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Smart Reasoning:

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Qaagi - Book of Why

Causes

Effects

Impaired myocardial relaxationresultingin diastolic dysfunction [ i.e. , Heart failure with preserved ejection fraction ( HFpEF

These factorscan leadto left ventricular ejection fraction 10 % or symptomatic heart failure

Systolic HF ... weakened ventricular contractionsresultin heart failure with reduced ejection fraction ( HFrEF

Impaired cardiac relaxationalso contributesto a form of heart failure termed heart failure with preserved ejection fraction

Cardiac remodeling following myocardial infarctionleadsto heart failure with reduced ejection fraction

those processescan leadto heart failure with reduced ejection fraction

NO ) availabilitymay contributeto the pathophysiology of heart failure with preserved ejection fraction ( HFpEF

Rbm20 deficiency in the rat modelleadsto heart failure with reduced ejection fraction

myocardial systolic dysfunction with LV diastolic dysfunctioncould leadto heart failure with preserved ejection fraction ( HFpEF

ventricular diastolic dysfunctionleadingto heart failure with preserved ejection fraction ( HFpEF

diastolic dysfunctionleadingto heart failure with preserved ejection fraction ( HFpEF

left ventricular ( LV ) diastolic dysfunctionleadingto heart failure with preserved ejection fraction ( HFpEF

diastolic dysfunction , which is a heart relaxation abnormalitycontributesto heart failure with preserved ejection fraction ( HFpEF

oxidative stress and vascular dysfunctioncontributeto heart failure with preserved ejection fraction ( HFPEF

a heart relaxation abnormalitycontributesto heart failure with preserved ejection fraction ( HFpEF

The mechanismcausingheart failure with preserved ejection fraction ( HFPEF

NO ) availabilitymay contributeto the pathophysiology of heart failure with preserved ejection fraction

oxidative stress and vascularcontributeto heart failure with preserved ejection fraction ( HFPEF

Mechanismsleadingto symptomatic heart failure with preserved ejection fraction

Microvascular functions such as control of blood flow and inflammationcontributeto heart failure with preserved ejection fraction ( HFpEF

Cardiac fibrosis ... diastolic dysfunctioncan ... resultin heart failure with preserved ejection fraction

by diastolic dysfunction(passive) caused bypreserved ejection fraction Heart failure

a diastolic dysfunctionresultingin heart failure with preserved ejection fraction

diastolic dysfunctioncan ... leadto heart failure with preserved ejection fraction

enlargement of the left ventricle wall(passive) is caused byHeart failure with preserved ejection fraction

Stiffening of the left ventriclecontributesheart failure with preserved ejection fraction

Other devicesmay causeheart failure with preserved ejection fraction

your childmay resultin preserved ejection fraction heart disease

The addition of VEGF into the transfection cocktailresultedin a 4-fold improvement in the cardiac ejection fraction

RSK3-mAKAP signaling , a signal transduction network that is involved in cardiac remodeling ... cardiovascular diseaseresultsin heart failure with preserved ejection fraction

infiltrative disorders(passive) caused byventricular ejection fraction in RCM

Given its crescentic shape and higher capacitance , the RV volume is larger than the LV volumeresultingin a lower right ventricular ejection fraction ( RVEF

Systolic HF(passive) is caused bySystolic HF

The problem(passive) was discoveredThe problem

in an elevated RAPwould resultin an elevated RAP

The drug(passive) is designedThe drug

in excluding a large proportion of heart failure patients from treatment trialshas resultedin excluding a large proportion of heart failure patients from treatment trials

to HFpEFcontributeto HFpEF

to exercise intolerance in obesitymay contributeto exercise intolerance in obesity

to filling abnormalitiescontributesto filling abnormalities

the heart to pump out less blood than normalcausesthe heart to pump out less blood than normal

to decreased stroke volumeleadsto decreased stroke volume

lung remodeling characterized by myofibroblasts proliferation and fibrosis leading to a restrictive lung syndrome contributing to PH and RV dysfunctioncauseslung remodeling characterized by myofibroblasts proliferation and fibrosis leading to a restrictive lung syndrome contributing to PH and RV dysfunction

lung remodelling with myofibroblasts proliferation and fibrosis leading to a restrictive lung syndrome with pulmonary hypertension ( PH ) and right ventricular ( RV ) dysfunctioncauseslung remodelling with myofibroblasts proliferation and fibrosis leading to a restrictive lung syndrome with pulmonary hypertension ( PH ) and right ventricular ( RV ) dysfunction

The company 's interatrial shunt device ( IASD ) , a trans - catheter device and non - surgical medical device(passive) is designedThe company 's interatrial shunt device ( IASD ) , a trans - catheter device and non - surgical medical device

to heart failure hospitalizationscontribute equallyto heart failure hospitalizations

when myocardial contractility is decreased throughout the left ventricleresultswhen myocardial contractility is decreased throughout the left ventricle

HFpEFresultsHFpEF

in an elevated RAPwould resultin an elevated RAP

after a widow maker , triple blockagediscoveredafter a widow maker , triple blockage

shortness of breathcan causeshortness of breath

in shortness of breath , palpitationsmay resultin shortness of breath , palpitations

in shortness of breath , palpitations , and/ormay resultin shortness of breath , palpitations , and/or

in shortness of breath , palpitations or fatiguecan resultin shortness of breath , palpitations or fatigue

from some kind of Cardiomyopathy , a condition in which the heart is abnormally enlarged , thickened or stiffenedmay resultfrom some kind of Cardiomyopathy , a condition in which the heart is abnormally enlarged , thickened or stiffened

to shorter bouts of exercise being possibleleadsto shorter bouts of exercise being possible

shortness of breathcan causeshortness of breath

in the heart muscle not being able to contract forcefully enough to pump adequate amounts of blood to vital organs , leading to arrhythmias , blockage of a blood vessel by blood clots and ... in some cases , sudden cardiac deathresultsin the heart muscle not being able to contract forcefully enough to pump adequate amounts of blood to vital organs , leading to arrhythmias , blockage of a blood vessel by blood clots and ... in some cases , sudden cardiac death

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Smart Reasoning:

C&E

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