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Qaagi - Book of Why

Causes

Effects

to add L - carnitine to infant formulato preventcarnitine deficiency

This leaflet ... metabolic disorderscausecarnitine deficiency

to reduce GA - producing substrates and carnitine supplementationto preventcarnitine deficiency

he also gets carnitorto preventcarnitine deficiency

a genetic defect in carnitine transport(passive) caused byCarnitine deficiency

The lack of even one of these substancescan causecarnitine deficiency

some medications(passive) can be caused byCarnitine deficiency

• Valproic acid ( Depakotemay causecarnitine deficiency

approximately 100 to 150 metabolic disorderscan causecarnitine deficiency

mutations in the SLC22A5 ( 5q31 ) gene encoding the sodium ion - dependent carnitine transporter ( OCTN2(passive) is caused byCarnitine deficiency

A large amountcan triggercarnitine deficiency

Carnitine deficiency or conditionscausingcarnitine deficiency

kidney disease and dialysis(passive) is caused bycarnitine deficiency

chronic valproate administration more so than acute(passive) to be caused byCarnitine deficiency

valproatescausingcarnitine deficiency

Tandem mass spectrometrydiscoveredcarnitine deficiency

downregulation of the carnitine acyltransferase genes(passive) caused bycarnitine deficiency

A medication used to treat seizures ... well knownto causecarnitine deficiency

The fate of supplemental carnitine ... knownto causecarnitine deficiency

the individual ... a risk allelemay causecarnitine deficiency

Recently , several drugs ( some of antibiotics , anticonvulsants , antineoplastics ) have been reportedto causecarnitine deficiency

short - term treatment of cefteram - pivoxil ( CFTM - PI ) which is one of pivaloyloxymethyl - esterified antibiotics in adult volunteers and diseased children(passive) caused bycarnitine deficiency

valproic acid ( VPAcausescarnitine deficiency

an abnormal accumulation of acidic wastes in the blood ( organic acidemiamay causean abnormal accumulation of acidic wastes in the blood ( organic acidemia

clinical myopathy or cardiomyopathycan causeclinical myopathy or cardiomyopathy

to decreased energy production and an increased risk of heart disease and anginaleadsto decreased energy production and an increased risk of heart disease and angina

cardiomyopathy , skeletal myopathy , hypoketotic coma , hypoglycemia , and hyperammonemiamay causecardiomyopathy , skeletal myopathy , hypoketotic coma , hypoglycemia , and hyperammonemia

muscle necrosis , myoglobinuria , lipid - storage myopathy , hypoglycemia , fatty liver , and Hyperammonemia with muscle aches , fatigue , confusion , and cardiomyopathymay causemuscle necrosis , myoglobinuria , lipid - storage myopathy , hypoglycemia , fatty liver , and Hyperammonemia with muscle aches , fatigue , confusion , and cardiomyopathy

liver failure , high ammonia , cerebral edema , cardiac arrhythmias , cardiomyopathy , and muscle weakness with rhabdomyolysisalso causesliver failure , high ammonia , cerebral edema , cardiac arrhythmias , cardiomyopathy , and muscle weakness with rhabdomyolysis

to muscle weakness , cardiomyopathy , hypoglycemia and liver dysfunction , conditions that are typical of mitochondrial diseases ( http://en.wikipedia.org/wiki/Mitochondrial_diseaseleadsto muscle weakness , cardiomyopathy , hypoglycemia and liver dysfunction , conditions that are typical of mitochondrial diseases ( http://en.wikipedia.org/wiki/Mitochondrial_disease

to accumulation of fatleadsto accumulation of fat

the body to be unable to use long - chain fatty acids as energycausesthe body to be unable to use long - chain fatty acids as energy

if any of those nutrients are at inadequate levelswill resultif any of those nutrients are at inadequate levels

many different problems , including heart failure , muscle weakness or muscle loss , anaemias and lack of energycausesmany different problems , including heart failure , muscle weakness or muscle loss , anaemias and lack of energy

non ketotic hypoglycemia dcan causenon ketotic hypoglycemia d

to cardiovascular disease ( CVDmay contributeto cardiovascular disease ( CVD

an impairment of other fatty acids oxidation leading to the obesity and lipids disorders that some VPA - treated patients experience [ 23could also causean impairment of other fatty acids oxidation leading to the obesity and lipids disorders that some VPA - treated patients experience [ 23

adenosine triphosphate synthesis(passive) caused byadenosine triphosphate synthesis

the metabolization of fats for energypreventsthe metabolization of fats for energy

the fatty acids to back up and accumulate in the blood ultimately resulting in additional deposition of fat , usually right in the areas where you already have the greatest accumulationcausesthe fatty acids to back up and accumulate in the blood ultimately resulting in additional deposition of fat , usually right in the areas where you already have the greatest accumulation

Hyperammonemic encephalopathy(passive) caused byHyperammonemic encephalopathy

to heart and hepatic disease , myopathy , nonketotic hypoglycemia , and neurological complications.[1leadsto heart and hepatic disease , myopathy , nonketotic hypoglycemia , and neurological complications.[1

alsocan ... resultalso

after my daughter was bornwas discoveredafter my daughter was born

the paincausingthe pain

from developing in all dialysis patients by addition of L - carnitine hemodialysis and peritoneal dialysis solutions in low subtherapeutic concentrations that are equal to or below the concentration of free carnitine normal serumpreventedfrom developing in all dialysis patients by addition of L - carnitine hemodialysis and peritoneal dialysis solutions in low subtherapeutic concentrations that are equal to or below the concentration of free carnitine normal serum

in accumulation of non - oxidized fatty acyl - coenzyme A moleculesresultsin accumulation of non - oxidized fatty acyl - coenzyme A molecules

cardiac hypertrophy(passive) caused bycardiac hypertrophy

cisplatin - induced hepatotoxicityprovokescisplatin - induced hepatotoxicity

in low energy levelstypically resultingin low energy levels

a much larger fraction than now assumedmight causea much larger fraction than now assumed

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