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Qaagi - Book of Why

Causes

Effects

9 , 22 ] Apneamay resultin combined metabolic and respiratory acidosis

act metabolically as well ,creatinga combined respiratory and metabolic acidosis

cessation of pulmonary gas exchange and the development of anaerobic cellular metabolism respectively(passive) caused bycombined respiratory and metabolic acidosis

Kidneys and lungs are knownto causemetabolic and respiratory acidosis respectively

Rapid transfusion of bloodinitially causescombined respiratory and metabolic acidosis

As the patient is warmed , Co2 production increases and lactate is flushed from previously constricted vascular bedscausinga combined metabolic and respiratory acidosis

if kidneys functional ) decrease HCO3- synthesis decrease H+ excretion if severe , HCl infusion Respiratory failure that resulted in decrease delivery of oxygen to the tissues of the body and decreased removal of carbon dioxide from the bodycan resultin a combined metabolic and respiratory acidosis

a HIGH respiratory rateto preventcombined metabolic and respiratory acidosis

APPS THAT DO THE JOB : ABG ( free ) = input values for pH , pCO2 , HCO3 and pO2 to getresultmetabolic and respiratory acidosis

establish an airwayto preventmetabolic and respiratory acidosis

epinephrine in this model of local anesthetic toxicity(passive) caused bycombined respiratory and metabolic derangements

a metabolic acidosis secondary to lactic acidosis from systemic ischaemiaCausesa metabolic acidosis secondary to lactic acidosis from systemic ischaemia

to coma and deathleadingto coma and death

pulmonary vasoconstriction ... resulting in impaired endothelial and epithelial integrity with leakage of proteinaceous exudate and formation of hyaline membranes ( hence the namecausepulmonary vasoconstriction ... resulting in impaired endothelial and epithelial integrity with leakage of proteinaceous exudate and formation of hyaline membranes ( hence the name

muscle performance in different waysmay influencemuscle performance in different ways

to hyperkalemia due to the displacement of K+ from cells by H+can ... leadto hyperkalemia due to the displacement of K+ from cells by H+

in increased pulmonary vascular resistance preventing the increase of blood flow through the lungsresultsin increased pulmonary vascular resistance preventing the increase of blood flow through the lungs

increased activity of pH - dependent enzymes in glycolytic pathway that promotes lactate productioncausesincreased activity of pH - dependent enzymes in glycolytic pathway that promotes lactate production

to increased endogenous lactic acid productioncould leadto increased endogenous lactic acid production

albumin to liberate H+causesalbumin to liberate H+

decrease in ionized calciumcausedecrease in ionized calcium

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