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Qaagi - Book of Why

Causes

Effects

Both pleiotropy and linkage disequilibriumcreategenetic correlations between traits

linkage and pleiotropycontributeto the genetic correlation between quantitative traits

Inferred QTL often affected more than one traitcontributingto the genetic correlation between those traits

selection on phenotypic plasticitycould resultin genetic correlations among the traits

maintain linkage disequilibriaresultingin genetic correlations between traits

indirect effects(passive) is ... caused bythe genetic correlation among the traits

effects of a polymorphism directly influencing both traits or linkage disequilibrium between responsible polymorphisms(passive) would be generally caused byGenetic correlation

among - environment heteroscedasticity(passive) caused bygenetic correlation

in differentiation with respect to traits that are not related to fitness if there is sufficient indirect selection ( Darwin 1859 , Gould and Lewontin 1979 , Lande and Arnold 1983can resultin differentiation with respect to traits that are not related to fitness if there is sufficient indirect selection ( Darwin 1859 , Gould and Lewontin 1979 , Lande and Arnold 1983

tradeoff by with time and luck genetic architecture can evolve too  Gene flowcreatetradeoff by with time and luck genetic architecture can evolve too  Gene flow

from either pleiotropic or tightly - linked QTLstypically resultfrom either pleiotropic or tightly - linked QTLs

from linkage between the loci that affect themcan resultfrom linkage between the loci that affect them

in a correlated response to selectionwill resultin a correlated response to selection

the focal trait(passive) caused bythe focal trait

correlated responses to selectionmay causecorrelated responses to selection

to increased risk for both disordersleadto increased risk for both disorders

constraints(passive) caused byconstraints

rapid adaptation to new environmentsinfluencedrapid adaptation to new environments

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