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diseasecausinggenetic component.[2
COL4A1 and COL4A2 mutations ( Meuwissen et al . , 2015(passive) caused bygenetic porencephaly
a particular famine ... , not to their childrencausedgenetic disruptions
the selective pressures of the climatepromptedgenetic adaptation.[57
a particular faminecausedgenetic disruptions
Another mechanismcausinggene duplication
Types of mutationcausesGene duplication
mutations(passive) caused byGene duplication
locicausinggenetic incompatibilities
certain combinationsdo ... causegenetic incompatibilities
mutationscauseduplication of genes
what Random mutationcan causeduplication of genes
the Pish locus ... DSBsmight have causedgene duplication
by increased radiation levels(passive) caused bygenetic malformations
the misrepair of chromosomal double - strand breaks ( DSBs ) , which arise spontaneously during the life of a cell(passive) is sometimes caused byGene duplication
Intraspecific variation in chromosome structuremay causegenetic incompatibilities
more likelyto causegenetic replication
Recombination ... by whichcausesgenetic mixing
shared origins(passive) caused bygenetic overlap
by between - element ( ectopic ) recombination(passive) caused bygenetic rearrangements
by ectopic recombination or the retrotransposition process(passive) caused bygenetic rearrangements
The Human Genome projectalso discoveredgenetic polymorphisms
the pieces of the pairing parternsresultinggenetic recombination
Those regionsdiscoveredgenetic polymorphisms
comprehensive oligonucleotide microarrays ... that can be usedto discovergenetic polymorphisms
some daydiscovergenetic polymorphisms
enzyme - substrate reactions , energy - producing reactions , antibody - antigen reactions , the chemical interactionsresultedin genetic duplication
Down Syndrome ... the twenty - first chromosomecausesgenetic exceptionalities
by your environment(passive) are ... influenced bygenetic predispositions
We knowcausesgenetic defects."[57
It is now possibleto discovergenetic predispositions
Concentrations of just a few parts per billion ... enoughto causegenetic rearrangement
The recognition of our lifestyle choices ( diet , toxic exposure , medications and stressto influencegenetic predispositions
external factors ... citing religious attendance as a mediating factor in political participation(passive) can be influenced bygenetic predispositions
expression and function of proteins involved in drug metabolism and transport as well as drug targets and their effector pathwaysmay also influenceexpression and function of proteins involved in drug metabolism and transport as well as drug targets and their effector pathways
to the differences in disease risks and drug responses amongst different individualsmay contributeto the differences in disease risks and drug responses amongst different individuals
to phenotypic differences amongst individuals , including disease risk and drug responsecan contributeto phenotypic differences amongst individuals , including disease risk and drug response
how well the drug will work in particular clientscould influencehow well the drug will work in particular clients
how perfectly the drug functions in specific individualscould influencehow perfectly the drug functions in specific individuals
to differences in expression and activity of enzymesmay leadto differences in expression and activity of enzymes
to interindividual variation in drug responsecontributeto interindividual variation in drug response
to the low DNA repair capacity and to the variants associated with detoxification capacity reduction , in which mutations are responsible for the increasing susceptibility to such damagesmay contributeto the low DNA repair capacity and to the variants associated with detoxification capacity reduction , in which mutations are responsible for the increasing susceptibility to such damages
to the observed variation in diseasecontributeto the observed variation in disease
how very well the drug works in specific clientsmay influencehow very well the drug works in specific clients
to differences in disease outcome.[7may contributeto differences in disease outcome.[7
the magnitude of cytokine response Genetic polymorphisms directly influence inter individual variation in the magnitude of cytokine response and contribute to an individual?s clinical outcomeinfluencethe magnitude of cytokine response Genetic polymorphisms directly influence inter individual variation in the magnitude of cytokine response and contribute to an individual?s clinical outcome
in differences in drug metabolismresultingin differences in drug metabolism
susceptibility to these and other diseaseinfluencesusceptibility to these and other disease
in susceptibility or resistance to infectioncan resultin susceptibility or resistance to infection
to altered expression and function of the protein in the placentaleadingto altered expression and function of the protein in the placenta
in altered gene expression or functional changes of the encoded moleculesmay resultin altered gene expression or functional changes of the encoded molecules
to the variability of drug effectscontributeto the variability of drug effects
in altered responsiveness in drug targets ( e.g. receptor functioncan resultin altered responsiveness in drug targets ( e.g. receptor function
to individual variation in the trait Association analysiscontributeto individual variation in the trait Association analysis
toward interindividual variations in drug responsecontributetoward interindividual variations in drug response
the risk of MM and the response to cisplatin based MM treatmentinfluencethe risk of MM and the response to cisplatin based MM treatment
to differential susceptibility to the development and progression of cancercontributingto differential susceptibility to the development and progression of cancer
drug response and its clinical applicationsinfluencingdrug response and its clinical applications
their function and hence the response to drugsinfluencetheir function and hence the response to drugs
to changes in the expression , activity or selectivity of the enzymeleadingto changes in the expression , activity or selectivity of the enzyme
the expression and/or activity of CYP2D6 ... and inter - individual differences in drug activation and elimination caused by CYP2D6influencethe expression and/or activity of CYP2D6 ... and inter - individual differences in drug activation and elimination caused by CYP2D6
reduced receptor expression or signalingcausereduced receptor expression or signaling
to the risk of M - AS in this populationcontributeto the risk of M - AS in this population
phenotypic variation in this processcan causephenotypic variation in this process
in increased prostate cancer riskresultingin increased prostate cancer risk
to the individual susceptibilitycontributingto the individual susceptibility
individual susceptibilitymay influenceindividual susceptibility
drug responseinfluencingdrug response
drug responsecan influencedrug response
in susceptibility or resistancecan resultin susceptibility or resistance
survival in ovarian cancer patients by affecting how well the patient responds to treatmentcan influencesurvival in ovarian cancer patients by affecting how well the patient responds to treatment
gene functioncan influencegene function
in DECREASED activity of this enzymeresultin DECREASED activity of this enzyme
disease severityalso influencedisease severity