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Igg igm antibodies and complement cell bound host cells with foreign antigen drug actingcausesone complement activation
by anti - CFH antibodies(passive) influenced bythe state of complement activation
Deficiency of regulatory proteins results in excessive complement activation ... Complement systemcausesComplement activation pathways
the antibodycausingcomplement activation in AIHA
anti - RBC IgMcausescomplement activation in AIHA
Genetic defectscausinguncontrolled complement activation
DSAs.6,12(passive) caused byuncontrolled complement activation
Immune complex deposition ... ( immune complex - mediated ) and dysregulation and persistent activation of the alternative complement pathwayleadingto activation of complement
liposomes , micellar carriers of intravenous drugs , and radiocontrast agents(passive) caused byComplement activation - related pseudoallergy
various effector functions such as Fc - receptor binding and complement component C1q bindingleadsto complement activation
Binding of antibodies to self proteinsleadsto complement activation
Binding of antibodies to proteinsleadsto complement activation
Immune complexes as well as autoantibodies bound to antigens on cellscausecomplement activation
mutations or autoantibodiesleadingto dysregulated complement activation
immune complex formation ( 1resultsin complement activation
Antigen - antibody immune complex depositioncausingcomplement activation
Addition of patient serum containing mutant factor H to control plateletsresultedin complement activation
complement regulatory proteinsresultingin complement activation
Specific binding of L - ficolin and H - ficolin to apoptotic cellsleadsto complement activation
The advantages ... histone proteinscontributeto extravascular complement activation
The binding of antibodiesresultsin complement activation
Generation of virus - antibody immune complexesleadingto complement activation
While Factor H deficiency inducescausescomplement activation
Factor H deficiency induces /causescomplement activation
This antibody - antigen interactioncan causecomplement activation
ANCA - induced activation of ... factorscausecomplement activation
Antibody - antigen complexescauseactivation of complement
an important family of pattern recognition moleculescontributesto complement activation
the antibody titer ... too low ... or when the antibody does not activate complement or when the antigen for which the antibody is specific is expressed only at very low levels on the donor 's lymphocytesto causecomplement activation
Immune complex depositioncausescomplement activation
Immune complex depositionleadingto activation of complement
immune complex depositionleadingto complement activation
Immune complex depositionmay leadto complement activation
the key downstream proteinsresultingfrom complement activation
One mechanismmay leadto complement activation
three pathways ... : the classic , alternative , and lectin pathwaysleadto complement activation
depletion of Factor H in plasmaresultedin complement activation
Antibody - antigen interactionscan leadto complement activation
Three pathwaysleadcomplement activation
their activation fragmentsleadingto complement activation
to the pathogenesis of AMDmay ... contributeto the pathogenesis of AMD
damage or apoptosiscausingdamage or apoptosis
the release of histamine and other mediators of immediate hypersensitivity from basophils and mast cellscausesthe release of histamine and other mediators of immediate hypersensitivity from basophils and mast cells
in vasodilatation and inflammationresultsin vasodilatation and inflammation
to RPE pathology in AMDcontributeto RPE pathology in AMD
to the generation of C3 cleavage fragments or the formation of membrane attack complexleadingto the generation of C3 cleavage fragments or the formation of membrane attack complex
in MAC formationresultingin MAC formation
direct injury to the host cells as well as induce potent inflammation and phagocytic destruction of host tissuecan causedirect injury to the host cells as well as induce potent inflammation and phagocytic destruction of host tissue
to tissue deposition of activated complement components and release of pro - inflammatory factorsleadsto tissue deposition of activated complement components and release of pro - inflammatory factors
to tissue damage through activation of the membrane attack complex ( C5 - 9leadsto tissue damage through activation of the membrane attack complex ( C5 - 9
crises in Systemic Lupus Erythematosus(passive) are provoked bycrises in Systemic Lupus Erythematosus
to target cell death opsonization and membrane attack complexleadsto target cell death opsonization and membrane attack complex
to formation of the membrane attack complex ( MACleadsto formation of the membrane attack complex ( MAC
to membrane attack complex ( MAC ) formationleadingto membrane attack complex ( MAC ) formation
damage to host cells alsocan causedamage to host cells also
to the development of the membrane attack complexleadsto the development of the membrane attack complex
in immune adherence and phagocytosis , local inflammation and cell lysiscan resultin immune adherence and phagocytosis , local inflammation and cell lysis
to complement - mediated cell lysiscan leadto complement - mediated cell lysis
to cleavage and deposition of C3 and C5 activation productsleadsto cleavage and deposition of C3 and C5 activation products
to cellular activation and cell deathleadsto cellular activation and cell death
in cell lysis and inflammationresultingin cell lysis and inflammation
to the generation of a series of activation peptides that are capable of producing inflammationalso leadsto the generation of a series of activation peptides that are capable of producing inflammation
Damage to the Host CellsCausedDamage to the Host Cells
to the production of the anaphylatoxins C3a and C5a and the membrane attack complexleadsto the production of the anaphylatoxins C3a and C5a and the membrane attack complex
to the generation of many potent effectors including anaphylatoxin C5a [ 4 ] , which is important for leukocyte recruitment and activation [ 5leadsto the generation of many potent effectors including anaphylatoxin C5a [ 4 ] , which is important for leukocyte recruitment and activation [ 5
to direct lysis of bacteria through assembly of membrane attack complexescan also leadto direct lysis of bacteria through assembly of membrane attack complexes
to membrane attack complexleadingto membrane attack complex
from immune complex generationresultingfrom immune complex generation
in the formation of anaphylatoxins , including the biologically active protein C5aadditionally resultsin the formation of anaphylatoxins , including the biologically active protein C5a
in intravascular hemolysisresultingin intravascular hemolysis
the deposition of lytic complement components on nearby host cells as well as on microbial targets ... resulting in host cell lysismay causethe deposition of lytic complement components on nearby host cells as well as on microbial targets ... resulting in host cell lysis
to both host defense as well as injurycan contributeto both host defense as well as injury
to cells destructionmay leadto cells destruction
to cleavage of complement component 3 ( C3leadsto cleavage of complement component 3 ( C3
to the injury and outcome of kidney in human anti - glomerular basement membrane diseasecontributesto the injury and outcome of kidney in human anti - glomerular basement membrane disease
to allograft injury in several clinical settings , including ischemia / reperfusion injury and antibody mediated rejectioncontributesto allograft injury in several clinical settings , including ischemia / reperfusion injury and antibody mediated rejection
to formation of deposit - associated terminal complement complexesleadingto formation of deposit - associated terminal complement complexes
to cell lysisleadingto cell lysis
the increased deposition of C3b on the cell surface of retinal cells ... , combined with the limited ability of cells to remove C3 activated fragments such as C3b(passive) caused bythe increased deposition of C3b on the cell surface of retinal cells ... , combined with the limited ability of cells to remove C3 activated fragments such as C3b
the deposition of lytic complement components on microbial targets as well as host cells nearbycausingthe deposition of lytic complement components on microbial targets as well as host cells nearby