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Smart Reasoning:

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Qaagi - Book of Why

Causes

Effects

smoking cessation as being the most important interventionto preventworsening of COPD

by reducing smoking and improving air quality(passive) can be preventedWorsening of COPD

pulmonary comorbidities(passive) caused byheterogeneity of COPD

short courses of oral steriodscan preventworsening of COPD

NF - κB activation due to oxidative stress(passive) is caused byPAI-1 elevation in COPD lung

airway irritants and upper - respiratory infections(passive) are caused byExasperations of COPD

increased respiratory work ... increased intrathoracic negative pressures ... and increased left ventricular afterload(passive) is triggered byelevation in COPD

a healthy weight which can helppreventworsening of COPD

Advair is used to prevent patients from having asthma attacks ; Advair is also usedto preventworsening of COPD

Therefore , mannitol responsiveness may support decisions to refrain from inhaled steroid treatmentpreventingovertreatment of COPD

to increased risk for disability , lung infections , pneumonia , heart attack , and ischemic strokeleadsto increased risk for disability , lung infections , pneumonia , heart attack , and ischemic stroke

in unnecessary treatmentfrequently resultingin unnecessary treatment

to increased risk for heart attacks and ischemic strokes ( blockage of blood to the brain ... and the risk increases after a COPD exacerbationcan leadto increased risk for heart attacks and ischemic strokes ( blockage of blood to the brain ... and the risk increases after a COPD exacerbation

to treatment with systemic corticosteroids , or hospitalization or emergency department visits , or bothleadingto treatment with systemic corticosteroids , or hospitalization or emergency department visits , or both

from an inherited alpha-1 antitrypsin ( AAT ) deficiencyresultedfrom an inherited alpha-1 antitrypsin ( AAT ) deficiency

globallyhas promptedglobally

significantlycontributesignificantly

oftenleadsoften

to the development of a classification system with disease subgroupsledto the development of a classification system with disease subgroups

to Isolation and LonelinessCan Leadto Isolation and Loneliness

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