a mutation in stoned ( Fig . 7 C(passive) is caused bydelayed vesicle internalization
third space fluid accumulation ( i.e. , ascites , pleural effusion ) , renal insufficiency , inadequate hydration or administration of non - steroidal anti - inflammatory drugs or salicylates(passive) may be caused byDelayed methotrexate excretion
Accumulation of MTX within pleural , peritoneal , or cardiac effusionshas ledto delayed excretion
I takecausingdelayed excretion
renal functioncausingdelayed renal excretion
high - dose methotrexateresultingin delayed excretion
Urinary obstructioncausesdelayed excretion
the accumulated toxicity and generate irreversible deterioration to the prognosis of the diseasemay causethe accumulated toxicity and generate irreversible deterioration to the prognosis of the disease
to decreased salicy late plasma concentrationleadingto decreased salicy late plasma concentration
to increase time for ammonia to be absorbed back into circulationcan leadto increase time for ammonia to be absorbed back into circulation
to SUDDEN releaseleadsto SUDDEN release
in gastroparesisresultingin gastroparesis
from prolonged parenchymal transit timeresultingfrom prolonged parenchymal transit time
to abdominal bloating or swollen anklesleadingto abdominal bloating or swollen ankles
to increased drug exposureleadingto increased drug exposure
increased uptake on bone scancould causeincreased uptake on bone scan