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ionizing radiation or radiomimetic agents(passive) caused bydouble - strand breaks ( DSB
agents such as ionizing radiation(passive) caused bydouble - strand breaks
Genotoxic ionizing radiation and DNA - damaging agentscan causedouble - strand breaks ( DSBs
the propensity of ionizing radiationto causedouble - strand breaks
ionizing radiation and radiomimetic drugs(passive) are ... caused bydouble - strand breaks
AT cells ... agentscausedouble - strand breaks
82 ] A. Kuzminov , Single - strand interruptions in replicating chromosomescausedouble - strand breaks
exogenous and endogenous mechanisms , such as ionizing radiation , reactive oxygen species , or replication fork collapse [ 1]–[5(passive) can be caused bydouble - strand breaks ( DSBs
various DNA - damaging agentscausingdouble - strand breaks ( DSBs
DNA damaging agents in vivo(passive) caused bydouble strand breaks
ionizing radiation and ultraviolet lightto causedouble - strand breaks
ionizing radiation and radiomimetic compounds(passive) caused bydouble - strand breaks ( DSBs
These DNA damaging agents ... inhibitors of DNA gyrasecausedouble - strand breaks
ionizing radiation and V(D)J recombination(passive) created bydouble - strand breaks
cells ... DNA damageleadsto double strand breaks
Ionizing radiation can damage the DNA molecule both directly ,resultingin double - strand breaks
They inhibit topoisomerase IIthus causingdouble strand breaks
These DNA damaging agents ... DNA gyrasecausedouble - strand breaks
H2AX phosphorylation ... DNA damaging agentscausedouble strand breaks ( DSBs
Sources of exogenous DNA damage like ionizing radiationcan causedouble strand breaks
A single electron track of ionizing radiationcan causedouble - strand breaks
CRISPR - Cas9 technologycreatesdouble - strand breaks ( DSBs
In the study , researchers irradiated cellsto createdouble strand breaks
transposon excision [ 56(passive) caused bythe double strand breaks
CRISPR - Cas9 genome editing(passive) created bydouble - strand breaks ( DSBs
Ionizing radiation ( IR ) , which is widely used for the treatment of cancercausesdouble - strand breaks ( DSBs
the endonuclease Cas9(passive) caused bythe double - strand breaks
Cas9 endonuclease(passive) caused bydouble - strand breaks
ionizing radiation , chemicals , and reactive oxygen species(passive) may also be caused byDouble - strand breaks
ionizing radiation , which is used in breast cancer therapy(passive) are also caused byDouble strand breaks
1383 - 1389 DNA replication forks that collapse during the process of genomic duplicationleadto double - strand breaks
Mol Microbiol 16 : 373 - 384 Kuzminov A ( 2001 ) Single - strand interruptions in replicating chromosomescausedouble - strand breaks
DNA damage and chromosome aberrations and sensitivity ... DNA - damaging agentscausedouble - strand breaks
2013;12:393 - 4.Google Scholar Kuzminov A. Single - strand interruptions in replicating chromosomescausedouble - strand breaks
These sequence - specific nucleasescreatedouble strand breaks ( DSBs
interference with the topoisomerase II enzymeleadingto double - strand breaks
normal metabolic processes or exogenous DNA damaging agents(passive) may be caused bydouble - strand breaks ( DSBs
FUS ... agentscauseDSBs ( double - strand breaks
doxorubicin and other agentscausingdouble - strand breaks
the chromosomes of cells lacking HIRA ... genotoxic agentscausedouble strand breaks
DNA damage checkpoints(passive) triggered byDNA damage checkpoints
from ionizing radiation and other types of DNA damage ( 6resultingfrom ionizing radiation and other types of DNA damage ( 6
to chromosome aberrations and cell death and also generates a variety of oxidative DNA damageleadto chromosome aberrations and cell death and also generates a variety of oxidative DNA damage
early senescence ( see DNA damage theory of agingwould ... causeearly senescence ( see DNA damage theory of aging
to apoptosis if cells suffer from extensive DNA damage [ 26–28may ... leadto apoptosis if cells suffer from extensive DNA damage [ 26–28
to cell death[69leadsto cell death[69
to immediate cell deathcan leadto immediate cell death
to cell death [ 3leadto cell death [ 3
cell death.[68to causecell death.[68
to chromosomal aberrations only in cells with impaired ATM - dependent DNA - damage signalingleadto chromosomal aberrations only in cells with impaired ATM - dependent DNA - damage signaling
in cell death if the DSBs are not repairedresultin cell death if the DSBs are not repaired
to mitotic catastrophe and cell deathleadingto mitotic catastrophe and cell death
in cell death or genetic alterationscan resultin cell death or genetic alterations
to cell death of the tumor and its SSTR - positive lesions [ 8leadingto cell death of the tumor and its SSTR - positive lesions [ 8
to the loss of genetic information and cell deathcan leadto the loss of genetic information and cell death
to gross chromosomal rearrangements , cell - cycle arrest , and cell deathmay leadto gross chromosomal rearrangements , cell - cycle arrest , and cell death
to cell death in a process referred to as synthetic lethalityleadsto cell death in a process referred to as synthetic lethality
to cell death if not fixed by homologous recombination.1can leadto cell death if not fixed by homologous recombination.1
to either cell cycle arrest , apoptosis , or senescence too binary options nfpleadingto either cell cycle arrest , apoptosis , or senescence too binary options nfp
to temporary arrest of the cell cycle 32 Becker and Armani lumenleadingto temporary arrest of the cell cycle 32 Becker and Armani lumen
genetic instability that leads to malignant transformation or cell deathcausegenetic instability that leads to malignant transformation or cell death
by ionizing radiation or radiomimetic agentscausedby ionizing radiation or radiomimetic agents
to genomic instability and cancer if unrepairedmay leadto genomic instability and cancer if unrepaired
DNA ends(passive) caused byDNA ends
to activation of the immune system either through increased neoantigens and activation of the STING pathway , which is a very important pathway involved in innate immunitycan leadto activation of the immune system either through increased neoantigens and activation of the STING pathway , which is a very important pathway involved in innate immunity
from endonucleolytic cleavage of both strands of DNAresultfrom endonucleolytic cleavage of both strands of DNA
to intrinsic and extrinsic apoptosis and autophagy cell death pathways which are mediated by the p38 MAP kinaseleadingto intrinsic and extrinsic apoptosis and autophagy cell death pathways which are mediated by the p38 MAP kinase
to accumulation of genome instability and cell death for the low fidelity Germline mutations in BRCA1/2leadto accumulation of genome instability and cell death for the low fidelity Germline mutations in BRCA1/2
from oxidation , ionizing radiation , replication errors and certain metabolic products in cellsresultingfrom oxidation , ionizing radiation , replication errors and certain metabolic products in cells
from errors in DNA replication or exposure to ionizing radiation and genotoxic chemicalscan resultfrom errors in DNA replication or exposure to ionizing radiation and genotoxic chemicals
in disruption of homologous recombination repair in human lung cells Abstract 2120resultingin disruption of homologous recombination repair in human lung cells Abstract 2120
to temporary arrest of the cell cycle Transfection by Optical Injection 95leadingto temporary arrest of the cell cycle Transfection by Optical Injection 95
Chromosomal translocation(passive) is caused byChromosomal translocation
from ionizing radiation and from gene rearrangement in germ - line lymphoid cells ( 27resultingfrom ionizing radiation and from gene rearrangement in germ - line lymphoid cells ( 27
from normal cellular processes including replication and exogenous sources such as ionizing radiationresultingfrom normal cellular processes including replication and exogenous sources such as ionizing radiation
from reactive oxygen species generated by exposure to UV and ionizing radiationresultingfrom reactive oxygen species generated by exposure to UV and ionizing radiation
in chromosomal fragmentation , translocation and deletionscan also resultin chromosomal fragmentation , translocation and deletions
from exposure to ionizing radiation , oxidative damage and the spontaneous cleavage of the sugar - phosphate backbone of the DNA moleculecan resultfrom exposure to ionizing radiation , oxidative damage and the spontaneous cleavage of the sugar - phosphate backbone of the DNA molecule
to fragmentation of the DNAleadsto fragmentation of the DNA
to chromosome fragmentationcan leadto chromosome fragmentation