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Qaagi - Book of Why

Causes

Effects

no serotonincausingany inhibition of dopamine release

this drugcausesstrong dopamine reuptake inhibition

cytokines(passive) may be caused byInhibition of neurotransmitter release

nerve cellscausesinhibition of neurotransmitter release

if you are on a SSRIcan causethe inhibition of dopamine delivery

multiple mechanismsleadto the inhibition of dopamine uptake

highest affinity for vesicular monoamine transporter - twoleadingto the inhibition of dopamine uptake

calcium and potassium influxcausesneuronal inhibition

the synapsecausingneuronal inhibition

TMScausesneuronal inhibition

a reduction in the probability of action potential initiationcausingneuronal inhibition

A reduction in the probability of action potential generationcausesneuronal inhibition

Activation of GIRK by mGluRsshould causeneuronal inhibition

Acetylcholinecausesinhibition of Dopamine

endorphinscausingdopamine inhibition

electrical stimulation of the VTAcausesdopamine release.26

The American diet ... foodscan ... causedopamine depletion

stimulant medicationscan causedopamine depletion

Acute and repeated stimulation of dopamine receptorscan influencedopamine uptake

by excess dopamine agonism(passive) caused bydopamine downregulation

Another biological factor that is knownto influencedopamine uptake

glutamatecausesdopamine uptake

by glutamate(passive) caused bydopamine uptake

So glutamatecausesdopamine uptake

suggestingmay influencedopamine uptake

Hyperarousal dopamine spikescausedopamine dysregulation

knownto influencedopamine neurotransmission

by the degeneration of certain neurons in the brain(passive) caused bythe neurotransmitter dopamine

by genetic factors(passive) caused bythe neurotransmitter , dopamine

by the SSRI(passive) caused bydopamine neurotransmitter

the happiness and pleasure areascausingthe neurotransmitter dopamine

importance of genetic variance , epigenetic modification of DRD2 receptor gene , as well as functional striatal activation , knownto influencedopamine neurotransmission

Patients In some patientsmay causedopamine agonists

by the degeneration of the dopaminergic neurons of the substantia nigra(passive) caused bydopamine

by the loss of dopamine - producing cells in the substantia nigra area of the brain(passive) caused bydopamine

by the depletion of dopaminergic neurons in the substantia nigra(passive) is caused byDopamine

by cocaine or other drugs of abuse(passive) caused bydopamine

Decreased brain levels of the neurotransmitters norepinephrine , serotonin ( 5-HT ) , andmay causedopamine

by the loss of dopaminergic neurons(passive) caused bydopamine

by dopamine ( this type of drug is called a dopamine agonist(passive) are influenced bydopamine

y ... ( Fig(passive) caused byy ... ( Fig

to addictioncan leadto addiction

to greater amounts in the brainleadsto greater amounts in the brain

strong stimulant effectscan causestrong stimulant effects

to an enhancement of dendritic responses to excitation as well as enhancement of dendritic Ca2leadsto an enhancement of dendritic responses to excitation as well as enhancement of dendritic Ca2

reallyshould ... leadreally

certainlyshould ... resultcertainly

to neuronal hyperexcitability in the spinal cord and the thalamusleadingto neuronal hyperexcitability in the spinal cord and the thalamus

to hyperexcitation of the central nervous systemleadsto hyperexcitation of the central nervous system

movement , learning , attention and emotion ... excess causes schizophrenia , lack of causes tremors and parkinsons diseaseinfluencesmovement , learning , attention and emotion ... excess causes schizophrenia , lack of causes tremors and parkinsons disease

in an increase in extracellular dopamineresultingin an increase in extracellular dopamine

this feeling of pleasure to lastcausingthis feeling of pleasure to last

to muscleleadingto muscle

to positive symptoms of schizophreniacontributingto positive symptoms of schizophrenia

in the effective iresultingin the effective i

to the improvement of focus or concentrateleadingto the improvement of focus or concentrate

depressioncan causedepression

depression , anxiety , poor concentration , and feeling spaced outcan causedepression , anxiety , poor concentration , and feeling spaced out

in an increase of extracellular dopamine levels in the brain effects on the dopaminemay resultin an increase of extracellular dopamine levels in the brain effects on the dopamine

to either loveleadsto either love

to addictioncontributesto addiction

to positive symptoms of schizophrenia ( paranoia , hallucinations , delusions , and bizarre behaviorcontributingto positive symptoms of schizophrenia ( paranoia , hallucinations , delusions , and bizarre behavior

more stresscausemore stress

arousalcausesarousal

in antidepressant or mood enhancement effectsmay resultin antidepressant or mood enhancement effects

positive mooddoes ... influencepositive mood

to increased concentrations of the neurotransmitter in the brainleadingto increased concentrations of the neurotransmitter in the brain

positive mood in humansdoes ... influencepositive mood in humans

in increased extracellular dopamine levels in the brainmay resultin increased extracellular dopamine levels in the brain

in an increase of extracellular dopamine levels in the brainmay resultin an increase of extracellular dopamine levels in the brain

extracellular dopamine increasecausesextracellular dopamine increase

to increased levels of intracellular dopamineleadsto increased levels of intracellular dopamine

drowsinesscausesdrowsiness

a decrease in disorder in the brain causing the neurons of Parkinson 's diseasecausesa decrease in disorder in the brain causing the neurons of Parkinson 's disease

to feelings of pleasure and positive mood statesmay contributeto feelings of pleasure and positive mood states

an intense rush of pleasure or prolonged sense of euphoriacausingan intense rush of pleasure or prolonged sense of euphoria

feelings of pleasure and improved moodcausesfeelings of pleasure and improved mood

to feelings of : alertness focus motivation happinesscontributesto feelings of : alertness focus motivation happiness

feelings of pleasure and euphoriacausesfeelings of pleasure and euphoria

in feelings of pleasure or euphoriaresultsin feelings of pleasure or euphoria

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