interactions between donor antigens and the recipient immune systemleadto graft rejection

Introduction Sensitization to HLA antigens in organ transplant patientscausesgraft rejection

organ transplant patientscausesgraft rejection

that the immune system of the human recipient attacks the transplanted organcausingtransplant rejection

a strong immune rejectionleadsto a graft rejection

The only well - described tissue - specific antigencausesgraft rejection

graft responseleadsto graft rejection

Natural killer cells in the recipientcan causegraft rejection

that failure to match for these antigensresultsin graft rejection

failure to match for these antigensresultsin graft rejection

by lymphocyte controlled immune responses in organ or tissue transplant recipients(passive) caused bygraft rejection

This process ... one mechanismcontributesto graft rejection

both cellular and humoral responses including antibodies , cytokines and cytotoxic lymphocytesleadto graft rejection

HLA antibodiesmay causegraft rejection

HLA antibodiescan causegraft rejection

to loss of the graftledto loss of the graft

to lossledto loss

in need for lifelong immunosuppressive treatmentresultsin need for lifelong immunosuppressive treatment

the ownersledthe owners

in seriouscan resultin serious

a time for him to responddid ... seta time for him to respond

from the direct response of T cells to MHC molecules , which function as histocompatibility antigensresultfrom the direct response of T cells to MHC molecules , which function as histocompatibility antigens

to graft failureleadsto graft failure

from a reaction of the patient 's immune system tothe donor tissueresultsfrom a reaction of the patient 's immune system tothe donor tissue

in deathresultedin death

The emotional pain(passive) caused byThe emotional pain

immunosuppressioncausesimmunosuppression

to chronic rejection and transplant failureleadto chronic rejection and transplant failure

to graft failurecan leadto graft failure

to the death of the patientsmight leadto the death of the patients

to transplant failureleadingto transplant failure

from the recognition of differences between graft and hostresultsfrom the recognition of differences between graft and host

the transplanted organ to failcan causethe transplanted organ to fail

a transplanted organ to failcan causea transplanted organ to fail

in lower incidences of post - operative complications in Transplant surgeryhas resultedin lower incidences of post - operative complications in Transplant surgery

to poor long - term outcomesleadingto poor long - term outcomes

in late allograft failingresultingin late allograft failing

from a bone marrow or organ transplantresultsfrom a bone marrow or organ transplant

early complications(passive) caused byearly complications

the prognosis of corneal transplantationgreatly influencesthe prognosis of corneal transplantation

to early graft damage and losscan leadto early graft damage and loss

in fibrosis or edemaresultingin fibrosis or edema

usuallydoes ... resultusually

typicallyresultedtypically

severe injurycan causesevere injury

opacity(passive) caused byopacity

from selective elimination of T regs in the same modelresultingfrom selective elimination of T regs in the same model

to novel preventionmight leadto novel prevention

in redness ... sensitivity to light and blurred visionmay resultin redness ... sensitivity to light and blurred vision

to heart failure in transplant patientsleadingto heart failure in transplant patients

from a reaction of the patient 's immune system to the donor tissueresultsfrom a reaction of the patient 's immune system to the donor tissue

to cardiaccontributingto cardiac

infrequentlyleadsinfrequently

from ABO - antigen - antibody interactions and the excellent outcomes obtained after ABO - incompatible kidney transplantationresultingfrom ABO - antigen - antibody interactions and the excellent outcomes obtained after ABO - incompatible kidney transplantation

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Smart Reasoning:

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