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Qaagi - Book of Why

Causes

Effects

by genetic drift(passive) caused byGenetic risk differentiation

the Alpscausedthe great genetic differentiation

Isolation and recolonization driven by glacial events have also been suggestedto influencegenetic population differentiation

map regionscontributinggenetic differentiation among the subpopulations

the timing of speciationinfluencespatterns of genetic differentiation

the mechanismscausinggenetic differentiation of populations

from the environmental and the genetic effects(passive) is resultedGenetic differentiation of populations

cellular stresscausinggenetic pathogenesis

the mechanismscauseinterpopulational genetic differentiation

the evolutionary mechanisms ( e.g. selection versus limited gene flowcausinggenetic differentiation

by genetic drift within population(passive) was caused bygenetic differentiation

gene flow between these populations is much reducedleadingto genetic differentiation

Local genetic drift is knownto influencegenetic differentiation

genetic drift or selection(passive) may be caused bygenetic differentiation

Geographical isolation , as well as artificial breeding and selectionmight have likely causedthe genetic differentiation

Habitat fragmentation and gene flowmay resultin genetic differentiation

by drift between two populations(passive) caused bythe genetic differentiation

Gene flow andresultedgenetic differentiation

gene flowmay leadto genetic differentiation

by selection for different adaptation(passive) caused bygenetic differentiation

The geographic distance between populations was foundto be contributingto the genetic differentiation

by genetic drift(passive) caused bygenetic differentiation

the genetic driftwould ... causethe genetic differentiation

genetic drift(passive) caused bythe genetic differentiation

genetic driftleadingto genetic differentiation

by genetic drift.(4(passive) caused bygenetic differentiation

by selection for adaptation and use(passive) caused bygenetic differentiation

several processescan causegenetic differentiation

the evolutionary mechanismscausinggenetic differentiation

the factorsinfluencinggenetic differentiation

by natural selection being confounded with genetic drift in subdivided populations(passive) caused bygenetic differentiation

natural selection being confounded with genetic drift in subdivided populations(passive) caused bygenetic differentiation

by selection for adaptation and use , Theoretical and Applied Genetics 100(2(passive) caused bygenetic differentiation

post - introduction selectionleadingto genetic differentiation

by migration and/or selection(passive) may have been influenced bygenetic differentiation

by migration and/or selection(passive) may have been influencedgenetic differentiation

by selection for adaptation and(passive) caused bygenetic differentiation

the colonization of new islands ... the source populationsmay resultin genetic differentiation

both geographic and environmental heterogeneitycontributeto genetic differentiation

stepwise - like mutationscontributedto genetic differentiation

from different selective pressures that shaped the 4 cohorts during their juvenile phaseto resultfrom different selective pressures that shaped the 4 cohorts during their juvenile phase

to the innate survival capabilities for each plantmay be contributingto the innate survival capabilities for each plant

to speciation 52leadsto speciation 52

to their transcriptional repressionleadingto their transcriptional repression

to variation in quantitative traits , such as blood pressure ) in experimental crosses ( such as in micecontributeto variation in quantitative traits , such as blood pressure ) in experimental crosses ( such as in mice

expression and function of proteins involved in drug metabolism and transport as well as drug targets and their effector pathwaysmay also influenceexpression and function of proteins involved in drug metabolism and transport as well as drug targets and their effector pathways

to the differences in disease risks and drug responses amongst different individualsmay contributeto the differences in disease risks and drug responses amongst different individuals

in other genetic aberrationresultingin other genetic aberration

to phenotypic differences amongst individuals , including disease risk and drug responsecan contributeto phenotypic differences amongst individuals , including disease risk and drug response

of nucleic acidcomposedof nucleic acid

to differences in expression and activity of enzymesmay leadto differences in expression and activity of enzymes

to interindividual variation in drug responsecontributeto interindividual variation in drug response

to the low DNA repair capacity and to the variants associated with detoxification capacity reduction , in which mutations are responsible for the increasing susceptibility to such damagesmay contributeto the low DNA repair capacity and to the variants associated with detoxification capacity reduction , in which mutations are responsible for the increasing susceptibility to such damages

to the observed variation in diseasecontributeto the observed variation in disease

to common complex diseasescontributingto common complex diseases

to differences in disease outcome.[7may contributeto differences in disease outcome.[7

complex traitsinfluencecomplex traits

the magnitude of cytokine response Genetic polymorphisms directly influence inter individual variation in the magnitude of cytokine response and contribute to an individual?s clinical outcomeinfluencethe magnitude of cytokine response Genetic polymorphisms directly influence inter individual variation in the magnitude of cytokine response and contribute to an individual?s clinical outcome

in differences in drug metabolismresultingin differences in drug metabolism

susceptibility to these and other diseaseinfluencesusceptibility to these and other disease

in susceptibility or resistance to infectioncan resultin susceptibility or resistance to infection

to altered expression and function of the protein in the placentaleadingto altered expression and function of the protein in the placenta

to trait variationcontributeto trait variation

to phenotypic variation based on linkage disequilibriumcontributeto phenotypic variation based on linkage disequilibrium

in altered gene expression or functional changes of the encoded moleculesmay resultin altered gene expression or functional changes of the encoded molecules

to the variability of drug effectscontributeto the variability of drug effects

in altered responsiveness in drug targets ( e.g. receptor functioncan resultin altered responsiveness in drug targets ( e.g. receptor function

to individual variation in the trait Association analysiscontributeto individual variation in the trait Association analysis

toward interindividual variations in drug responsecontributetoward interindividual variations in drug response

the risk of MM and the response to cisplatin based MM treatmentinfluencethe risk of MM and the response to cisplatin based MM treatment

to differential susceptibility to the development and progression of cancercontributingto differential susceptibility to the development and progression of cancer

drug response and its clinical applicationsinfluencingdrug response and its clinical applications

to changes in the expression , activity or selectivity of the enzymeleadingto changes in the expression , activity or selectivity of the enzyme

the expression and/or activity of CYP2D6 ... and inter - individual differences in drug activation and elimination caused by CYP2D6influencethe expression and/or activity of CYP2D6 ... and inter - individual differences in drug activation and elimination caused by CYP2D6

reduced receptor expression or signalingcausereduced receptor expression or signaling

phenotypic variation in this processcan causephenotypic variation in this process

in increased prostate cancer riskresultingin increased prostate cancer risk

quantitative traitsinfluencequantitative traits

these traits and underlying candidate genes and networksinfluencingthese traits and underlying candidate genes and networks

to the individual susceptibilitycontributingto the individual susceptibility

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