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unrestricted complement activitycausingcomplement deficiency
PNH ... the PIG - A generesultsin deficiency of complement
complement component deficiency and ( b ) carriers of heterozygous mutationcausingcomplement component deficiency
no proven strategiesto preventautodegradation of complement deficiency
e.g. encapsulated bacteriamay leadDeficiency in complement system
It is important from birthto preventautodegradation of complement deficiency
molecular mechanismsleadingto complement deficiency
not doing many of the things above , and to bring our bodies back to homeostasis ( natural , balanced healthy state(passive) is caused byEndocannabinoid System deficiency
a novel mutationleadingto a complement deficiency
in immunologists(passive) was discoveredComplement deficiency
to the autoimmune disease , systemic lupus erythematosus ( SLEcontributesto the autoimmune disease , systemic lupus erythematosus ( SLE
to impaired handling of immune complex and inadequate clearance apoptotic cell debris [ 11 , 12leadsto impaired handling of immune complex and inadequate clearance apoptotic cell debris [ 11 , 12
impaired clearance of these immune complexeslikewise causesimpaired clearance of these immune complexes
incomplete maintenance of peripheral tolerancecausesincomplete maintenance of peripheral tolerance
from the lack of C1 esterase inhibitorresultingfrom the lack of C1 esterase inhibitor
SLE by impairment of the physiological clearance of apoptotic cells by macrophagescausesSLE by impairment of the physiological clearance of apoptotic cells by macrophages
to increased susceptibilitymay leadto increased susceptibility
in accumulation of functional autoreactive cells ... possibly leading to autoimmunitycould resultin accumulation of functional autoreactive cells ... possibly leading to autoimmunity
SLE ... and yet SLE causes activation and consumption of complementcausesSLE ... and yet SLE causes activation and consumption of complement
severe recurrent bacterialcan causesevere recurrent bacterial
to autoimmune disorders and impairs tissue regenerationleadsto autoimmune disorders and impairs tissue regeneration
to life - threatening infections as well as long term autoimmune conditions and organ injuriescan leadto life - threatening infections as well as long term autoimmune conditions and organ injuries
lupus is hard to reconcile with the concept that complement activation products are the major cause of inflammatory injury in the diseasecauseslupus is hard to reconcile with the concept that complement activation products are the major cause of inflammatory injury in the disease
an individual ’s susceptibility to mold exposurewould influencean individual ’s susceptibility to mold exposure
immune complex diseases(passive) caused byimmune complex diseases
a genetic predisposition to becoming an immunologistcausesa genetic predisposition to becoming an immunologist