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QSAR methods ... valuableto designbetter H3R antagonists / inverse agonists
Alcohol ... a central nervous system ( CNS ) depressantinfluencesneurotransmitters like GABA
Blocks alpha adrenergic receptorscausingvasodilation Cholinergic agonist
PD tolerance of ethanol and concernCausesdown - regulation of GABA receptors
BDNFmay causeneurotoxicity from GABA - A agonists
the formation of amyloid protein and acetylcholinesterase activitycan causelysis of acetylcholine ( neurotransmitter
The ability of cannabidiol to behave asmay contributea CB2 receptor inverse agonist
of two major functional domains : an agonist - binding site and an ionophore or channel domain(passive) is composedNicotinic acetylcholine receptor
of two alpha(passive) are composedGABA - A receptors
the breakdown product of progesterone , called allopregnanoloneinfluencesGABA receptors
which results in a more restful mind(passive) are influencedGABA receptors
Kavalactonesmay influenceGABA receptors
Ferring with strong potential in gastrointestinal and oncology indications(passive) discovered bypeptide-2 receptor ( GLP-2 ) agonist
Phenibut(passive) caused byGABA receptors
opioiddiscoveredreceptor agonist
in a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline in the 1990s(passive) was inventedreceptor agonist
yet unidentified compounds beyond apigeninmay influenceGABA receptors
the inhibitory effectsresultingfrom a GABA agonist
GABA release from specialized interneurons(passive) caused byspillover of GABA
already(passive) have ... been ... discoveredinverse agonists
The ETB receptordid ... causeagonist
by activation of PPAR(passive) is ... caused byagonist
by John W. Huffman at Clemson University(passive) discovered byagonist
transporterdesignedagonist
memory disruption(passive) caused bymemory disruption
memory disruptions(passive) caused bymemory disruptions
to " food intake reduction and weight lossledto " food intake reduction and weight loss
in a decrease of basal activityresultingin a decrease of basal activity
significant changes in energy balanceto causesignificant changes in energy balance
to positive metabolic and cardiovascular effectsledto positive metabolic and cardiovascular effects
in increased effect of GABAresultsin increased effect of GABA
in increased effect of GABAresultingin increased effect of GABA
receptors to respond in ways opposite their response to agonists such as THC and anandamideto causereceptors to respond in ways opposite their response to agonists such as THC and anandamide
in an increased response to endogenous GABAresultingin an increased response to endogenous GABA
in an enhancement of the binding of GABA to the GABAA receptor which results in inhibitory effects on the central nervousresultingin an enhancement of the binding of GABA to the GABAA receptor which results in inhibitory effects on the central nervous
a dysfunction in the cholinergic neuronal system in micecausesa dysfunction in the cholinergic neuronal system in mice
a dysfunction in the cholinergic neuronal systemcausesa dysfunction in the cholinergic neuronal system
an enhancement of GABA on the drugcausesan enhancement of GABA on the drug
a wide range of ancillary effects not directly related to sleep ... depending on the precise subset of gamma aminobutyric acid receptors activatedcan causea wide range of ancillary effects not directly related to sleep ... depending on the precise subset of gamma aminobutyric acid receptors activated
a dysfunction in the cholinergic neuronalcausesa dysfunction in the cholinergic neuronal
to the activation of GABAergic systemsleadsto the activation of GABAergic systems
on the excitement of the neurons in the central nervous systeminfluenceon the excitement of the neurons in the central nervous system
in the processes which reduce the agitation of the central nervous systemresultingin the processes which reduce the agitation of the central nervous system
in the processes which reduce the agitation of the centralresultingin the processes which reduce the agitation of the central
to eliminate blood - brain barrier penetration and subsequent brain CB1 receptor occupancy that mediates the neuropsychiatric adverse events associated with first - generation CB1 inverse agonistsdesignedto eliminate blood - brain barrier penetration and subsequent brain CB1 receptor occupancy that mediates the neuropsychiatric adverse events associated with first - generation CB1 inverse agonists
in a legal manner and dose , and strengthresultingin a legal manner and dose , and strength
to eliminate blood - brain barrier penetration and brain CB1 receptor occupancy that mediate the neuropsychiatric issues associated with first - generation CB1 inverse agonistsspecifically designedto eliminate blood - brain barrier penetration and brain CB1 receptor occupancy that mediate the neuropsychiatric issues associated with first - generation CB1 inverse agonists
anxietyalso causeanxiety
used as andesignedused as an
to eliminate blood - brain barrier penetration and subsequent brain CB1 receptor occupancy that mediates the neuropsychiatric adverse events associated with first - generation CB1 inverse agonistsdesignedto eliminate blood - brain barrier penetration and subsequent brain CB1 receptor occupancy that mediates the neuropsychiatric adverse events associated with first - generation CB1 inverse agonists
to recruitment of corepressor and suppression of basal transcription of LXRleadingto recruitment of corepressor and suppression of basal transcription of LXR
to eliminate blood - brain barrier penetration and brain CB1 receptor occupancy that mediate the neuropsychiatric issues associated with first - generation CB1 inverse agonistsspecifically designedto eliminate blood - brain barrier penetration and brain CB1 receptor occupancy that mediate the neuropsychiatric issues associated with first - generation CB1 inverse agonists
to enhanced surface localizationleadsto enhanced surface localization
in decreased activityresultin decreased activity
an opposite action to that of agonistscausean opposite action to that of agonists
an agonist responsecausesan agonist response
an action opposite to that of the agonistcausean action opposite to that of the agonist
an action opposite to that of the agonistcausesan action opposite to that of the agonist
an action opposite to that from the agonistwill causean action opposite to that from the agonist
an motion opposite to that in the agonistwill causean motion opposite to that in the agonist
an actioncausesan action
an actioncausesan action
to significant suppression of IL-17 under the same assay conditionsledto significant suppression of IL-17 under the same assay conditions
to their anxiogenic and convulsant effectslikely contributingto their anxiogenic and convulsant effects