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the replication itselfcan causedouble strand breaks to form
H2AX phosphorylation ... DNA damaging agentscausedouble strand breaks ( DSBs
DNA damaging agentscausedouble strand breaks ( DSBs
some elementscould causedouble - strand break
Inhibition of PARP enzymes induces persistence of single strand breaks ( SSBscan causedouble strand breaks ( DSBs
in the chromosome(passive) is causedA double - strand break
which attack DNAto causedouble - strand breaks ( DSBs
agentscauseDSBs ( double - strand breaks
some agentscausedouble - strand breaks ( DSBs
by these agents(passive) caused byDouble strand breaks ( DSBs
by DNA replication or ionizing radiation(passive) caused byDouble - strand breaks ( DSBs
the DNA ... hydrogen peroxide molecules present in the cellcan causedouble - strand breakage
Genotoxic agentscausedouble - strand breaks ( DSBs
The requirement of two gRNA - mediated nicks nearbyto causea double - strand break
so that the wild - type Cas can cut both strands of DNAcausinga double strand break
DNA damagecausingdouble strand breaks ( DSBs
by DNA damage(passive) caused bydouble - strand breaks ( DSBs
changes in homologous recombination frequencies and sensitivity to agentscausedouble strand breaks ( DSBs
the expression of the protein ... in timecausesdouble strand breaks ( DSBs
their processingmay ... leaddouble strand breaks ( DSBs
by oxidative stress(passive) caused bydouble - strand breaks ( DSBs
examplecausingdouble strand breaks ( DSBs
especially conditionscausingdouble - strand breaks ( DSBs
by RT [ 7 , 48(passive) caused bydouble - strand breaks ( DSBs
DNAcausingdouble strand breaks ( DSB
free radicals generated from ionizing radiation in the environment and from by - products released continually during cellular metabolism(passive) are mainly caused byDouble strand breaks DSBs
Radiationcausesdouble - strand breaks ( DSB
R - tracts in their DNAleadto irreparable double - strand breaks
These lesionscan leadto deleterious double - strand breaks
the double rnhAB mutants accumulate R - tracts in their DNAleadto irreparable double - strand breaks
DNA damage and chromosome aberrations and sensitivity to DNA - damaging agentscausedouble - strand breaks
DNA damage and chromosome aberrations and sensitivity ... DNA - damaging agentscausedouble - strand breaks
PARP inhibition ... DNA single - strand breakscan ... leadto double - strand breaks
These DNA damaging agents ... inhibitors of DNA gyrasecausedouble - strand breaks
by DNA damaging agents(passive) caused bydouble strand breaks
DNA - damaging agentscausedouble - strand breaks
these specific DNA sitescausesdouble strand breaks
DNA topoisomerase IIcausesdouble strand breaks
DNA single - strand breakscan ... leadto double - strand breaks
the accumulation of single - strand breaks in the DNA ... in turncan ... leadto double - strand breaks
cancer via chromosomal rearrangementscausecancer via chromosomal rearrangements
to the formation of cancerous tumorscan leadto the formation of cancerous tumors
cell deathcausingcell death
to the release of double - strand DNA in the cytoplasm of the tumor cellsleadto the release of double - strand DNA in the cytoplasm of the tumor cells
in cellresultin cell
to cell death ( 31leadingto cell death ( 31
from oxidation ... ionizing radiation and replication errorscan resultfrom oxidation ... ionizing radiation and replication errors
to genomic alterationsleadingto genomic alterations
chromosomal rearrangements , such as deletions , translocations , and fusions of DNAcausechromosomal rearrangements , such as deletions , translocations , and fusions of DNA
Federation of Indian Rationalistto ... leadsFederation of Indian Rationalist
anaphase bridges(passive) may be caused byanaphase bridges
to high frequencies of deletions within short CAG CTG trinucleotidecan leadto high frequencies of deletions within short CAG CTG trinucleotide
to genome rearrangementscan leadto genome rearrangements
to chromosome aberrations and cell deathleadto chromosome aberrations and cell death
to the loss of genetic information and cell deathcan leadto the loss of genetic information and cell death
cell deathleadcell death
to cell deathleadto cell death
to instability of the genomecan leadto instability of the genome
in covalent attachment between active site residues of topoisomerase II and the 5 ' of the DNA ends [ 10 , 12 , 14resultingin covalent attachment between active site residues of topoisomerase II and the 5 ' of the DNA ends [ 10 , 12 , 14
to DNA damageleadto DNA damage
to recombination eventsleadingto recombination events
to cell cycle arrestleadingto cell cycle arrest
to a total blockade of transcription of the genes affected by the breakwas leadingto a total blockade of transcription of the genes affected by the break
in mutant plants with either gene knock - outs ( via non - homologous end joining ( NHEJ ... or gene replacements and insertions ( via homology - directed repair ( HDRresultin mutant plants with either gene knock - outs ( via non - homologous end joining ( NHEJ ... or gene replacements and insertions ( via homology - directed repair ( HDR
several human diseasescan causeseveral human diseases
from the attack of both DNA strands by multiple sources , including radiation and chemicalsresultfrom the attack of both DNA strands by multiple sources , including radiation and chemicals
to temporary loss of genetic informationcan leadto temporary loss of genetic information
to disruption of the reading frameleadingto disruption of the reading frame
to mutationsleadingto mutations
to genetic instabilitycontributeto genetic instability
from endonucleolytic cleavage of both strands of DNAresultfrom endonucleolytic cleavage of both strands of DNA
erroneous DNA repairto causeerroneous DNA repair
cell death(passive) caused bycell death
in cell deathusually resultsin cell death
cancerwill causecancer
to either cell cycle arrestleadingto either cell cycle arrest
to either cell cycle arrest , apoptosisleadingto either cell cycle arrest , apoptosis
in insertion / deletion mutations ( " indelsresultsin insertion / deletion mutations ( " indels
to DNA damage checkpoint arrest , orleadingto DNA damage checkpoint arrest , or
cell deathcausecell death