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Igg igm antibodies and complement cell bound host cells with foreign antigen drug actingcausesone complement activation
This reduction ... seems alsoto causedsignificant complement activation
by anti - CFH antibodies(passive) influenced bythe state of complement activation
the pathwaysleadingcomplement activation giving examples of
the antibodycausingcomplement activation in AIHA
The rashcould resultconsequence complement activation
anti - RBC IgMcausescomplement activation in AIHA
Genetic defectscausinguncontrolled complement activation
DSAs.6,12(passive) caused byuncontrolled complement activation
DSAs.1,2(passive) caused byuncontrolled complement activation
the endresultthis complement activation complement fixation
Immune complex deposition ... ( immune complex - mediated ) and dysregulation and persistent activation of the alternative complement pathwayleadingto activation of complement
An immune complex ... binding to antigencan resultin activation of complement
Factor H protects host cells from injuryresultingfrom unrestrained complement activation
Immune complexes as well as autoantibodies bound to antigens on cellscausecomplement activation
mutations or autoantibodiesleadingto dysregulated complement activation
immune complex formation ( 1resultsin complement activation
Antigen - antibody immune complex depositioncausingcomplement activation
Addition of patient serum containing mutant factor H to control plateletsresultedin complement activation
complement regulatory proteinsresultingin complement activation
Specific binding of l - ficolin and h - ficolin to apoptotic cellsleadsto complement activation
The advantages ... histone proteinscontributeto extravascular complement activation
The binding of antibodiesresultsin complement activation
While Factor H deficiency inducescausescomplement activation
Factor H deficiency induces /causescomplement activation
This antibody - antigen interactioncan causecomplement activation
ANCA - induced activation of ... factorscausecomplement activation
Antibody - antigen complexescauseactivation of complement
an important family of pattern recognition moleculescontributesto complement activation
the antibody titer ... too low ... or when the antibody does not activate complement or when the antigen for which the antibody is specific is expressed only at very low levels on the donor 's lymphocytesto causecomplement activation
Immune complex depositioncausescomplement activation
Immune complex depositionmay leadto complement activation
Immune complex depositionleadingto activation of complement
The deposition of immune complexresultedin activation of the complement
the key downstream proteinsresultingfrom complement activation
depletion of Factor H in plasmaresultedin complement activation
Three pathwaysleadcomplement activation
Immune complexescan causeactivation of complement
immune complexesleadto complement activation
the injection of human anti - THSD7A antibody in serumcausescomplement activation
to target cell chemotaxis , cellular activation , lysis , or apoptosisleadsto target cell chemotaxis , cellular activation , lysis , or apoptosis
inflammatory injurycausedinflammatory injury
alsoresultsalso
to an important local inflammatory stateto contributeto an important local inflammatory state
damage or apoptosiscausingdamage or apoptosis
onset and progression of numerous inflammatory diseasescan causeonset and progression of numerous inflammatory diseases
the release of histamine and other mediators of immediate hypersensitivity from basophils and mast cellscausesthe release of histamine and other mediators of immediate hypersensitivity from basophils and mast cells
in vasodilatation and inflammationresultsin vasodilatation and inflammation
further systemic mediator productioncausesfurther systemic mediator production
to RPE pathology in AMDcontributeto RPE pathology in AMD
to anaphylaxisleadingto anaphylaxis
to the generation of C3 cleavage fragments or the formation of membrane attack complexleadingto the generation of C3 cleavage fragments or the formation of membrane attack complex
in MAC formationresultingin MAC formation
direct injury to the host cells as well as induce potent inflammation and phagocytic destruction of host tissuecan causedirect injury to the host cells as well as induce potent inflammation and phagocytic destruction of host tissue
to tissue deposition of activated complement components and release of pro - inflammatory factorsleadsto tissue deposition of activated complement components and release of pro - inflammatory factors
to tissue damage through activation of the membrane attack complex ( C5 - 9leadsto tissue damage through activation of the membrane attack complex ( C5 - 9
crises in Systemic Lupus Erythematosus(passive) are provoked bycrises in Systemic Lupus Erythematosus
to target cell death opsonization and membrane attack complexleadsto target cell death opsonization and membrane attack complex
to formation of the membrane attack complex ( MACleadsto formation of the membrane attack complex ( MAC
damage to host cells alsocan causedamage to host cells also
to the development of the membrane attack complexleadsto the development of the membrane attack complex
in immune adherence and phagocytosis , local inflammation and cell lysiscan resultin immune adherence and phagocytosis , local inflammation and cell lysis
to complement - mediated cell lysiscan leadto complement - mediated cell lysis
to cleavage and deposition of C3 and C5 activation productsleadsto cleavage and deposition of C3 and C5 activation products
to cellular activation and cell deathleadsto cellular activation and cell death
in cell lysis and inflammationresultingin cell lysis and inflammation
to the generation of a series of activation peptides that are capable of producing inflammationalso leadsto the generation of a series of activation peptides that are capable of producing inflammation
Damage to the Host CellsCausedDamage to the Host Cells
inflammation and further activation of the immune systemcausesinflammation and further activation of the immune system
to the generation of many potent effectors including anaphylatoxin C5a [ 4 ] , which is important for leukocyte recruitment and activation [ 5leadsto the generation of many potent effectors including anaphylatoxin C5a [ 4 ] , which is important for leukocyte recruitment and activation [ 5
to direct lysis of bacteria through assembly of membrane attack complexescan also leadto direct lysis of bacteria through assembly of membrane attack complexes
from immune complex generationresultingfrom immune complex generation
in the formation of anaphylatoxins , including the biologically active protein C5aadditionally resultsin the formation of anaphylatoxins , including the biologically active protein C5a
in intravascular hemolysisresultingin intravascular hemolysis
the deposition of lytic complement components on nearby host cells as well as on microbial targets ... resulting in host cell lysismay causethe deposition of lytic complement components on nearby host cells as well as on microbial targets ... resulting in host cell lysis
to cells destructionmay leadto cells destruction
to cleavage of complement component 3 ( C3leadsto cleavage of complement component 3 ( C3
to the injury and outcome of kidney in human anti - glomerular basement membrane diseasecontributesto the injury and outcome of kidney in human anti - glomerular basement membrane disease
to allograft injury in several clinical settings , including ischemia / reperfusion injury and antibody mediated rejectioncontributesto allograft injury in several clinical settings , including ischemia / reperfusion injury and antibody mediated rejection
to cell lysisleadingto cell lysis