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Qaagi - Book of Why

Causes

Effects

Placement in protein networksmay influenceevolutionary constraint

the presence or absence of biochemical reactions(passive) caused byevolutionary constraints

functional interdependency and maintained by internal selection or(passive) caused byBurden - Evolutionary constraints

additional genomic propertiesinfluencingevolutionary constraint

Fragmentation of natural populationscan leadto evolutionary constraints

requirements of function and stability(passive) set byevolutionary constraints

The differences between these five aphid species ... the symbiotic interactionscreatedspecific evolutionary constraints

the fitness costs associated with increased pleiotropy(passive) caused byevolutionary constraints

specificityresultingfrom evolutionary constraints

Pleiotropic genes affect multiple traits and underlie genetic covariance between traitsoften causingevolutionary constraints

postulatedto resultfrom the evolutionary constraints

to these preferences and what can we do about themleadto these preferences and what can we do about them

components of protein complexes and metabolic pathways to co - evolve while genes in signaling and transcriptional networks do notleadcomponents of protein complexes and metabolic pathways to co - evolve while genes in signaling and transcriptional networks do not

The limitation itself ... either lack of genetic variation , gene flow from central populations , or negative correlations and trade offs among fitness components ( Antonovics 1976b(passive) is caused byThe limitation itself ... either lack of genetic variation , gene flow from central populations , or negative correlations and trade offs among fitness components ( Antonovics 1976b

from limited genetic variance ( 41–44resultfrom limited genetic variance ( 41–44

from genetic trade - offs between traitsresultingfrom genetic trade - offs between traits

in a dichotomous situation where along any given primate lineage only one of these genes ( either TRIM5 or TRIM22to have resultedin a dichotomous situation where along any given primate lineage only one of these genes ( either TRIM5 or TRIM22

to human beingsledto human beings

from the need to maintain specific molecular activities as well as multiple interactions with other signaling componentsmay resultfrom the need to maintain specific molecular activities as well as multiple interactions with other signaling components

different phylogenetic lineages of algae to have different adaptations to the same environmental conditionsleaddifferent phylogenetic lineages of algae to have different adaptations to the same environmental conditions

adaptation to novel environments and lead to chronic diseases in humans and wildlife threatened by habitat changepreventadaptation to novel environments and lead to chronic diseases in humans and wildlife threatened by habitat change

to lifespan differences in vertebratesleadingto lifespan differences in vertebrates

the whelks from consuming prey that were more optimalwere preventingthe whelks from consuming prey that were more optimal

to more nonsynonymous substitution sites at otherwise conservative first and second codon positionsleadsto more nonsynonymous substitution sites at otherwise conservative first and second codon positions

from purifying selection against detrimental alternatives at a given nucleotide positionresultingfrom purifying selection against detrimental alternatives at a given nucleotide position

to convergent evolution of learned vocal communication in diverse taxa ( Scharff and Petri 2011contributingto convergent evolution of learned vocal communication in diverse taxa ( Scharff and Petri 2011

from structural or functional aspectsresultingfrom structural or functional aspects

in different folding and stabilization mechanismsresultingin different folding and stabilization mechanisms

from trade - offs between characters6.edu .resultingfrom trade - offs between characters6.edu .

These variations appear(passive) to be caused byThese variations appear

a further response to natural selectionhave preventeda further response to natural selection

in a strict correlation between brain and body massresultin a strict correlation between brain and body mass

to functional diversity in orthologous proteins ( Koonin 2005leadingto functional diversity in orthologous proteins ( Koonin 2005

to the replicability of orthologous proteins in highly divergent genomesleadto the replicability of orthologous proteins in highly divergent genomes

human anatomy and physiologyinfluencehuman anatomy and physiology

the interbreeding of speciespreventthe interbreeding of species

from fitness trade - offsresultingfrom fitness trade - offs

to small genome sizeleadingto small genome size

antagonistic epistases [ 75 ] in order to escape from the plant ’s immune response , and to preserve at the same time the HHR folds on both strands and the associated long - distance interactions necessary for catalytic efficiency ( Figure 4creatingantagonistic epistases [ 75 ] in order to escape from the plant ’s immune response , and to preserve at the same time the HHR folds on both strands and the associated long - distance interactions necessary for catalytic efficiency ( Figure 4

the sequence composition and diversity of mitochondrial matrix targeting signalsinfluencesthe sequence composition and diversity of mitochondrial matrix targeting signals

Any lack of adaptation(passive) might be caused byAny lack of adaptation

to this combination of stiffness , strength and toughnessledto this combination of stiffness , strength and toughness

the divergence of functional elements within this genehave preventedthe divergence of functional elements within this gene

PPI network properties(passive) caused byPPI network properties

from following one of three tumor suppressive pathwaysresultingfrom following one of three tumor suppressive pathways

This information(passive) is influenced byThis information

to one or the other enzymeleadingto one or the other enzyme

to the unusually high conservation of glycine at this positionleadingto the unusually high conservation of glycine at this position

most viruses to develop very high spike densityledmost viruses to develop very high spike density

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