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Qaagi - Book of Why

Causes

Effects

So this is our first objectiveto discovercompounds that repress DUX4 protein production in human FSHD - affected skeletal muscle

of long(passive) is composed1 Structure of Skeletal Muscle Skeletal muscle ... impaired performance of multiplication procedures

evidence ... factors associated with substrate availability and/or cellular metabolic recovery ( eg , muscle glycogen restorationinfluencethe transcriptional regulation of metabolic genes in skeletal muscle of humans during recovery from exercise

factors associated with substrate availability and/or cellular metabolic recovery ( eg , muscle glycogen restorationinfluencethe transcriptional regulation of metabolic genes in skeletal muscle of humans during recovery from exercise

studiesdesignedto test the effect of interventions on skeletal muscle function

the cellular environmentcan resultin skeletal muscle dysfunction independent of reduced mitochondrial capacity

Does heatcontributeto the exercise - induced production of HSPs in human skeletal muscle

These drugscausean uncontrolled increase in metabolism in skeletal ( voluntary ) muscles

treatment with vitamin Dmay resultin sustained increases in VDR in human skeletal muscle cells

In 1965 Holloszy showed for the first time that exercise training in rodentsresultedin a doubling of skeletal muscle mitochondria , ushering in a very active era of skeletal muscle plasticity research

reduced muscle plasticityresultingin impaired skeletal muscle adaptations to exercise - induced anabolic stimulation

a condition ... , leading to kidney failureresultseffect in the breakdown of skeletal muscle tissue

a conditionresultsin the breakdown of skeletal muscle weight tissue

exercise for 24 hours before the scanresultsin increased uptake in the skeletal muscles ( i.e. altered biodistribution

- alpha receptorsto causevasoconstriction in skeletal muscle sympathetic stimulation acts on

that deficiency in UCP3resultedin a metabolic shift in skeletal muscles that favored glycolytic metabolism

the inhibition of MSTNmay contributeto improvements in T1DM - induced skeletal muscle atrophy

- alpha receptorsto causevasoconstriction in skeletal muscle sympathetic stimulation

heat acclimation(passive) is influenced bySkeletal muscle metabolism during exercise

Exercise training ... identification of molecular mechanismscausemetabolic - related changes in human skeletal muscle

Mitochondrial Myopathy , Encephalopathy , Lactic Acidosis , and Stroke - like syndrome ( MELAS ... a mutation in mitochondrial DNAleadsto impaired oxidative metabolism in skeletal muscle

Activation of the classical renin - angiotensin system ( RAScausesdeleterious effects in skeletal muscle , including muscle wasting

Vitamin D deficiencycan causesub - optimal skeletal muscle function impacting athletic performance

In the past decade , dietary n-3 PUFAs has been demonstratedto influenceenergy metabolism in skeletal muscle , in part by acting on PPARs

A notable cause of sarcopenia is the myogenic - to - fibrogenic transdifferentiation of satellite cells by excessive upregulation of Wnt signaling with agingresultingin the impaired regenerative capacity of aged skeletal muscle

myofiber diameterscan resultin perturbations of skeletal muscle function

metabolism in other organsto influencemetabolism in other organs

the anabolic response of muscle to this form of exercisemay ... influencethe anabolic response of muscle to this form of exercise

The lack of increase in the H - reflex from passive to active shortening(passive) may thus be caused byThe lack of increase in the H - reflex from passive to active shortening

AVM with sarcolemmal features , muscle weakness and lysosomal storage diseasecauseAVM with sarcolemmal features , muscle weakness and lysosomal storage disease

dilation of arterioles and increase in flowcausedilation of arterioles and increase in flow

in oxidative stresssubsequently resultingin oxidative stress

in the development of insulin resistancemay contributein the development of insulin resistance

microtears of the myofibrils ... resulting in muscle soreness and swelling ... and decreased forced productioncausesmicrotears of the myofibrils ... resulting in muscle soreness and swelling ... and decreased forced production

microtears of the myofibrils ... resulting in muscle soreness and swellingcausesmicrotears of the myofibrils ... resulting in muscle soreness and swelling

to improved manifestation of MMPs ( Carmeli et al . , 2005leadsto improved manifestation of MMPs ( Carmeli et al . , 2005

in muscle hypertrophy and improved muscle histology and physiology in Dmdmdx miceresultedin muscle hypertrophy and improved muscle histology and physiology in Dmdmdx mice

expression(passive) is influenced byexpression

mRNA expression(passive) is influenced bymRNA expression

mRNA expression(passive) is influencedmRNA expression

in a smaller amplitude of the vertical oscillation of the centre of mass ... with a lower upward acceleration and a reduced duration of the aerial phaseresultsin a smaller amplitude of the vertical oscillation of the centre of mass ... with a lower upward acceleration and a reduced duration of the aerial phase

to reduced glycogen synthesis as well as impaired glucose transport and phosphorylationleadingto reduced glycogen synthesis as well as impaired glucose transport and phosphorylation

PGC-1alpha mRNA expression(passive) is influenced byPGC-1alpha mRNA expression

from resistanceresultedfrom resistance

to the prevention of type 2 diabetesleadto the prevention of type 2 diabetes

in double - muscle phenotype ( Lee and Mcpherron , 2001could resultin double - muscle phenotype ( Lee and Mcpherron , 2001

to the syndromecan leadto the syndrome

symptoms such ascausessymptoms such as

the fibrecauses contractionofthe fibre

alsomay ... contributealso

to the pathogenesis of insulin resistancecontributesto the pathogenesis of insulin resistance

to impaired insulin - stimulated PKB / Akt ( Ser473 ) phosphorylation and reduced insulin - stimulated glucose uptake ... thus interfering with the signal transduction mechanisms involved in insulin actionsleadsto impaired insulin - stimulated PKB / Akt ( Ser473 ) phosphorylation and reduced insulin - stimulated glucose uptake ... thus interfering with the signal transduction mechanisms involved in insulin actions

in inhibition of insulin - mediated glucose uptake and insulin resistance [ 48,49resultingin inhibition of insulin - mediated glucose uptake and insulin resistance [ 48,49

potentiallycontributespotentially

to MHC co - expression within individual myofibersleadsto MHC co - expression within individual myofibers

in decreased levels of Vps34 and Beclin 1 partners in the complexresultedin decreased levels of Vps34 and Beclin 1 partners in the complex

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