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Qaagi - Book of Why

Causes

Effects

a mutation in stoned ( Fig . 7 C(passive) is caused bydelayed vesicle internalization

third space fluid accumulation ( i.e. , ascites , pleural effusion ) , renal insufficiency , inadequate hydration or administration of non - steroidal anti - inflammatory drugs or salicylates(passive) may be caused byDelayed methotrexate excretion

Accumulation of MTX within pleural , peritoneal , or cardiac effusionshas ledto delayed excretion

I takecausingdelayed excretion

renal functioncausingdelayed renal excretion

high - dose methotrexateresultingin delayed excretion

Urinary obstru­ctioncausesdelayed excretion

the accumulated toxicity and generate irreversible deterioration to the prognosis of the diseasemay causethe accumulated toxicity and generate irreversible deterioration to the prognosis of the disease

to decreased salicy late plasma concentrationleadingto decreased salicy late plasma concentration

to increase time for ammonia to be absorbed back into circulationcan leadto increase time for ammonia to be absorbed back into circulation

to SUDDEN releaseleadsto SUDDEN release

in gastroparesisresultingin gastroparesis

from prolonged parenchymal transit timeresultingfrom prolonged parenchymal transit time

to abdominal bloating or swollen anklesleadingto abdominal bloating or swollen ankles

to increased drug exposureleadingto increased drug exposure

increased uptake on bone scancould causeincreased uptake on bone scan

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