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Qaagi - Book of Why

Causes

Effects

A decreased mechanical efficiency of leg exercise has been describedcould resultfrom a decreased efficiency of skeletal muscle energy metabolism

elevation of FFAleadsto decreased IκB - α in the skeletal muscles of healthy subjects

the molecular mechanismsleadingto transient insulin resistance affecting skeletal muscle after limited muscle damage in human subjects

to increase availability of this incredibly important energy ingredientpositively influencingefficiency of work of skeletal muscles

activating Rev - erbα with SR9009causedincreased metabolic activity in the skeletal muscle of mice

lipid - inducedER stresscausesIR in skeletal muscle through the phosphoryla - tion of IRS1/2 in an IRE1a - JNK dependent manner

physical inactivityresultsin reduced metabolic efficiency in skeletal muscle tissue

Loss of AMPK β2causesextensive loss of AMPK activity in skeletal muscle

chronic hypoxialeadsto an inexorable loss of skeletal muscle mass in healthy subjects

muscle mitochondrial volume , which varies from ∼6 % in type I fibers to ∼4 % in type II fibers , and the wide - ranging mitochondrial enzymatic activity in slow- and fast - twitch fibers ( 14(passive) is also influenced byThe heterogeneity of skeletal muscle metabolic efficiency

Gustafsson T. PGC-1alpha mRNA expression(passive) is influenced byGustafsson T. PGC-1alpha mRNA expression

1297244511.PGC-1alpha mRNA expression(passive) is influenced by1297244511.PGC-1alpha mRNA expression

2004 ) PGC-1{alpha } mRNA expression(passive) is influenced by2004 ) PGC-1{alpha } mRNA expression

PGC-1α mRNA expression(passive) is influenced byPGC-1α mRNA expression

PGC-1a mRNA expression(passive) is influenced byPGC-1a mRNA expression

the pace of building muscle masspositively influencesthe pace of building muscle mass

in collateral sprouting and an increase in the motor unit size ( Edds , 1953resultin collateral sprouting and an increase in the motor unit size ( Edds , 1953

in inhibition of insulin - mediated glucose uptake and insulin resistance [ 48,49resultingin inhibition of insulin - mediated glucose uptake and insulin resistance [ 48,49

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