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Qaagi - Book of Why

Causes

Effects

These symptoms are caused by a degeneration of dopaminergic neurons of the substantia nigraleadingto a deficiency of dopamine in their striatal projection areas

serotonin antidepressantsmay ... influencedopamine pathways

Cocaine works by blocking dopamine receptors in the braincausingdopamine to build up in the synapses

This drugcausesDopamine to be secreted

low Dopamine levels Various Treatment Options Types of Treatments for PD Goals(passive) Caused byDopamine 's biosynthetic pathway

The up - regulation of Serotonin pathwaysleadsto the hypofunction dopamine pathways

Long term usecausesdisruption of the dopamine pathways

that repetitive stimulation of the cerebral cortexcausesdopamine release in the striatal projection of the stimulated area

RS 42358 197influencesthe reward methods within the mesolimbic dopamine projection

the use of antipsychoticsto influencedopamine pathways

in the ventral tegmental area and projecting to the nucleus accumbens ( Nacc ) and medial prefrontal cortex ( MPCoriginatingin the ventral tegmental area and projecting to the nucleus accumbens ( Nacc ) and medial prefrontal cortex ( MPC

in return the hypocretin tonemay influencein return the hypocretin tone

multiple transcriptional alterations within postsynaptic DARPP-32-related signal transduction systemscausedmultiple transcriptional alterations within postsynaptic DARPP-32-related signal transduction systems

to underactivation of basal ganglia thalamo - cortical loopsultimately leadingto underactivation of basal ganglia thalamo - cortical loops

to the cognitive impairments observed in schizophrenia and that this dopamine imbalance might be related , inasmuch as a deficiency in cortical dopamine function might translate into disinhibition of subcortical dopamine activitycontributeto the cognitive impairments observed in schizophrenia and that this dopamine imbalance might be related , inasmuch as a deficiency in cortical dopamine function might translate into disinhibition of subcortical dopamine activity

to increased levels of prolactin causing the array of previosly mentioned symptoms What does low levels of dopamine cause increase levels of prolactinleadsto increased levels of prolactin causing the array of previosly mentioned symptoms What does low levels of dopamine cause increase levels of prolactin

to the hypohedoniamay contributeto the hypohedonia

to frontal lobe hypoactivity often associated with apathy and withdrawal in schizophreniamay contributeto frontal lobe hypoactivity often associated with apathy and withdrawal in schizophrenia

to frontal lobe hypoactivity often associated with negative symptoms including apathy and social withdrawal in schizophreniamay contributeto frontal lobe hypoactivity often associated with negative symptoms including apathy and social withdrawal in schizophrenia

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