by genetic drift.(4(passive) caused bygenetic differentiation
by selection for adaptation and use(passive) caused bygenetic differentiation
several processescan causegenetic differentiation
the evolutionary mechanismscausinggenetic differentiation
the factorsinfluencinggenetic differentiation
by natural selection being confounded with genetic drift in subdivided populations(passive) caused bygenetic differentiation
natural selection being confounded with genetic drift in subdivided populations(passive) caused bygenetic differentiation
by selection for adaptation and use , Theoretical and Applied Genetics 100(2(passive) caused bygenetic differentiation
post - introduction selectionleadingto genetic differentiation
by migration and/or selection(passive) may have been influenced bygenetic differentiation
by migration and/or selection(passive) may have been influencedgenetic differentiation
by selection for adaptation and(passive) caused bygenetic differentiation
the colonization of new islands ... the source populationsmay resultin genetic differentiation
both geographic and environmental heterogeneitycontributeto genetic differentiation
stepwise - like mutationscontributedto genetic differentiation
from different selective pressures that shaped the 4 cohorts during their juvenile phaseto resultfrom different selective pressures that shaped the 4 cohorts during their juvenile phase
to the innate survival capabilities for each plantmay be contributingto the innate survival capabilities for each plant
to speciation 52leadsto speciation 52
to their transcriptional repressionleadingto their transcriptional repression
to variation in quantitative traits , such as blood pressure ) in experimental crosses ( such as in micecontributeto variation in quantitative traits , such as blood pressure ) in experimental crosses ( such as in mice
expression and function of proteins involved in drug metabolism and transport as well as drug targets and their effector pathwaysmay also influenceexpression and function of proteins involved in drug metabolism and transport as well as drug targets and their effector pathways
to the differences in disease risks and drug responses amongst different individualsmay contributeto the differences in disease risks and drug responses amongst different individuals
in other genetic aberrationresultingin other genetic aberration
to phenotypic differences amongst individuals , including disease risk and drug responsecan contributeto phenotypic differences amongst individuals , including disease risk and drug response
of nucleic acidcomposedof nucleic acid
to differences in expression and activity of enzymesmay leadto differences in expression and activity of enzymes
to interindividual variation in drug responsecontributeto interindividual variation in drug response
to the low DNA repair capacity and to the variants associated with detoxification capacity reduction , in which mutations are responsible for the increasing susceptibility to such damagesmay contributeto the low DNA repair capacity and to the variants associated with detoxification capacity reduction , in which mutations are responsible for the increasing susceptibility to such damages
to the observed variation in diseasecontributeto the observed variation in disease
to common complex diseasescontributingto common complex diseases
to differences in disease outcome.[7may contributeto differences in disease outcome.[7
complex traitsinfluencecomplex traits
the magnitude of cytokine response Genetic polymorphisms directly influence inter individual variation in the magnitude of cytokine response and contribute to an individual?s clinical outcomeinfluencethe magnitude of cytokine response Genetic polymorphisms directly influence inter individual variation in the magnitude of cytokine response and contribute to an individual?s clinical outcome
in differences in drug metabolismresultingin differences in drug metabolism
susceptibility to these and other diseaseinfluencesusceptibility to these and other disease
in susceptibility or resistance to infectioncan resultin susceptibility or resistance to infection
to altered expression and function of the protein in the placentaleadingto altered expression and function of the protein in the placenta
to trait variationcontributeto trait variation
to phenotypic variation based on linkage disequilibriumcontributeto phenotypic variation based on linkage disequilibrium
in altered gene expression or functional changes of the encoded moleculesmay resultin altered gene expression or functional changes of the encoded molecules
to the variability of drug effectscontributeto the variability of drug effects
in altered responsiveness in drug targets ( e.g. receptor functioncan resultin altered responsiveness in drug targets ( e.g. receptor function
to individual variation in the trait Association analysiscontributeto individual variation in the trait Association analysis
toward interindividual variations in drug responsecontributetoward interindividual variations in drug response
the risk of MM and the response to cisplatin based MM treatmentinfluencethe risk of MM and the response to cisplatin based MM treatment
to differential susceptibility to the development and progression of cancercontributingto differential susceptibility to the development and progression of cancer
drug response and its clinical applicationsinfluencingdrug response and its clinical applications
to changes in the expression , activity or selectivity of the enzymeleadingto changes in the expression , activity or selectivity of the enzyme
the expression and/or activity of CYP2D6 ... and inter - individual differences in drug activation and elimination caused by CYP2D6influencethe expression and/or activity of CYP2D6 ... and inter - individual differences in drug activation and elimination caused by CYP2D6
reduced receptor expression or signalingcausereduced receptor expression or signaling
phenotypic variation in this processcan causephenotypic variation in this process
in increased prostate cancer riskresultingin increased prostate cancer risk
quantitative traitsinfluencequantitative traits
these traits and underlying candidate genes and networksinfluencingthese traits and underlying candidate genes and networks
to the individual susceptibilitycontributingto the individual susceptibility