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Smart Reasoning:

C&E

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Qaagi - Book of Why

Causes

Effects

the kidneysleadsto a decrease in creatinine clearance and proteinuria

cisplatincausesnephrotoxicity and reduced creatinine clearance

Other conditions , such as heart failure and dehydrationcan also causelow creatinine clearance levels

other drugscauseCREATININE RENAL CLEARANCE INCREASED

DrugscausedCreatinine Renal Clearance Increased

any drugcausingCREATININE RENAL CLEARANCE INCREASED

the glomerular damage(passive) could be caused byLow Creatinine Clearance Rate

FUROSEMIDE ... other drugscauseCREATININE RENAL CLEARANCE INCREASED

LASIX ... other drugscauseCREATININE RENAL CLEARANCE INCREASED

PREDNISOLONE ... other drugscauseCREATININE RENAL CLEARANCE INCREASED

PREDNISONE ... other drugscauseCREATININE RENAL CLEARANCE INCREASED

not CISPLATINcausesCREATININE RENAL CLEARANCE INCREASED

This increasemay resultfrom a decrease in renal clearance of digoxin

other drugscauseCREATININE RENAL CLEARANCE DECREASED

any drugcausingCREATININE RENAL CLEARANCE DECREASED

FUROSEMIDE ... other drugscauseCREATININE RENAL CLEARANCE DECREASED

PREDNISONE ... other drugscauseCREATININE RENAL CLEARANCE DECREASED

LASIX ... other drugscauseCREATININE RENAL CLEARANCE DECREASED

a possibilitycould causeCreatinine Renal Clearance Decreased

not CISPLATINcausesCREATININE RENAL CLEARANCE DECREASED

On the other hand , the pre - conditioning with diosmin and hesperidin in animals treated with Amp - B showed a significant reduction in the creatinine serum levelsresultingin increased clearance of creatinine ( p<0.05

many factors(passive) can be caused byDecreased creatinine levels

in turncausesincreased creatinine clearance

P - glycoproteinleadsto decreased renal clearance of digoxin

Exercisemay causeincreased creatinine clearance

Exercisemay causeincreased creatinine clearance

which is believedto resultin reduced renal clearance

Increase in GFRcausesdecrease in serum creatinine

3],[4may contributeReduced renal clearance

a major factorcausinga decrease in serum creatinine

a possible mechanismleadingto decreased cisplatin and creatinine clearance

by amphotericin B(passive) caused byDecreased renal clearance

Conditionscausingdecreased clearance of bilirubin

the renal proximal tubulesresultingin a reduction in creatinine clearance

by amphotericin B , foscarnet(passive) caused byDecreased renal clearance

For example , with age , the overall kidney size decreases and the number of glomeruli , which are the functional units of the kidney decreasesleadingto decrease in creatinine clearance

Other conditions , such as heart failure and dehydrationcan also causelow creatinine clearance

Elevated polyclonal sFLC concentrationsmay resultfrom decreased renal clearance

age - related decline in renal functioncan causea decrease of creatinine clearance

by amphotericin B , foscarnet , and aminoglycosides(passive) caused byDecreased renal clearance

to cancermay leadto cancer

UNBS5162could resultUNBS5162

alsomay resultalso

in diminished clearance of the drugwill resultin diminished clearance of the drug

accumulation of for examplecausesaccumulation of for example

to an increase in kidney functionleadingto an increase in kidney function

to an increase in the kidney functionleadingto an increase in the kidney function

to increased risk of lactic acidosiscould leadto increased risk of lactic acidosis

to an increased risk of toxic effectsmay leadto an increased risk of toxic effects

to a higher plasma concentration of uric acidleadsto a higher plasma concentration of uric acid

to an increase of these serum cytokines in cases of hemorrhagemay also leadto an increase of these serum cytokines in cases of hemorrhage

in an accumulation of anti - bacterial mediacations to toxic ( deadly ) levelswill resultin an accumulation of anti - bacterial mediacations to toxic ( deadly ) levels

to delayed recoverymay contributeto delayed recovery

to delayed recoverymay contributeto delayed recovery

to increased toxicitymay leadto increased toxicity

Half - lives(passive) can be influenced byHalf - lives

to decreased toxicitymay leadto decreased toxicity

to increased risk of toxic effectmay leadto increased risk of toxic effect

to eventsmay leadto events

to increased toxicity , Digoxin , Digoxin 0may leadto increased toxicity , Digoxin , Digoxin 0

to confusionmay leadto confusion

the increase of creatinine(passive) is caused bythe increase of creatinine

the increase of creatinine(passive) is causedthe increase of creatinine

to increased risk of toxic effectsmay leadto increased risk of toxic effects

to the effectalso contributedto the effect

Increased serum creatinine levels(passive) may be caused byIncreased serum creatinine levels

from conditions such as cardiovascular collapse ( shock ) , acute myocardial infarction , and septicaemiamay ... resultfrom conditions such as cardiovascular collapse ( shock ) , acute myocardial infarction , and septicaemia

them to end - stage renal failureleadsthem to end - stage renal failure

from shock , septicemia , or myocardial infarctionresultingfrom shock , septicemia , or myocardial infarction

to mucous membrane lesions and ligneous conjunctivitisleadingto mucous membrane lesions and ligneous conjunctivitis

to increased therapeutic effects and side effectsleadsto increased therapeutic effects and side effects

in renal insufficiency noted on Day 1resultingin renal insufficiency noted on Day 1

drug accumulationcausingdrug accumulation

substantial increases in serum digoxincausingsubstantial increases in serum digoxin

only about 10 %contributesonly about 10 %

to increased lithium serum concentration , which leads to additional decreases in lithium clearance and so onleadingto increased lithium serum concentration , which leads to additional decreases in lithium clearance and so on

to improve pharmacokineticsthus leadingto improve pharmacokinetics

in a soluble forresultingin a soluble for

in no need to modify dosageresultingin no need to modify dosage

in unspecific tubular absorption of radiolabelled peptidescan resultin unspecific tubular absorption of radiolabelled peptides

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Smart Reasoning:

C&E

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