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Qaagi - Book of Why

Causes

Effects

AI A transgenic insertioncausingcryptorchidism in mice

P. L. Fox , ( 2017 ) EPRS ... a critical mTORC1-S6K1 effectorinfluencesadiposity in mice

The Journal of experimental medicinePD-1 and LAG-3 inhibitory co - receptors act synergisticallyto preventautoimmunity in mice

Data showcauseshypertriglyceridemia in mice

their vaccinepreventsleishmaniasis in mice

Fish oil supplements ( 1,000 mg capsule , 1 to 2 times per day ) , which are high in omega-3 fatty acids ... to helppreventamyloidosis in mice

using orally administered compoundto preventneurodegeneration in mice

introducing the cDNA for the enzyme , linked to the human alpha - skeletal actin gene promoter , into their germ line MuscleGenes as seen at the Olympia in Las Vegas 2013(passive) were created byPEPCK - Cmus mice

Proc Natl Acad Sci U S A ( 2008 ) 1.84 PD-1 and LAG-3 inhibitory co - receptors act synergisticallyto preventautoimmunity in mice

DDK ] Absence of Dpy19l2 , a new inner nuclear membrane proteincausesglobozoospermia in mice

1988429 EPRS ... a critical mTORC1-S6K1 effectorinfluencesadiposity in mice

T1 - EPRS ... a critical mTORC1-S6K1 effectorinfluencesadiposity in mice

Full Text Absence of Dpy19l2 , a new inner nuclear membrane proteincausesglobozoospermia in mice

In J Exp Med , 2011 LAG-3 acts synergistically with PD-1 and/or other immunoregulatory genesto preventautoimmunity in mice

Okazaki I , Wang J , Sugiura D , Nakaki F , Yoshida T , Kato Y , Fagarasan S , Muramatsu M , Eto T , Hioki K , Honjo T : PD-1 and LAG-3 inhibitory co - receptors act synergisticallyto preventautoimmunity in mice

this D776 mutationcould causeneurodegeneration in mice

a new mutationcausinghypermuscularity in mice

NSE ... sufficientto preventARHL in mice

handle/10919/79723 Quaternary ammonium disinfectantscausesubfertility in mice

| Sigma - Aldrich Development ( Cambridge , England ) 2012 - 7 - 6 Absence of Dpy19l2 , a new inner nuclear membrane proteincausesglobozoospermia in mice

a Kit gene missense mutation [ J(passive) caused byKitW-2Bao mice

Probable C - mannosyltransferase DPY19L2 J:187630 Pierre V , et al . , Absence of Dpy19l2 , a new inner nuclear membrane proteincausesglobozoospermia in mice

Nature 542 , 357–361 Rights & permissionsfor article EPRS ... a critical mTORC1–S6K1 effectorinfluencesadiposity in mice

Pierre V , Martinez G , Coutton C , Delaroche J , Yassine S , Novella C. Absence of Dpy19l2 , a new inner nuclear membrane proteincausesglobozoospermia in mice

Vita - Salute San Raffaele University Italy - 140.7 17 University of Innsbruck Austria - 140.4 4 Kyoto University Japan - 139.5 14 National Institute of Environmental Health Sciences USA $ 5,480,958.00 PD-1 and LAG-3 inhibitory co - receptors act synergisticallyto preventautoimmunity in mice

Sand Fly SalivaPreventsLeishmaniasis in Mice

the Axin2 gene and the mutationscausecraniosynostosis in mice

targeted gene disruption(passive) created byBLR1−/− mice

ablation of the GHRH genecausesIGHD in mice

homolog of mouse Listerin , whose mutation has been reportedto causeneurodegeneration in mice

trans fats have been shownto causesteatohepatitis in mice

noise - induced tinnitus and drugcan preventitexposed mice

Latchman Y. , Wood C.R. , Chernova T. , Chaudhary D. , Borde M. , Chernova I. , Iwai Y. , Long A.J. , Brown J.A. , Nunes R. , Greenfield E.A. , Bourque K. , Boussiotis V.A. , Carter L.L. , Carreno B.M. , Malenkovich N. , Nishimura H. , Okazaki T. , Honjo T. , Sharpe A.H. , Freeman G.J. " PD-1 and LAG-3 inhibitory co - receptors act synergisticallyto preventautoimmunity in mice

Yes , the paper dealt with mice cells , though injected human iPS cellscauseteratomas in mice

a homozygous truncation mutation in Trak1causeshypertonia in mice

mutations in another gene , lrdcan causeheterotaxy in mice

heterozygous loss of AQP0 ... sufficientto triggercataractogenesis in mice

Markers of UPR activation ... sufficientto causeFLD in mice

25 ppm NO2 ... sufficientto causeAHR in mice

ScholarKomatsu M , Waguri S , Chiba T , Murata S , Iwata J , Tanida I , Ueno T , Koike M , Uchiyama Y , Kominami E , Tanaka K : Loss of autophagy in the central nervous systemcausesneurodegeneration in mice

mitochondrial vacuolization , axonal degeneration , and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1.[Neurobiol Dis .causesmitochondrial vacuolization , axonal degeneration , and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1.[Neurobiol Dis .

Experimental pneumonitis and encephalitis(passive) caused byExperimental pneumonitis and encephalitis

mitochondrial vacuolization , axonal degeneration , and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1.Jaarsma D , Haasdijk ED , Grashorn JA , Hawkins R , van Duijn W , Verspaget HW , London Jcausesmitochondrial vacuolization , axonal degeneration , and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1.Jaarsma D , Haasdijk ED , Grashorn JA , Hawkins R , van Duijn W , Verspaget HW , London J

in significantly increased RNA expression of CD44 postoperatively [ 41resultedin significantly increased RNA expression of CD44 postoperatively [ 41

2012 ) Effects of RNA Interference - Induced Smad3 Gene Silencing on Pulmonary Fibrosis(passive) Caused by2012 ) Effects of RNA Interference - Induced Smad3 Gene Silencing on Pulmonary Fibrosis

acute pancreatitis(passive) caused byacute pancreatitis

weight loss without diet or exercisecausesweight loss without diet or exercise

to elevated FST immobility from around 10 - 18 times post surgery in comparison to sham - operated females ... find also the outcomes of Galea et alledto elevated FST immobility from around 10 - 18 times post surgery in comparison to sham - operated females ... find also the outcomes of Galea et al

severe immunodeficiency ( 19causessevere immunodeficiency ( 19

severe immunodeficiency ( 15causessevere immunodeficiency ( 15

to thymic tumorsleadsto thymic tumors

mammary tumorscausedmammary tumors

rescued PAMAM dendrimer - induced cell death and ameliorated acute lung injury(passive) caused byrescued PAMAM dendrimer - induced cell death and ameliorated acute lung injury

Enhanced motor performance and striatal dopamine transmission(passive) caused byEnhanced motor performance and striatal dopamine transmission

Over - expression of TSPO in the hippocampal CA1 area alleviates cognitive dysfunction(passive) caused byOver - expression of TSPO in the hippocampal CA1 area alleviates cognitive dysfunction

in up - regulation of GSH reductase , GSH peroxidase and glutamate cysteine ligase mRNA expression in muscleresultedin up - regulation of GSH reductase , GSH peroxidase and glutamate cysteine ligase mRNA expression in muscle

to reproducible extra - osseous tumorsledto reproducible extra - osseous tumors

from loss of functional selenoprotein P or its receptor apolipoprotein E receptor 2 Department of Pathology , Division of Gastroenterology , Hepatology and Nutrition , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 0252resultingfrom loss of functional selenoprotein P or its receptor apolipoprotein E receptor 2 Department of Pathology , Division of Gastroenterology , Hepatology and Nutrition , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 0252

all three cardiovascular responses : HR , MAP , and myocardial contractilityinfluenceall three cardiovascular responses : HR , MAP , and myocardial contractility

suppressed collagen expression in myositis(passive) caused bysuppressed collagen expression in myositis

to late embryonic lethality ( Jurado et al . , 2010leadto late embryonic lethality ( Jurado et al . , 2010

to developmental abnormalities including dwarfism , anophthalmia and 80 % embryonic lethalityledto developmental abnormalities including dwarfism , anophthalmia and 80 % embryonic lethality

neonatal lethality with skin abnormalities reminiscent of psoriatic lesions in humans ( 17causesneonatal lethality with skin abnormalities reminiscent of psoriatic lesions in humans ( 17

to a hypermuscular phenotype biomedcentral.com/bmcgenomics/article/10.1186/1471/2164/13/541 Monestier O Passet B Malhouroux M Magnol Lleads mainlyto a hypermuscular phenotype biomedcentral.com/bmcgenomics/article/10.1186/1471/2164/13/541 Monestier O Passet B Malhouroux M Magnol L

Golgi stress , apoptosis , and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotescausesGolgi stress , apoptosis , and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotes

a change in the strength of serotonin actions , specifically in brain circuits that impact the activation of movement and the ability to shake off drug memoriestriggereda change in the strength of serotonin actions , specifically in brain circuits that impact the activation of movement and the ability to shake off drug memories

hepatotoxicity(passive) provoked byhepatotoxicity

more sensitive than control animals ... showing more severe behavioural phenotype , astrogliosis and microgliosis in the neocortex and also a higher number of neurons with abnormal morphological featuresresultedmore sensitive than control animals ... showing more severe behavioural phenotype , astrogliosis and microgliosis in the neocortex and also a higher number of neurons with abnormal morphological features

to an enhanced expression of hepatic TIMP-1ledto an enhanced expression of hepatic TIMP-1

the itching(passive) caused bythe itching

microcephaly(passive) caused bymicrocephaly

in impaired proliferationresultedin impaired proliferation

neuroinflammation(passive) caused byneuroinflammation

the antidepressant - like effect(passive) caused bythe antidepressant - like effect

in lisinopril accuracy perfusionmay resultin lisinopril accuracy perfusion

Molecular Mechanism of Developmental Toxicity(passive) Caused byMolecular Mechanism of Developmental Toxicity

various organ - specific autoimmune diseases , such as gastritis , thyroiditis , and orchitis , ... the extent of lymphoid irradiation , and the genetic background of the mouse strainscausedvarious organ - specific autoimmune diseases , such as gastritis , thyroiditis , and orchitis , ... the extent of lymphoid irradiation , and the genetic background of the mouse strains

to both hepatic and intestinal injuries which are precisely interrelatedleadsto both hepatic and intestinal injuries which are precisely interrelated

hepatic porphyria and injury(passive) caused byhepatic porphyria and injury

increased susceptibility to mesenchymal and epithelial carcinogenesis in the models of 3-Methylcholanthrene ( 3-MCA)-induced carcinogenesis , and 7,12-dimethylbenz [ α ] anthracene / terephthalic acid ( DMBA / TPA)-induced skin carcinogenesis ( Figure 4causedincreased susceptibility to mesenchymal and epithelial carcinogenesis in the models of 3-Methylcholanthrene ( 3-MCA)-induced carcinogenesis , and 7,12-dimethylbenz [ α ] anthracene / terephthalic acid ( DMBA / TPA)-induced skin carcinogenesis ( Figure 4

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