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Qaagi - Book of Why

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7641):357 - 361 EPRS ... a critical mTORC1-S6K1 effectorinfluencesadiposity in mice

Okazaki T , Okazaki I , Wang J , Sugiura D , Nakaki F , Yoshida T , Kato Y , Fagarasan S , Muramatsu M , Eto T , Hioki K , Honjo T : PD-1 and LAG-3 inhibitory co - receptors act synergisticallyto preventautoimmunity in mice

P. L. Fox , ( 2017 ) EPRS ... a critical mTORC1-S6K1 effectorinfluencesadiposity in mice

The Journal of experimental medicinePD-1 and LAG-3 inhibitory co - receptors act synergisticallyto preventautoimmunity in mice

researchers ... a mutationcausescraniosynostosis in mice

AI A transgenic insertioncausingcryptorchidism in mice

Proc Natl Acad Sci U S A ( 2008 ) 1.84 PD-1 and LAG-3 inhibitory co - receptors act synergisticallyto preventautoimmunity in mice

T1 - EPRS ... a critical mTORC1-S6K1 effectorinfluencesadiposity in mice

1988429 EPRS ... a critical mTORC1-S6K1 effectorinfluencesadiposity in mice

using orally administered compoundto preventneurodegeneration in mice

Nature 542 , 357–361 Rights & permissionsfor article EPRS ... a critical mTORC1–S6K1 effectorinfluencesadiposity in mice

Fish oil supplements ( 1,000 mg capsule 1 - 2 times per day ) , which are high in omega-3 fatty acids ... to helppreventamyloidosis in mice

a previously - unknown , fully penetrant epistatic interaction between Pnpla2 and Lipe ( show LIPE Antibodiescan causeliposarcoma in mice

a previously - unknown , fully penetrant epistatic interaction between Pnpla2 and Lipe ( show LIPE ELISA Kitscan causeliposarcoma in mice

Vita - Salute San Raffaele University Italy - 140.7 17 University of Innsbruck Austria - 140.4 4 Kyoto University Japan - 139.5 14 National Institute of Environmental Health Sciences USA $ 5,480,958.00 PD-1 and LAG-3 inhibitory co - receptors act synergisticallyto preventautoimmunity in mice

In J Exp Med , 2011 LAG-3 acts synergistically with PD-1 and/or other immunoregulatory genesto preventautoimmunity in mice

Latchman Y. , Wood C.R. , Chernova T. , Chaudhary D. , Borde M. , Chernova I. , Iwai Y. , Long A.J. , Brown J.A. , Nunes R. , Greenfield E.A. , Bourque K. , Boussiotis V.A. , Carter L.L. , Carreno B.M. , Malenkovich N. , Nishimura H. , Okazaki T. , Honjo T. , Sharpe A.H. , Freeman G.J. " PD-1 and LAG-3 inhibitory co - receptors act synergisticallyto preventautoimmunity in mice

Knockout of this gene is reportedto causeparkinsonianism in mice

Hsu 's lab , including the study 's lead author , Takamitsu Maruyama , Ph.D. ... a mutationcausescraniosynostosis in mice

Almost 50 million Americans 's findings of a simple chemical compoundhelped preventNIHL in mice

a specific mutationcausescraniosynostosis in mice

a new mutationcausinghypermuscularity in mice

years ... a mutationcausescraniosynostosis in mice

this D776 mutationcould causeneurodegeneration in mice

Read More … Compoundpreventsneurodegeneration in mice

a single mutation of Tgif ... sufficientto causeholoprosencephaly in mice

The human COL2A1 gene with the Arg519Cys mutationcausesosteochondrodysplasia in mice

handle/10919/79723 Quaternary ammonium disinfectantscausesubfertility in mice

NSE ... sufficientto preventARHL in mice

loss - of - function of Atg genes ... sufficientto causeneurodegeneration in mice

A mutation in the PB2 gene , at position 627 , has been shownto influencepathogenicity in mice

homolog of mouse Listerin , whose mutation has been reportedto causeneurodegeneration in mice

Sand Fly SalivaPreventsLeishmaniasis in Mice

View at Google Scholar · View at ScopusY. Komatsu , P. B. Yu , N. Kamiya et al . , “ Augmentation of Smad - dependent BMP signaling in neural crest cells ... ” Journal of Bone and Mineral Research , 2012causescraniosynostosis in mice

circatidal pacemaker " Compoundpreventsneurodegeneration in mice

the Axin2 gene and the mutationscausecraniosynostosis in mice

ablation of the GHRH genecausesIGHD in mice

Yes , the paper dealt with mice cells , though injected human iPS cellscauseteratomas in mice

topical application of ( −)-epigallocatechin-3-gallate ( EGCG ) , the major polyphenol of green teapreventsphotocarcinogenesis in mice

a mutation in ITAM of TCR zetacausesautoimmunity in mice

Experimental pneumonitis and encephalitis(passive) caused byExperimental pneumonitis and encephalitis

14041164 Disturbance of Porphyrin Metabolism(passive) Caused by14041164 Disturbance of Porphyrin Metabolism

a centronuclear myopathy - like phenotype | Disease Models & Mechanisms Skipcausesa centronuclear myopathy - like phenotype | Disease Models & Mechanisms Skip

to a myopathy with a neurogenic component , Human Molecular Genetics , 2009 , 18 , 7 , 1353leadsto a myopathy with a neurogenic component , Human Molecular Genetics , 2009 , 18 , 7 , 1353

to spontaneous development on B cell lymphomaleadsto spontaneous development on B cell lymphoma

acute pancreatitis(passive) caused byacute pancreatitis

in significantly increased RNA expression of CD44 postoperatively [ 41resultedin significantly increased RNA expression of CD44 postoperatively [ 41

weight loss without diet or exercisecausesweight loss without diet or exercise

from loss of functional selenoprotein P or its receptor apolipoprotein E receptor 2 Department of Pathology , Division of Gastroenterology , Hepatology and Nutrition , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 0252resultingfrom loss of functional selenoprotein P or its receptor apolipoprotein E receptor 2 Department of Pathology , Division of Gastroenterology , Hepatology and Nutrition , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 0252

severe immunodeficiency ( 15causessevere immunodeficiency ( 15

severe immunodeficiency ( 19causessevere immunodeficiency ( 19

subgingival hair growth and an increased fraction of trabecular bone — NYU Scholars @article{4ae1c44ccd4748f99ea22922fb342a67causessubgingival hair growth and an increased fraction of trabecular bone — NYU Scholars @article{4ae1c44ccd4748f99ea22922fb342a67

to elevated FST immobility from around 10 - 18 times post surgery in comparison to sham - operated females ... find also the outcomes of Galea et alledto elevated FST immobility from around 10 - 18 times post surgery in comparison to sham - operated females ... find also the outcomes of Galea et al

to retinal degeneration and azoospermia AU - Kuoleadsto retinal degeneration and azoospermia AU - Kuo

to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavageleadsto persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage

rescued PAMAM dendrimer - induced cell death and ameliorated acute lung injury(passive) caused byrescued PAMAM dendrimer - induced cell death and ameliorated acute lung injury

to retinal degeneration and azoospermia ' , Human Molecular Geneticsleadsto retinal degeneration and azoospermia ' , Human Molecular Genetics

to late embryonic lethality ( Jurado et al . , 2010leadto late embryonic lethality ( Jurado et al . , 2010

bipolar disorder Researchers , led by Pann - Ghill Suh , a professor of life sciences at UNIST , genetically designed mice to have a deficiency of PLCγ1 in their forebraincausesbipolar disorder Researchers , led by Pann - Ghill Suh , a professor of life sciences at UNIST , genetically designed mice to have a deficiency of PLCγ1 in their forebrain

suppressed collagen expression in myositis(passive) caused bysuppressed collagen expression in myositis

all three cardiovascular responses : HR , MAP , and myocardial contractilityinfluenceall three cardiovascular responses : HR , MAP , and myocardial contractility

Over - expression of TSPO in the hippocampal CA1 area alleviates cognitive dysfunction(passive) caused byOver - expression of TSPO in the hippocampal CA1 area alleviates cognitive dysfunction

a centronuclear myopathy - like phenotype Val A. Fajardo , Eric Bombardier , Elliott McMillan , Khanh Tran , Brennan J. Wadsworth , Daniel Gamu , Andrew Hopf , Chris Vigna , Ian C. Smith , Catherine Bellissimo , Robin N. Michel , Mark A. Tarnopolsky , Joe Quadrilatero , A. Russell Tupling Disease Models & Mechanisms 2015 8 : 999 - 1009 ; doi : 10.1242 / dmm.020859 Citation Manager Formatscausesa centronuclear myopathy - like phenotype Val A. Fajardo , Eric Bombardier , Elliott McMillan , Khanh Tran , Brennan J. Wadsworth , Daniel Gamu , Andrew Hopf , Chris Vigna , Ian C. Smith , Catherine Bellissimo , Robin N. Michel , Mark A. Tarnopolsky , Joe Quadrilatero , A. Russell Tupling Disease Models & Mechanisms 2015 8 : 999 - 1009 ; doi : 10.1242 / dmm.020859 Citation Manager Formats

to age - related OA but no alteration of injury - induced OA ( Bouderlique et al . , 2016leadsto age - related OA but no alteration of injury - induced OA ( Bouderlique et al . , 2016

aberrant SFK activity and lethality during embryogenesis ( Imamoto and Soriano , 1993 ; Nada et al . , 1993causesaberrant SFK activity and lethality during embryogenesis ( Imamoto and Soriano , 1993 ; Nada et al . , 1993

subgingival hair growth and an increased fraction of trabecular bone Gamage , T. H. , Lengle , E. , Gunnes , G. , Pullisaar , H. , Holmgren , A. , Reseland , J. E. , Merckoll , E. , Corti , S. , Mizobuchi , M. , Morales , R. J. , Tsiokas , L. , Tjønnfjord , G. E. , Lacruz , R. S. , Lyngstadaas , S. P. , Misceo , D. & Frengen , E.causessubgingival hair growth and an increased fraction of trabecular bone Gamage , T. H. , Lengle , E. , Gunnes , G. , Pullisaar , H. , Holmgren , A. , Reseland , J. E. , Merckoll , E. , Corti , S. , Mizobuchi , M. , Morales , R. J. , Tsiokas , L. , Tjønnfjord , G. E. , Lacruz , R. S. , Lyngstadaas , S. P. , Misceo , D. & Frengen , E.

Golgi stress , apoptosis , and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotescausesGolgi stress , apoptosis , and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotes

subgingival hair growth and an increased fraction of trabecular bone — Italian Ministry of Health Thilini H. Gamage , Emma Lengle , Gjermund Gunnes , Helen Pullisaar , Asbjørn Holmgren , Janne E. Reseland , Else Merckoll , Stefania Corti , Masahiro Mizobuchi , Raul J. Morales , Leonidas Tsiokas , Geir E. Tjønnfjord , Rodrigo S. Lacruz , Staale P. Lyngstadaas , Doriana Misceocausessubgingival hair growth and an increased fraction of trabecular bone — Italian Ministry of Health Thilini H. Gamage , Emma Lengle , Gjermund Gunnes , Helen Pullisaar , Asbjørn Holmgren , Janne E. Reseland , Else Merckoll , Stefania Corti , Masahiro Mizobuchi , Raul J. Morales , Leonidas Tsiokas , Geir E. Tjønnfjord , Rodrigo S. Lacruz , Staale P. Lyngstadaas , Doriana Misceo

to a hypermuscular phenotype biomedcentral.com/bmcgenomics/article/10.1186/1471/2164/13/541 Monestier O Passet B Malhouroux M Magnol Lleads mainlyto a hypermuscular phenotype biomedcentral.com/bmcgenomics/article/10.1186/1471/2164/13/541 Monestier O Passet B Malhouroux M Magnol L

Parkinson ’s disease ( PD)-like pathology and exaggerates the parkinsonian symptoms as well as pathologies in animal model of PD30,31,34can causeParkinson ’s disease ( PD)-like pathology and exaggerates the parkinsonian symptoms as well as pathologies in animal model of PD30,31,34

to retinal degeneration and azoospermia — Oregon Health & Science University Ying Ming Kuo , Jacque L. Duncan , Shawn Westaway , Haidong Yang , George Nune , Eugene Yujun Xu , Susan Hayflick , Jane Gitschier Pantothenate kinase - associated neurodegeneration ( PKAN , formerly known as Hallervorden - Spatz syndromeleadsto retinal degeneration and azoospermia — Oregon Health & Science University Ying Ming Kuo , Jacque L. Duncan , Shawn Westaway , Haidong Yang , George Nune , Eugene Yujun Xu , Susan Hayflick , Jane Gitschier Pantothenate kinase - associated neurodegeneration ( PKAN , formerly known as Hallervorden - Spatz syndrome

striatal dopamine(passive) caused bystriatal dopamine

to an enhanced expression of hepatic TIMP-1ledto an enhanced expression of hepatic TIMP-1

neuroinflammation(passive) caused byneuroinflammation

treatment of endocarditis , pyelonephritis and systemic infections(passive) caused bytreatment of endocarditis , pyelonephritis and systemic infections

I inhibition and dopaminergic deficits(passive) caused byI inhibition and dopaminergic deficits

pulmonary fibrosiscausespulmonary fibrosis

the itching(passive) caused bythe itching

brain damage(passive) caused bybrain damage

arterial stiffening(passive) caused byarterial stiffening

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