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Typical drug - drug interactionsresultingfrom enzyme inhibition
the product ... a drugcausesenzymatic inhibition
a conformational changeresultsin enzyme inhibition
concomitant drug treatmentsmay have resultedin CYP2D6 enzyme inhibition
wherein a thiol scavenger is utilizedto preventinhibition of the LovD acyltransferase enzyme
modifications of human extracellular superoxide dismutaseresultsin enzyme inhibition
the scissile bondcausinginhibition of the enzyme [ 3519213
10.28.2016 Organophosphorus agents ( OPs ) , such as pesticides and chemical warfare agentscan causeenzyme inhibition of acetylcholinesterase
poisons or drugs(passive) caused byenzymatic inhibition
Technique switches enzyme activity on and off with light Keywords : inhibitor , selectivity , specificity An unnatural amino acid reacts with a tetrazine - inhibitor complexleadingto enzyme inhibition
S - Nitrosylation of eNOSleadsto enzyme inhibition
nerve agents(passive) caused byThe enzyme inhibition
the protein deactivationleadingto enzyme inhibition
Indeed the mycobacterial Pat ( protein lysine acetyltransferase ) , Rv0998 , specifically acetylates MbtA on lysine 546 , in a cAMP - dependent mannerleadingto enzyme inhibition
smaller dosescaused50–80 % enzyme inhibition
thiol modificationleadingto enzyme inhibition
Contraceptive steroids ... drugscauseenzyme inhibition
Protein AMKylation at tyrosinesmay causeinhibition of enzymes
Although truncated T4 RNA Ligase 2 can not turnover ATP , ATP can still bind to the remnants of the active siteleadingto inhibition of the enzyme
may involve binding to the cellular protein cytophilinresultingin inhibition of the enzyme
amino acid mutations ... the BCR - ABL kinase domainpreventenzyme inhibition by imatinib
a passivation layer ( not shown hereto preventinhibition of enzymes
Both the carbohydrate- and polyphenol - fractioncontributedto the enzyme inhibition
A clear picture of the enzymatic events in cataractogenesis will form the basis of drug developmentto causeselective enzyme inhibition
S- nitrosylation , a redox - sensitive post - translational modification of cysteine residuesleadsto TG2 enzyme inhibition
Saint John 's Wort Maycausehepatic enzyme inhibition
the nano - Ag using both purified cathepsins and a cell culture model(passive) caused byenzymatic inhibition
lipoamide dehydrogenase and mycobacterial proteasome ATPase , S - nitrosylationcausedenzyme inhibition [ 9
Some foods or drugs n eurontin enzyme induction35 and otherscauseenzyme inhibition
while the 1:1 complex was not effective ( 0.0031 min−1 mg protein−1to preventinhibition of the enzyme
Pharmacokinetic Interactions that Increase Drug Delivery to the Site of Action - Blood Pressure Pharmacokinetic Interactions that Increase Drug Delivery to the Site of Action INHIBITION OF DRUG - METABOLIZING ENZYMES For drugs whose clearance depends on biotransformationleadsinhibition of a metabolizing enzyme
Treatment with oxidant agents , such as diamide , hydrogen peroxide , glutathione and sodiumnitroprusside resultedin enzyme inhibition
releasing agents containing ionic surfactants , adding a surfactant with the opposite charge(passive) caused byenzyme inhibition
some similar chemical properties such as exerting inhibition on an enzyme ... may be usedto causeinhibition of biosynthetic enzyme
Prior to the reduction of the MTT , the divalent metal ion exists in a chelated stateto preventenzyme inhibition
TheHg2C ions have an affinity for sulfhydrylgroups ( SH ) in proteins , enzymes , serumalbumin , and hemoglobin to form complexesthereby causingenzyme inhibition
As a method for detecting an action on a gene or protein belonging to these gene group or protein group , a method for detecting specific binding of a test compound to a protein belonging to the protein groupcausesinhibition of enzyme activity
Methanol was added stepwise ( 33 % at reaction time 0 h and 67 % within 1 to 10 h ) at the specified molar ratio to treatments with enzymatic catalystto preventenzyme inhibition [ 3
Two strategies have been identifiedto preventenzymatic inhibition
orderto preventinhibition of the proteolytic enzymes
to folic acid deficiencymay leadto folic acid deficiency
drug - drug interactions and side effectsto preventdrug - drug interactions and side effects
development of muscle and nerve dysfunction and stimulates angiogenesis in streptozotocin - diabetic rats ( 1992preventsdevelopment of muscle and nerve dysfunction and stimulates angiogenesis in streptozotocin - diabetic rats ( 1992
from noncompetitive or competitive inhibition of CYP enzymes by a second drug , an effect that may occur rapidlymay resultfrom noncompetitive or competitive inhibition of CYP enzymes by a second drug , an effect that may occur rapidly
to improved chemotherapy and stem cell transplant results November 21 , 2012could leadto improved chemotherapy and stem cell transplant results November 21 , 2012
the development and induces regression of cardiac hypertrophy in ratspreventsthe development and induces regression of cardiac hypertrophy in rats
to improved chemotherapy and stem cell transplant results Blocking the action of one enzymecould leadto improved chemotherapy and stem cell transplant results Blocking the action of one enzyme
the breakdown of levodopapreventsthe breakdown of levodopa
ischemic retinopathymay preventischemic retinopathy
to an increase of hydrophilic and decrease of hydrophobic properties ... leading to a failure of the formation of the active center[31leadsto an increase of hydrophilic and decrease of hydrophobic properties ... leading to a failure of the formation of the active center[31
to increased liver function and microcirculation [ 43leadsto increased liver function and microcirculation [ 43
weight gain- Researchmay preventweight gain- Research
the formation of isoprenoidspreventsthe formation of isoprenoids
the formation of thromboxanepreventsthe formation of thromboxane
in high blood levels of sonidegib , leading to increased side effectsmay resultin high blood levels of sonidegib , leading to increased side effects
phenolic metabolite formationwould preventphenolic metabolite formation
intercellular gap formationpreventsintercellular gap formation
to a decrease in aqueous formationmight leadto a decrease in aqueous formation
a decrease in amyloid - beta protein ... 12/15-LO influences amyloidcausesa decrease in amyloid - beta protein ... 12/15-LO influences amyloid
a reduction in metabolism and subsequent increase in the concentration of biogenic aminescausesa reduction in metabolism and subsequent increase in the concentration of biogenic amines
reactivation of cortisone and glucocorticoid regulation of aromatase expression ( 70preventsreactivation of cortisone and glucocorticoid regulation of aromatase expression ( 70
the expression of these tumor - associated glycoproteins , resulting in good antitumor and antimetastatic activity without the usual cytotoxic effects of traditional chemotherapy agentspreventsthe expression of these tumor - associated glycoproteins , resulting in good antitumor and antimetastatic activity without the usual cytotoxic effects of traditional chemotherapy agents
to an increase in the level of polyunsaturationleadsto an increase in the level of polyunsaturation
some of the harmful effects of high glucosecould preventsome of the harmful effects of high glucose
to anti - androgen effects which may be responsible for breast enlargement effectsleadsto anti - androgen effects which may be responsible for breast enlargement effects
some antiproliferative effects on lung tumor growth(passive) to be caused bysome antiproliferative effects on lung tumor growth
an increase in the drug 's effectwill causean increase in the drug 's effect
to an increase in the intracellular concentration of sodiumleadsto an increase in the intracellular concentration of sodium
the increase in aortic collagen in ratspreventsthe increase in aortic collagen in rats
an increase in the blood acetaldehyde levelscausesan increase in the blood acetaldehyde levels
hypocitraturia rubric of complementary and alternativecauseshypocitraturia rubric of complementary and alternative
in enhanced susceptibility to pulmonary fungal infection , which is associated with lung fungal persistenceresultedin enhanced susceptibility to pulmonary fungal infection , which is associated with lung fungal persistence
the effects of atrial natriuretic factor on arterial baroreflexespreventsthe effects of atrial natriuretic factor on arterial baroreflexes
an increase in cortisone ( inactive form of cortisolcausesan increase in cortisone ( inactive form of cortisol
cellular respiration , which ultimately leads to death of the cellpreventscellular respiration , which ultimately leads to death of the cell
problems with cell reproduction and ultimately tumor growthcausesproblems with cell reproduction and ultimately tumor growth
in alleviation of the effects of insulin resistance in adipose tissue in humanswill resultin alleviation of the effects of insulin resistance in adipose tissue in humans
the effects of atrial natriuretic factor on baroreflex responses in humanspreventsthe effects of atrial natriuretic factor on baroreflex responses in humans
the formation of the metabolically active form of folic acid , tetrahydrofolic acidpreventsthe formation of the metabolically active form of folic acid , tetrahydrofolic acid
an increase of acetylcholine in the synapse of cholinergic nerve fiberswill causean increase of acetylcholine in the synapse of cholinergic nerve fibers