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Clavis Pharma to improve treatment outcomes in patients with pancreatic and other solid tumours Clavis Pharma to receive up to $ 380 million in staged payments , including a $ 15 million signing fee(passive) designed bygemcitabine
Galunisertib +resultedgemcitabine
These peoplediscoveredgemcitabine
to mimic the structure of cytidine , one of the bases that make up DNA(passive) is designedGemcitabine
to treat multiple cancers individually or while combined with other chemotherapeutic drugs(passive) is designedGemcitabine
to disrupt the growth of cancer cells , which may cause them to die and prevent further growth of cancer cells(passive) is designedGemcitabine
to block the growth of cancer cells , which may cause cancer cells to die(passive) is designedGemcitabine
to disrupt the growth of cancer cells , which may cause cancer cells to die(passive) is designedGemcitabine
Combination of ABC294640 withresultedgemcitabine
to disrupt the growth of the cancer cells , which causes the cancer cells to start to die(passive) is designedGemcitabine
to target and kill cancer cells by inserting itself into the DNA of a pancreatic cancer cell(passive) is designedGemcitabine
Larry Hertel , who was working for the Lilly Research Laboratory of Eli Lilly and Company in Indianapolis(passive) was first discovered byGemcitabine
the tumor cell death(passive) caused bythe tumor cell death
the cell death program(passive) triggered bythe cell death program
Demedts M. Hemolytic - uremic syndrome(passive) caused byDemedts M. Hemolytic - uremic syndrome
a variety of side effectscan causea variety of side effects
birth defects and fetal death in animalscan causebirth defects and fetal death in animals
fewer side effects than mitomycinmay causefewer side effects than mitomycin
in enhanced cell death with respect to the sole gemcitabine treatmentresultedin enhanced cell death with respect to the sole gemcitabine treatment
quite bad side effects ... and which was not effectivecausedquite bad side effects ... and which was not effective
in marked apoptotic and necrotic cell death in PANC-1 cellsresultedin marked apoptotic and necrotic cell death in PANC-1 cells
changes to the lungscan causechanges to the lungs
a pro - survival response in pancreatic cancer cellstriggersa pro - survival response in pancreatic cancer cells
cancer cells replicating themselvespreventscancer cells replicating themselves
a high incidence of non - haematological toxicities with a maximum tolerated dose of only 10mgm2.andcauseda high incidence of non - haematological toxicities with a maximum tolerated dose of only 10mgm2.and
minimal modulation of carboplatin - DNA monoadduct formation and repair in bladder cancer cells ' , Chemical Research in Toxicologycausesminimal modulation of carboplatin - DNA monoadduct formation and repair in bladder cancer cells ' , Chemical Research in Toxicology
angiogenesis - promoting molecular signals in pancreatic cancer cellstriggersangiogenesis - promoting molecular signals in pancreatic cancer cells
fetal harm when administered to a pregnant womancan causefetal harm when administered to a pregnant woman
minimal modulation of carboplatin - DNA monoadduct formation and repair in bladder cancer cells — UC Davis Sisi Wang , Hongyong Zhang , Michael Malfatti , Ralph Wcausesminimal modulation of carboplatin - DNA monoadduct formation and repair in bladder cancer cells — UC Davis Sisi Wang , Hongyong Zhang , Michael Malfatti , Ralph W
reversible hypospermatogenesis in male micecausedreversible hypospermatogenesis in male mice
TMA with characteristics that mimic the hemolytic - uremic syndrome with microangiopathic hemolytic anemia , mild thrombocytopenia , and severe acute kidney injury ( AKIcan ... causeTMA with characteristics that mimic the hemolytic - uremic syndrome with microangiopathic hemolytic anemia , mild thrombocytopenia , and severe acute kidney injury ( AKI
problems with the production of DNA and RNA in the cancer cellscausesproblems with the production of DNA and RNA in the cancer cells
side effects including a low white blood cell count , which increases susceptibility to infectionscan causeside effects including a low white blood cell count , which increases susceptibility to infections
side effects ... e.g. subfebrile body temperature , fatigue , myalgia , arthralgia , or paraesthesiamay causeside effects ... e.g. subfebrile body temperature , fatigue , myalgia , arthralgia , or paraesthesia
tumour cells(passive) caused bytumour cells
to a radiosensitising effect in both monolayer and spheroid glioblastoma cultures [ 15can leadto a radiosensitising effect in both monolayer and spheroid glioblastoma cultures [ 15
side effects , such as lower levels of infection - fighting blood cells , swelling in the legs and arms , rash , flu - like symptoms , nausea , and — rarely — vomitingdid causeside effects , such as lower levels of infection - fighting blood cells , swelling in the legs and arms , rash , flu - like symptoms , nausea , and — rarely — vomiting
pancreatic cancer behavior via the upregulation of sCLU , which might play a major role in the effects of gemcitabine , protecting pancreatic cancer cells from the effects of gemcitabinemay influencepancreatic cancer behavior via the upregulation of sCLU , which might play a major role in the effects of gemcitabine , protecting pancreatic cancer cells from the effects of gemcitabine
pancreatic cancer behavior by means of the upregulation of sCLU , which may perform a major position during the results of gemcitabine , protecting pancreatic cancer cells through the effects of gemcitabinemay ... influencepancreatic cancer behavior by means of the upregulation of sCLU , which may perform a major position during the results of gemcitabine , protecting pancreatic cancer cells through the effects of gemcitabine
pancreatic cancer conduct through the upregulation of sCLU ... which could possibly play a serious part during the effects of gemcitabine , defending pancreatic cancer cells from the effects of gemcitabinemay ... influencepancreatic cancer conduct through the upregulation of sCLU ... which could possibly play a serious part during the effects of gemcitabine , defending pancreatic cancer cells from the effects of gemcitabine
pancreatic cancer conduct by means of the upregulation of sCLU , which might play a serious role from the effects of gemcitabine , defending pancreatic cancer cells from the results of gemcitabinecould influencepancreatic cancer conduct by means of the upregulation of sCLU , which might play a serious role from the effects of gemcitabine , defending pancreatic cancer cells from the results of gemcitabine
DNA double strand breaks ( DSB ) as a result of replication fork collapse in the S - phase of the cell cycle in p53-mutated cells or induces apoptosis through PUMA ( 39 ) and Bax ( 40 ) mediated cell death programs in G1 in p53 WT cellscausesDNA double strand breaks ( DSB ) as a result of replication fork collapse in the S - phase of the cell cycle in p53-mutated cells or induces apoptosis through PUMA ( 39 ) and Bax ( 40 ) mediated cell death programs in G1 in p53 WT cells
fever , skin rash , nausea , vomiting , diarrhea , hair loss , mouth ulcers and difficulty in breathingmay causefever , skin rash , nausea , vomiting , diarrhea , hair loss , mouth ulcers and difficulty in breathing
minimal modulation of carboplatin - DNA monoadduct formation and repair in bladder cancer cells , Chemical Research in Toxicology 23 , 1653 , http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987236/pdf/nihms249068.pdf Sporty , J.L. , Kabir , M.M. , Turteltaub , K.W. , Ognibene , T. , Lin , S.J. , and Bench , G. ( 2008causesminimal modulation of carboplatin - DNA monoadduct formation and repair in bladder cancer cells , Chemical Research in Toxicology 23 , 1653 , http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987236/pdf/nihms249068.pdf Sporty , J.L. , Kabir , M.M. , Turteltaub , K.W. , Ognibene , T. , Lin , S.J. , and Bench , G. ( 2008
pancreatic cancer habits by means of the upregulation of sCLU , which could possibly play a major function within the results of gemcitabine , safeguarding pancreatic cancer cells through the results of gemcitabinemay influencepancreatic cancer habits by means of the upregulation of sCLU , which could possibly play a major function within the results of gemcitabine , safeguarding pancreatic cancer cells through the results of gemcitabine
DNA damage such as double stand breaks in cells , followed rapidly by histone H2AX phosphorylation ( 𝛄H2AX ) , with foci observed within the first minutecan createDNA damage such as double stand breaks in cells , followed rapidly by histone H2AX phosphorylation ( 𝛄H2AX ) , with foci observed within the first minute
the production of certain kinds of killer T - cells that could help in the attack on cancer cellstriggersthe production of certain kinds of killer T - cells that could help in the attack on cancer cells
anemia that was immensly improvedcausedanemia that was immensly improved
The active surveillance of anemia(passive) caused byThe active surveillance of anemia
a low - grade fevercan causea low - grade fever
rashes , oedema , haematuria , flu - like symptoms , nausea and vomitingcan causerashes , oedema , haematuria , flu - like symptoms , nausea and vomiting
birth defects if either the male or female is using it at the time of conceptionmay causebirth defects if either the male or female is using it at the time of conception