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Qaagi - Book of Why

Causes

Effects

• Diseasesmay causeimpaired diffusion

a decreased diffusing capacity of the alveolar capillary membrane in 89 %(passive) was caused byDiffusion impairment

fibrosis or damaged pulmonary epithelium in the absence of significant airway function change ( HSIA , 2002).Although many of these tests are routinely employed to assess the severity of lung disease and disease progression , their sensitivity for the assessment of early development of toxicity to inhaled medication needs to be established and remains under investigation(passive) caused bydiffusion impairments

water loss ( Miermont et al . , 2013(passive) caused byimpaired diffusion

thickened alveolar septa(passive) caused bydiffusion impairment

Pathophysiology of postoperative delirium : systemic inflammation as a response to surgical traumacausesdiffuse microcirculatory impairment

des pulmonary oedemacausea diffusion impairment

Damage to cell membranescausesimpairment of diffusion

the only obstructive diseasecausesa diffusion impairment

that involves gradual replacement of the lung parenchyma with fibrotic tissueresultingin diffusion impairment

two clinical conditionscausediffusion impairment

Type 1 Respiratory failure with hypoxia with a normal or low pCO2causesType 1 Respiratory failure with hypoxia with a normal or low pCO2

hypoxaemia(passive) is caused byhypoxaemia

Low PAo2 caused by hypoventilation or high altitude(passive) is causedLow PAo2 caused by hypoventilation or high altitude

Limitation of carbon di oxide transfer in the lung(passive) caused byLimitation of carbon di oxide transfer in the lung

from an impediment of oxygen transfer from the alveolus to the pulmonary capillaryresultsfrom an impediment of oxygen transfer from the alveolus to the pulmonary capillary

to hypoxemiacontributeto hypoxemia

to V / Q mismatch and shunting What changes to arterial blood gases ( partial pressureleadingto V / Q mismatch and shunting What changes to arterial blood gases ( partial pressure

to decreased pulmonary oxygenation efficiencymay ... leadto decreased pulmonary oxygenation efficiency

the A - aDO2(passive) caused bythe A - aDO2

the PaCO2 to risedoes causethe PaCO2 to rise

to the worsening gas exchange at this low level of workcontributedto the worsening gas exchange at this low level of work

B.(passive) Is chiefly caused byB.

to arterial desaturationcontributingto arterial desaturation

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