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Qaagi - Book of Why

Causes

Effects

If they were performing at a high level , they would use oxygen to break lactate down to carbon dioxide and waterpreventinglactate from pouring into the blood

metabolizing glucose / sugar(passive) caused bylactate load

the position of the entire lungresultsin the pleural fluid lactate dehydrogenase ( LDH

as pharmacological MCT blockage failedto preventlactate depletion

exogenous lactate stimulationmay preventMCT1-mediated excretion of lactate

ambient temperature , limp position , site , age of the patient , and room lighting(passive) is influenced bycapillary refill time

4108causesCapillary refill time

Factorsinfluencingcapillary refill time

ambient temperature,25 site , and(passive) is influenced byCapillary refill time

to a poor skin perfusion and prolonged capillary refill time ( > 2 secondsleadsto a poor skin perfusion and prolonged capillary refill time ( > 2 seconds

in these raised lactate blood levels and increases a patient ’s risk of developing lactic acidosisresultsin these raised lactate blood levels and increases a patient ’s risk of developing lactic acidosis

a reduction in depolarization - induced response ... with response recovering on reapplication of lactatecauseda reduction in depolarization - induced response ... with response recovering on reapplication of lactate

cardiovascular collapse , which could be reversed by infusing sodium lactate ( Levy 2007causedcardiovascular collapse , which could be reversed by infusing sodium lactate ( Levy 2007

in the accumulation of lactate outpaces in the bloodresultingin the accumulation of lactate outpaces in the blood

muscle fatiguecausesmuscle fatigue

from burning a lot of glucosecreatedfrom burning a lot of glucose

to a rapid efflux of protons from the cell that diminished slowly over timeledto a rapid efflux of protons from the cell that diminished slowly over time

Septic Shock and Severe Sepsis Blood cultures Blood culture draw before antibiotics Septic Shock and Severe Sepsis Antibiotics Antibiotics received Septic Shock and Severe Sepsis 30 cc / kg IV fluidsresultedSeptic Shock and Severe Sepsis Blood cultures Blood culture draw before antibiotics Septic Shock and Severe Sepsis Antibiotics Antibiotics received Septic Shock and Severe Sepsis 30 cc / kg IV fluids

from burning lots of glucose / sugarcreatedfrom burning lots of glucose / sugar

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Smart Reasoning:

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