bleeding episodesresultingfrom coagulation factor deficiencies without inhibitors to factor VIII or factor IX

Mutations in the MCFD2 genemay causeFactor V and Factor VIII combined deficiency

MCFD2 ... the second geneleadsto combined deficiency of factor V - factor VIII

The product ... since its structure is distinct from that of factor VIII , it is not expectedto leadto the formation of inhibitors against factor VIII

genetic factorscontributeto the development of inhibitors to factor VIII

As it is distinct in structure from factor VIII , it is not expectedto leadto the formation of inhibitors against factor VIII

manyleadingto treatment and factor VIII inhibitors

ACE910 ... as it is distinct in structure from factor VIII , it is not expectedto leadto the formation of inhibitors against factor VIII

The absence of von Willebrand factorcausesfactor VIII to be less stable

Blood typeinfluencesa clotting factor called Factor VIII

mutations in the F7 gene knownto causeFactor VII disorder

Genentech 's synthetic " bispecific " antibodydesignedto bypass factor VIII inhibitor in hemophilic boys

a genetic mutation in factor VII production resulting in reduced factor VII activity(passive) is caused byFactor VIII deficiency

a genetic mutation in factor VII production resulting in reduced factor VII activity(passive) is caused by Factor VIII deficiency

Factorsinfluencingfactor VIII activity

a problem with factor VII(passive) is caused byFactor VII deficiency

novel mutation mechanismsleadingto factor VIII deficiency

by an inhibitory antibody to factor viii(passive) caused byfactor viii deficiency

any drugcausingFACTOR VIII DEFICIENCY

other drugscauseFACTOR VIII DEFICIENCY

any drugcausingFACTOR VIII INHIBITION

other drugscauseFACTOR VIII INHIBITION

mutationscausingfactor VIII assay

by metal - induced oxidation(passive) is causedFactor VIII inactivation

by metal - induced oxidation(passive) is caused byFactor VIII inactivation

a specific antibodywas designedto detect factor VIII

Interindividual variation of other factorsmay ... contributee.g. , factor VIII

peoplecontributingfactor inhibitors

a true decreaseresultingfrom a factor VIII inhibitor

to the average concentration of the measured factors(passive) was setFactor IX

a defective geneleadingto factor VIII

first(passive) was ... discoveredFactor VIII

makingwas discoveredfactor VIII

in a young female patient(passive) was discoveredFactor VII

by F9(passive) caused byfactor IX

in 1952(passive) was discoveredFactor IX

of four discrete domains : a gamma - carboxyglutamic acid ( Gla)-containing domain , two epidermal growth factor ( EGF)-like domains , and a serine protease domain(passive) is composedFactor VII