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Smart Reasoning:

C&E

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Qaagi - Book of Why

Causes

Effects

the resistance to antiestrogen therapyresultsfrom a cellular adaptation process

their interactionsleadto cellular function and adaptation

signalingleadingto chronic cellular adaptation

the Nrf2 pathway via redox signaling , ... , induction of protective proteins , and improvement of the mitochondrial redox stateleadingto chronic cellular adaptation

Sodium bicarbonatecan influencecellular adaptation processes

an evolutionary cell signalingcontributesto cell adaptation

Several molecular pathwayscausingcell adaptation

an epigenetic responsemay resultin cell adaptation

signalingcontributesto cell adaptation

thingsdo ... causecellular - adaption / degeneration

38leadingto cell adaptation

perturbationsleadingto cellular adaptation to heme

telomere length or DNA damage(passive) caused bycellular senescence

The shortening of telomerecan causecellular senescence

the hypothesis ... telomere shorteningcausescellular senescence

elevated oxidative stress(passive) caused bycellular senescence

DNA damagecan causecellular senescence

oxidative stress(passive) caused bycellular senescence

telomere shortening alone(passive) to be caused bycellular senescence

The phenomenon of contact inhibition ... also appearsto influencecellular senescence

intrinsic aging(passive) is ... caused bycellular senescence

These contrary results ... different stressescausedcellular senescence

dynamic evolutionary changesleadingto cellular adaptation

Aurora A overexpression(passive) caused bycellular senescence

proliferationcausescellular senescence

The breast cancer drug palbociclib arrests cells in G1 phase by CDK4/6 inhibition , but alsocausescellular senescence

These stimuli trigger signal transduction pathways in plantsleadingto cellular adaptation

a variety of factors related to DNA damage , genotoxic stress , and other not - yet - understood factors(passive) is caused byCellular senescence

a series of stepscausescellular senescence

Autophagycan resultin cellular adaptation

Autophagycan resultin cellular adaptation

ParametersInfluencingNeuronal Adaptation

miR-23a-3pcausescellular senescence

Loss of Gm14230 impairs cell growth andcausescellular senescence

clear and easy identification of top processesinfluencingcellular senescence

an essential factorcausingcellular plasticity

a metabolic cascaderesultingin cellular adaptations

Hypoxic stressleadsto cellular adaptations

by hypoxia(passive) influenced bycellular adaptations

Mitochondrial regulatorscontributeto mitotic adaptation

to alcohol toleranceleadingto alcohol tolerance

to cell survival or cell deathleadingto cell survival or cell death

alsocould ... leadalso

to the both type and functionleadsto the both type and function

to daily lifeleadsto daily life

to less frequent reviews and time spent to reach the goalleadingto less frequent reviews and time spent to reach the goal

to systemic changeleadto systemic change

to cancerwill leadto cancer

to cancercan leadto cancer

cancercausingcancer

to increased workloadleadsto increased workload

weight gaininfluenceweight gain

to most cancerscan leadto most cancers

to cancerscan leadto cancers

in cancerscan resultin cancers

in the uncontrolled development and division of cellsresultin the uncontrolled development and division of cells

to a decrease in apoptosiscould leadto a decrease in apoptosis

the uncontrolled expansion and division of cellscausethe uncontrolled expansion and division of cells

from frequent and reversible chromosomal amplificationsresultsfrom frequent and reversible chromosomal amplifications

to the uncontrolled advancement and division of cellsleadto the uncontrolled advancement and division of cells

in reduced drug uptakeresultin reduced drug uptake

to improvedleadto improved

to more general tissue - specific adaptations to hypoxialeadsto more general tissue - specific adaptations to hypoxia

to resistanceleadingto resistance

in reduced sensitivityresultsin reduced sensitivity

in long term behavioral dysfunctionmay resultin long term behavioral dysfunction

to drug resistanceleadingto drug resistance

to the progression of agingdirectly contributesto the progression of aging

to the development of a steroid - independent tumourleadingto the development of a steroid - independent tumour

to the aging of the whole organismcontributesto the aging of the whole organism

to ageing and the development and progression of diseasesleadsto ageing and the development and progression of diseases

to HIV-1 latencycontributeto HIV-1 latency

to HIV-1 latencycontributeto HIV-1 latency

to calorie restriction - induced preservation of skeletal musclecontributesto calorie restriction - induced preservation of skeletal muscle

to neurodegeneration leadsto neurodegeneration

to the regenerative capacity of plantscontributesto the regenerative capacity of plants

to a shift in the phenotype of the tumour cell from steroid dependence to steroid independence / growth factor dependenceleadingto a shift in the phenotype of the tumour cell from steroid dependence to steroid independence / growth factor dependence

to the relatively rapid restoration of aSox2-expressing cell populationleadsto the relatively rapid restoration of aSox2-expressing cell population

to neurodegeneration Sourceleadsto neurodegeneration Source

in eukaryotesresultedin eukaryotes

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Smart Reasoning:

C&E

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