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Qaagi - Book of Why

Causes

Effects

peripheral destruction or consumption of platelets with the bone marrow responding by increasing platelet production(passive) to be caused bythrombocytopenia with large platelets

gain - of - function variants in GP1BA leading to enhanced GPIbα - von Willebrand factor ( vWF ) interaction(passive) caused bylarge platelets

a defect in the nonmuscle myosin heavy chain(passive) are caused byLarge platelets

gain - of - function variants in GP1BA leading to enhanced GPIbα von Willebrand factor interaction(passive) caused bylarge platelets

Nplatecausinggiant platelets " HappyHopeful•

the cytoskeleton of megakaryocytescausesgiant platelets and thrombocytopenia

May - Hegglin anomalycausesgiant misshapen platelets

Giulio Bizzozero(passive) were discovered byL. Olcay Platelets

MYH-9 mutations(passive) caused bygiant platelets

real problems in determining the real platelet count in Cavaliers so a blood smear is really the way to goare causingreal problems in determining the real platelet count in Cavaliers so a blood smear is really the way to go

difficulties because platelet counting depends , to some extent , on particle sizecan createdifficulties because platelet counting depends , to some extent , on particle size

internal bleedingcan causeinternal bleeding

because NEW platelets are biggerare causedbecause NEW platelets are bigger

either to pulmonary hypertension or the large vessel arterial occlusion that produces stroke in some children with sickle cell diseasecontributeeither to pulmonary hypertension or the large vessel arterial occlusion that produces stroke in some children with sickle cell disease

an unaware vet to suspect anemiaCan ... causean unaware vet to suspect anemia

to better platelet recovery in patientsledto better platelet recovery in patients

in low platelet count [ 18,19may ... resultin low platelet count [ 18,19

bodypromptsbody

to a falsely low countleadingto a falsely low count

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