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Qaagi - Book of Why

Causes

Effects

by NO binding(passive) caused bythe inhibition ... to Cox

aspirincausingirreversible COX inhibition

by NSAIDs(passive) caused bythe inhibition of cyclooxygenase ( COX

by their use(passive) caused bythe COX inhibition

their use(passive) caused bythe COX inhibition

to reduced PGE2 production which occurs with aspirin therapyleadingto reduced PGE2 production which occurs with aspirin therapy

to decreased sodium excretion and increased sodium retentioncan leadto decreased sodium excretion and increased sodium retention

alsoresultedalso

to platelet aggregationleadsto platelet aggregation

in reduced generation of prostaglandinsresultingin reduced generation of prostaglandins

to renal dysfunction and blood pressure elevation , but may precipitate heart failure in vulnerable individuals ( 20 , 21 , 24 , 25can ... leadto renal dysfunction and blood pressure elevation , but may precipitate heart failure in vulnerable individuals ( 20 , 21 , 24 , 25

differential effects on kynurenine metabolismprovokesdifferential effects on kynurenine metabolism

the nurse cell dumping defects(passive) caused bythe nurse cell dumping defects

gastrointestinal [ 20can causegastrointestinal [ 20

gastrointestinalcan causegastrointestinal

gastrointestinal [ 20 ] and cardiovascular side effects.[21can causegastrointestinal [ 20 ] and cardiovascular side effects.[21

The decrease in renal prostaglandin synthesis(passive) caused byThe decrease in renal prostaglandin synthesis

to reduced prostaglandins leading to reduced renal blood flowleadingto reduced prostaglandins leading to reduced renal blood flow

gastrointestinal [ 20 ] andcan causegastrointestinal [ 20 ] and

alsocausesalso

the dumping defects(passive) caused bythe dumping defects

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