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Balanced vasodilation occurs via vascular PDE III inhibitionleadingto endothelial smooth muscle relaxation and calcium efflux
dependent calciumchannelscausinga reduction in intracellular calcium andvascular smooth muscle relaxation
May decrease inflammation by stabilizing leukocytic lysosomal membrane , decreasing number and activity of inflammatory cells , inhibiting bronchoconstrictionleadingto direct smooth muscle relaxation ) , and reducing airway hyperresponsiveness
muscle contractionsleadingto smooth muscle relaxation and reduced calcium
This inhibits calcium influxcausinga reduction in intracellular calcium leading to relaxation of vascular smooth muscle and vasodilatation
Inhibition of PDE5 by sildenafil leads to an increased intracellular level of cGMPresultingin a decreased intracellular concentration of calcium , smooth muscle relaxation , and vasodilatation
cyclic guanosine monophosphate ( cGMP ) , a secondary signalling moleculeleadsto decreased intracellular calcium and smooth muscle relaxation
It is a beta-2 agonistcausesrelaxation of bronchiole smooth muscle and thereofre vasodilation of airways
the vascular smooth muscle cellscausinga decrease in intracellular calcium ion concentration and vascular smooth muscle relaxation
the beneficial effect on pulmonary function.22might causethe beneficial effect on pulmonary function.22
the forming of calcium deposits randomly in your bodypreventingthe forming of calcium deposits randomly in your body
researchers to suggest it may offer therapeutic solutions for persons suffering from upper respiratory conditionsleadingresearchers to suggest it may offer therapeutic solutions for persons suffering from upper respiratory conditions
to the pathogenesis of asthmacontributeto the pathogenesis of asthma
to migraineleadsto migraine
in dramatically lowered blood pressure and feelings of warmth , flushing and light - headednessresultingin dramatically lowered blood pressure and feelings of warmth , flushing and light - headedness
to bronchodilation , improvement in Forced Expiratory Volume in 1 st second ( FEV1 ) and decrease air trapping and dynamic hyperinflationleadingto bronchodilation , improvement in Forced Expiratory Volume in 1 st second ( FEV1 ) and decrease air trapping and dynamic hyperinflation
in increased mucous production , constricting the skinresultingin increased mucous production , constricting the skin
collapse of the traumatized and already distorted airwaycan causecollapse of the traumatized and already distorted airway