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membrane lipid compositioninfluencesdrug action at membrane proteins
the hypothesis ... membrane lipid compositioninfluencesdrug action at membrane proteins
bile acids and drug moleculescan influencethe drug transport across the biological membranes
Nanoparticlesare designedto deliver drugs beyond the membrane
< p > Nanoparticlesare designedto deliver drugs beyond the membrane
The physicochemical properties of drugsinfluencethe passage of drugs across biologic membranes
The changes in the membrane componentsleadto increased membrane fluidity
The changes in membrane lipid compositionleadto a higher membrane fluidity
fatty acid compositionresultingin increased membrane fluidity
the cholesterolleadingto increased membrane fluidity
likelyto resultin increased membrane fluidity
perturbs their structureresultingin increased membrane fluidity
High temperaturesleadto increased fluidity of the membrane
DHA and EPAcausedincreased membrane fluidity
drug ... in turncausesthe drug to permeate through the membrane
to result in a shift in the relative proportion of ionized and unionized species of amantadine by virtue of the weak base characteristic of the druginfluencingpassage of the drug through the membrane
2009 scientistsdiscoverdrugs to strengthen synapses
2009 scientistsdiscoverdrugs to strengthen synapses ...
by increased content in unsaturated fatty acids(passive) caused bycellular membrane fluidity
It is knowninfluencescellular membrane fluidity
Albumin concentrationinfluencesuptake of drugs
the factorsinfluencingthe permeability of drugs
knownto influencethe permeability of drugs
Variations in the length and saturation of the fatty acid tail affect how tightly phospholipids are able to pack against each otherleadingto altered membrane fluidity
Hydration of the nail plate ... an important factorinfluencesdrug permeability
The coagulation zone ( CZ ) surrounding vertically ablated channelsmay influenceuptake of drugs
The mosaic nature of the membrane , its phospholipid chemistry , and the presence of cholesterolcontributeto membrane fluidity
by altered membrane lipid content(passive) caused bymembrane fluidity
) . Cholesterol is also present , ... , and there are various proteins embedded within the membrane that have a variety ocontributesto the fluidity of the membrane
by temperature and membrane composition 3(passive) is influenced bymembrane fluidity
temperature and membrane composition(passive) is influenced bymembrane fluidity
by membrane composition and temperature(passive) is influenced bymembrane fluidity
by temperature and membrane composition(passive) is influenced bymembrane fluidity
by temperature and membrane composition(passive) is influencedmembrane fluidity
by membrane composition and temperature(passive) is influencedmembrane fluidity
lipidscausingaltered cell membrane fluidity
In model membranes , free cholesterol interacts with phospholipids and sphingolipidsto influencemembrane fluidity
by membrane composition(passive) is influenced bymembrane fluidity
by membrane composition(passive) is influencedmembrane fluidity
the components of the membrane(passive) is also influenced byMembrane fluidity
in increased intracellular concentrations of an anticancer drugmay resultin increased intracellular concentrations of an anticancer drug
nephrotic syndromecan causenephrotic syndrome
in better efficacyresultingin better efficacy
more complicationsto causemore complications
the drug release ratedoes ... influencethe drug release rate
in better efficacyresultingin better efficacy
drug transport , absorption , distribution , selectivity , efficacy , and resistancecan influencedrug transport , absorption , distribution , selectivity , efficacy , and resistance
to hyperkalemiacontributingto hyperkalemia
to drug - susceptible cellsleadingto drug - susceptible cells
due horizontal stenosiscausedue horizontal stenosis
Nanoparticles(passive) are designedNanoparticles
to resistancecontributesto resistance
signal transductioninfluencingsignal transduction
change(s ... in an organisms ( or individuals ) physiology or psychology.causeschange(s ... in an organisms ( or individuals ) physiology or psychology.
to interact with APCsdesignedto interact with APCs
to interact with APCs to regulate cytokine levels and control inflammationdesignedto interact with APCs to regulate cytokine levels and control inflammation
memory loss with alcoholcausememory loss with alcohol
suppression of bone marrowcan causesuppression of bone marrow
to increased permeability of the membraneleadsto increased permeability of the membrane
an opioid effect like heroin , OxyContin , and methadonecausean opioid effect like heroin , OxyContin , and methadone
in enhanced passive diffusion of the drugs ( 30resultingin enhanced passive diffusion of the drugs ( 30
alsoresultsalso
Atypical pneumonia(passive) caused byAtypical pneumonia
off - target effectscan ... causeoff - target effects
otitis media(passive) caused byotitis media
adrenergic responsescan influenceadrenergic responses
latation(passive) caused bylatation
greater uptake of auranofin(passive) could be influenced bygreater uptake of auranofin
Impaired Renal Function Changes in renal function including acute renal failure(passive) can be caused byImpaired Renal Function Changes in renal function including acute renal failure
decreased clearance of methadone which could lead to an increase in methadone plasma concentrations and result in increased or prolonged opioid effectsmay causedecreased clearance of methadone which could lead to an increase in methadone plasma concentrations and result in increased or prolonged opioid effects
decreased clearance of fentanyl which could lead to an increase in fentanyl plasma concentrations and result in increased or prolonged opioid effectsmay causedecreased clearance of fentanyl which could lead to an increase in fentanyl plasma concentrations and result in increased or prolonged opioid effects
The growth , much faster than 2017(passive) was led byThe growth , much faster than 2017
in improved delivery of nutrients and removal of waste build - upresultingin improved delivery of nutrients and removal of waste build - up
in lower operating costsresultsin lower operating costs
to various advantages for the user such as improvement in memorizing abilities ... and enhance cognition among the elderly , and improved learning abilities among other benefitsleadsto various advantages for the user such as improvement in memorizing abilities ... and enhance cognition among the elderly , and improved learning abilities among other benefits
to increased membrane permeabilityleadingto increased membrane permeability
in altered membrane protein activityresultsin altered membrane protein activity
the activity of membrane - bound enzymescan influencethe activity of membrane - bound enzymes
reduced insulin binding to receptors on cellular membranes and reduced insulin actioncausesreduced insulin binding to receptors on cellular membranes and reduced insulin action
sperm immobilitycausessperm immobility