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Qaagi - Book of Why

Causes

Effects

unequal crossing - over or gene conversion(passive) caused bygene duplication

Even mutationscauseduplication of a gene

54 Paralogous genesresultfrom gene duplication

unequal crossover and retroposition , respectively(passive) caused bygene duplication rates

The transcriptional changes affecting one or both of the gene copiesresultingfrom gene duplication

o Chromosome - level mutations can causegene duplication

Unequal crossing - over between two chromosomes carrying the HBA*3 alleleoriginatedthe HBA1–HBA2 gene duplication

Origin and Evolution of Redundant Genes Gene redundancymost often resultsfrom Gene duplication

Pearson Benjamin Cummings Paralogous genesresultfrom gene duplication

Pearson Benjamin Cummings 63 Paralogous genesresultfrom gene duplication

Concatenation of globin domainsresultingfrom gene duplication

two genesresultingfrom gene duplication

a genotype ... genesoriginatesfrom gene duplication

The AHL genesare resultedfrom gene duplication

If a random mutation wereto causea gene duplication

MiscellaneousIt ... thoughtto resultfrom gene duplication

MiscellaneousiMiscellaneousIt ... thoughtto resultfrom gene duplication

Homologs ... paralogs ,originatefrom gene duplication

Functional redundancyresultingfrom gene duplication

igf2 genes ... zebrafishresultedfrom gene duplication

New functional genesresultingfrom gene duplication

2 Consequences of mutationcausesGene duplication

The PHO3 gene ... thoughtto resultfrom gene duplication

The PHO1 gene ... thoughtto resultfrom gene duplication

Gene Duplication & Families Homologyresultingfrom gene duplication

| Orthologous genes : homologous gene that is found in different species due to speciation | Paralogous genesresultfrom gene duplication

evidence that these Brachypodium COMT genes are likely to be paralogs of BdCOMT4resultedfrom gene duplication

The large number of CmaGST genesresultedfrom gene duplication

multiple nifDK - like genesmay resultfrom gene duplication

the various lipase encoding geneshave ... resultedfrom gene duplication

mg preis genes ... zebrafishresultedfrom gene duplication

which further suggests clustering of cadherin genesoriginating probablyfrom gene duplication

the cytidine deaminase gene family ... one of seven related genes or pseudogenes found in a cluster thoughtto resultfrom gene duplication

The REIL1 and the REIL2 paralogs of A. thalianaoriginatedfrom gene duplication

The higher gene expressionresultingfrom gene duplication

These paralog genes ... Additional file 4resultedfrom gene duplication

the two tlc genes found in Chlamydiaceaeresultedfrom gene duplication

whereas mice have 34 NLRs genesoriginatingfrom gene duplication

the cytidine deaminase gene family ... thoughtto resultfrom gene duplication

multiple nifH - like and nifDK - like genesmay resultfrom gene duplication

to these two paralogsleadingto these two paralogs

to the generation of these paralogsleadto the generation of these paralogs

to oligomeric paralogsmay leadto oligomeric paralogs

in chloroplast paralogsresultingin chloroplast paralogs

to the establishment [ of these ] paralogsleadingto the establishment [ of these ] paralogs

likely represent paralogs(passive) originated bylikely represent paralogs

initially redundant paralogscreatesinitially redundant paralogs

to multiple SERCA paralogsleadingto multiple SERCA paralogs

to new genes [ 1,2could leadto new genes [ 1,2

to new genes among eukaryoteshas ledto new genes among eukaryotes

in two similar segments homologous with the subunit of dimeric human glyoxalase I. Biochem J , 316 , 1005–1006.OpenUrlFREEresultingin two similar segments homologous with the subunit of dimeric human glyoxalase I. Biochem J , 316 , 1005–1006.OpenUrlFREE

2.Paralogous genes(passive) created by2.Paralogous genes

to families of paralogous geneshas ledto families of paralogous genes

to the closely related MPP paralogsleadingto the closely related MPP paralogs

in two identical paralogs that diverge through mutationresultsin two identical paralogs that diverge through mutation

homologous genes(passive) originated byhomologous genes

that the respective genes(passive) originated bythat the respective genes

to two paralogous genes with compensatory functionleadingto two paralogous genes with compensatory function

in different numbers of paralogs in different taxaresultedin different numbers of paralogs in different taxa

telomere protein paralogs with novel functions33has createdtelomere protein paralogs with novel functions33

2 or more paralogs within the genome of a single organismcan lead2 or more paralogs within the genome of a single organism

many genes in tandemto createmany genes in tandem

genes with more complex functionscan creategenes with more complex functions

in A - type and S - type genesresultingin A - type and S - type genes

to new functional genesmight leadto new functional genes

to specialized gamma - aminobutyrate and beta - alanine aminotransferase in yeast FEBSledto specialized gamma - aminobutyrate and beta - alanine aminotransferase in yeast FEBS

in Evolution of LWS and SWS2 Pigment GenesResultedin Evolution of LWS and SWS2 Pigment Genes

to evolution of multigene familiesleadsto evolution of multigene families

in different selective pressures on the two genescan resultin different selective pressures on the two genes

a second copy of a gene ( paralogcan createa second copy of a gene ( paralog

two copies of a particular gene , giving rise to two or more genes with similar sequence and often similar function known as paralogsmay causetwo copies of a particular gene , giving rise to two or more genes with similar sequence and often similar function known as paralogs

to individuals with two copies of a gene where in their ancestors there was only oneoccasionally leadsto individuals with two copies of a gene where in their ancestors there was only one

new genes allowing some of those new copies to continue mutating for new functions:"Wecreatesnew genes allowing some of those new copies to continue mutating for new functions:"We

to novel genes in a species , which could contribute to the rapid emergence of human - specific traits , like the increased size of the brain ’s cortexcan leadto novel genes in a species , which could contribute to the rapid emergence of human - specific traits , like the increased size of the brain ’s cortex

a selective conflict between the paralogs , which appear to have driven the evolution of a novel protein function.pH Gradient in Light of Electroneutrality CREDIThas createda selective conflict between the paralogs , which appear to have driven the evolution of a novel protein function.pH Gradient in Light of Electroneutrality CREDIT

to rom-1 and rds - like genesleadingto rom-1 and rds - like genes

in relaxed selective constraints in duplicated genescan also resultin relaxed selective constraints in duplicated genes

orthologs ( genes and their products in different species that evolved from a common ancestral gene by speciation ) and paralogs ( genes and their products(passive) originated byorthologs ( genes and their products in different species that evolved from a common ancestral gene by speciation ) and paralogs ( genes and their products

in extra copies of existing genesresultsin extra copies of existing genes

in high diversification of Class I genesresultedin high diversification of Class I genes

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