The claimed work ... two doctorsdiscoveredpaternal cell - free fetal DNA ( cffDNA ... in maternal blood serum and plasma
Inc. In 1996 , inventors Dennis Lo and James Wainscoatdiscoveredthat maternal plasma and serum contained cell - free fetal DNA ( “ cffDNA
the chromosomecontributes1.35 % of the total maternal and fetal DNA in the mother's blood
male fetuses compared with female fetuses(passive) contributed bychrX and chrY DNA sequences in maternal plasma
a genetic defect in the dystrophia myotonica - protein kinase ( DMPK ) gene in which a sequence of three nucleotides repeats extensively , creating an abnormally long toxic RNA , which accumulates in the cell and prevents the production of proteins needed for normal cellular function(passive) is caused byFetal DNA in maternal plasma : biology and diagnostic applicationsIt
This wayward patent tale ... two doctorsdiscoveredcell - free fetal DNA ( cffDNA ) circulating in maternal plasma
Lo and Wainscoatdiscoveredthat cell - free fetal DNA ( cffDNA ) in maternal plasma and serum
Prof. Lo Yuk - ming Dennisdiscoveredthe presence of fetal DNA in the maternal blood plasma ... and pioneered the use of such markers for fetal DNA diagnosis
to the introduction of noninvasive prenatal tests with high sensitivity and high specificity for common aneuploidies ( trisomy 13 , trisomy 18 , trisomy 21has ledto the introduction of noninvasive prenatal tests with high sensitivity and high specificity for common aneuploidies ( trisomy 13 , trisomy 18 , trisomy 21
preterm deliveries in the general populationto preventpreterm deliveries in the general population
to anon - invasive prenatal test for Downs ' Syndromecan leadto anon - invasive prenatal test for Downs ' Syndrome
in 1997discoveredin 1997
for the development of preeclampsiamay causefor the development of preeclampsia
maternal sensitization to Rh blood groupsmay causematernal sensitization to Rh blood groups