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Qaagi - Book of Why

Causes

Effects

attention ... an anti - cancer compoundto preventtumor growth , angiogenesis , and metastasis

In tumors , cross talk between malignant and non - malignant cells ( stromainfluencestumor growth , angiogenesis and metastasis

DNA fragmentationthereby preventingangiogenesis and tumor growth

myeloid cell invasion ... tumorspreventstumor growth , angiogenesis and metastasis

MET receptor mutations are associated with poor prognosiscan triggertumor growth , angiogenesis and metastasis

MET mutation is associated with a poor prognosiscan triggertumor growth , angiogenesis and metastasis

Mutations of MET gene are associated with a poor prognosistriggertumor growth , angiogenesis and metastases

c - MET mutation is linked with a poor prognosiscan triggertumor growth , angiogenesis and metastasis

MABp1 targets and binds to IL-1αpreventingIL-1α - mediated tumor growth , metastasis , and invasiveness

C - MET signaling regulate various cellular functions including cell proliferation , survival and apoptosis , and abnormal activation of c - MET kinasemay triggertumor growth , angiogenesis and metastasis

Vessel leakiness ... tumor vesselsinfluencesangiogenesis , tumor growth , and metastasis

immune response(passive) caused byimmune response

new opportunities in the fight against cancerhas creatednew opportunities in the fight against cancer

cachexiapreventingcachexia

to cancer progressionleadingto cancer progression

to decreased survivalleadsto decreased survival

COX-2–PGE2-induced angiogenesisto preventCOX-2–PGE2-induced angiogenesis

in poor survival in a mouse modelresultingin poor survival in a mouse model

to visual loss(2may leadto visual loss(2

in poor prognosisresultingin poor prognosis

such a large tumor burden that the host succumbscreatesuch a large tumor burden that the host succumbs

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